Gene and Cell Therapy for Epilepsy: A Mini Review

Mesenchymal Stem Cell-Based Therapy for Lysosomal Storage Diseases and Other Neurodegenerative Disorders

(2022) Shaza S. Issa et al.   Frontiers in Pharmacology

Clinical benefits of single vs repeated courses of mesenchymal stem cell therapy in epilepsy patients

(2021) Fedor Hlebokazov et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

(2020) Gaia Colasante et al.   BRAIN

Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy

(2020) Elzbieta Szczepanik et al.   Stem Cells International

The Genetics of Epilepsy

(2020) Piero Perucca et al.   Annual Review of Genomics and Human Genetics

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

(2020) Giuseppe Ronzitti et al.   Frontiers in Immunology

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

(2020) Dae Hyun Ha et al.   Cells

Biology and therapeutic potential of mesenchymal stem cell‐derived exosomes

(2020) Zhou Xunian et al.   CANCER SCIENCE

Adipose-Derived Stem Cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy

(2020) Lili Wang et al.   BRAIN RESEARCH

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

(2020) Reut Guy et al.   Biomolecules

Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

(2020) Julia Alicja Szczygieł et al.   Frontiers in Molecular Neuroscience

Long-term, targeted delivery of GDNF from encapsulated cells is neuroprotective and reduces seizures in the pilocarpine model of epilepsy

(2019) Giovanna Paolone et al.   JOURNAL OF NEUROSCIENCE

Hippocampal GAD67 transduction using rAAV8 regulates epileptogenesis in EL mice

(2019) Kuniko Shimazaki et al.   Molecular Therapy-Methods & Clinical Development

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress

(2019) Pedro Antônio Schmidt do Prado-Lima et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Designer receptor technology for the treatment of epilepsy

(2019) Andreas Lieb et al.   EBioMedicine

The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases

(2019) Armita Mahdavi Gorabi et al.   MOLECULAR NEUROBIOLOGY

Disease modification by combinatorial single vector gene therapy: a preclinical translational study in epilepsy

(2019) Esbjörn Melin et al.   Molecular Therapy-Methods & Clinical Development

Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models

(2019) Yana Mukhamedshina et al.   Biomolecules

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus

(2018) Shinobu Fukumura et al.   EPILEPSY RESEARCH

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

(2018) Kim L. Powell et al.   NEUROBIOLOGY OF DISEASE

New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy

(2018) Neveen A. Salem et al.   INFLAMMOPHARMACOLOGY

Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy

(2018) Chiara Falcicchia et al.   Molecular Therapy-Methods & Clinical Development

Neurochemical properties of neurospheres infusion in experimental-induced seizures

(2018) Mirna Luciano de Gois da Silva et al.   TISSUE & CELL

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

(2018) Dinesh Upadhya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adeno-associated viral vector-mediated preprosomatostatin expression suppresses induced seizures in kindled rats

(2017) Gowri Natarajan et al.   EPILEPSY RESEARCH

Nonintegrating Gene Therapy Vectors

(2017) Takis Athanasopoulos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

(2017) Francisco Vizoso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells

(2017) Jaderson C. DaCosta et al.   Journal of Tissue Engineering and Regenerative Medicine

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

(2017) Qianfa Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Autologous Bone Marrow-Derived CD271+ Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children

(2017) Olga Milczarek et al.   Stem Cells Translational Medicine

Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors

(2016) Litsa Nikitidou Ledri et al.   NEUROBIOLOGY OF DISEASE

Preserved Hippocampal Glucose Metabolism on18F-FDG PET after Transplantation of Human Umbilical Cord Blood-derived Mesenchymal Stem Cells in Chronic Epileptic Rats

(2015) Ga Young Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice

(2014) Miles Cunningham et al.   Cell Stem Cell

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

(2014) D Young et al.   GENE THERAPY

Effects of Intravenous Human Umbilical Cord Blood Mesenchymal Stem Cell Therapy versus Gabapentin in Pentylenetetrazole-Induced Chronic Epilepsy in Rats

(2014) Amira S. Mohammed et al.   PHARMACOLOGY

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus

(2013) Litsa Nikitidou et al.   EPILEPSIA

Early Transplantation of Bone Marrow Mononuclear Cells Promotes Neuroprotection and Modulation of Inflammation After Status Epilepticus in Mice by Paracrine Mechanisms

(2013) Marcos Maurício Tosta Leal et al.   NEUROCHEMICAL RESEARCH

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Current prospects and challenges for epilepsy gene therapy

(2011) Marc S. Weinberg et al.   EXPERIMENTAL NEUROLOGY

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

(2011) Casper R. Gøtzsche et al.   NEUROBIOLOGY OF DISEASE

Improvement of the pilocarpine epilepsy model in rat using bone marrow stromal cell therapy

(2011) Alireza Abdanipour et al.   NEUROLOGICAL RESEARCH

BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats

(2010) Satoshi Kuramoto et al.   BRAIN RESEARCH

Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy

(2010) Zaquer S.M. Costa-Ferro et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Medial Ganglionic Eminence-Derived Neural Stem Cell Grafts Ease Spontaneous Seizures and Restore GDNF Expression in a Rat Model of Chronic Temporal Lobe Epilepsy

(2010) Ben Waldau et al.   STEM CELLS

Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression

(2009) Katrin Montzka et al.   BMC NEUROSCIENCE

GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus

(2009) Irene Kanter-Schlifke et al.   EXPERIMENTAL NEUROLOGY

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice

(2009) S. C. Baraban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

(2008) Francesco Noè et al.   BRAIN

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

(2008) Andreas T. Sørensen et al.   HIPPOCAMPUS