Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons

The GABA Polarity Shift and Bumetanide Treatment: Making Sense Requires Unbiased and Undogmatic Analysis

(2022) Yehezkel Ben-Ari et al.   Cells

The Multifaceted Roles of KCC2 in Cortical Development

(2021) Mari A. Virtanen et al.   TRENDS IN NEUROSCIENCES

Impaired KCC2 Function Triggers Interictal-Like Activity Driven by Parvalbumin-Expressing Interneurons in the Isolated Subiculum In Vitro

(2021) Max Anstötz et al.   CEREBRAL CORTEX

The postnatal GABA shift: A developmental perspective

(2021) Carlijn Peerboom et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Development, Diversity, and Death of MGE-Derived Cortical Interneurons

(2021) Rhîannan H. Williams et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons

(2021) Sana Al Awabdh et al.   JOURNAL OF NEUROSCIENCE

When Are Depolarizing GABAergic Responses Excitatory?

(2021) Werner Kilb   Frontiers in Molecular Neuroscience

Loss of non‐canonical KCC 2 functions promotes developmental apoptosis of cortical projection neurons

(2020) Martina Mavrovic et al.   EMBO REPORTS

GABAergic interneurons in epilepsy: More than a simple change in inhibition

(2020) Joseane Righes Marafiga et al.   EPILEPSY & BEHAVIOR

BDNF Expression in Cortical GABAergic Interneurons

(2020) Federico José Barreda Tomás et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cation–chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons

(2020) Yo Otsu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chloride homeodynamics underlying modal shifts in cellular and network oscillations

(2020) Atsuo Fukuda   NEUROSCIENCE RESEARCH

Intracellular Cl− dysregulation causing and caused by pathogenic neuronal activity

(2020) Tenpei Akita et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Parvalbumin interneuron vulnerability and brain disorders

(2020) Jacob B. Ruden et al.   NEUROPSYCHOPHARMACOLOGY

GABAergic interneurons excite neonatal hippocampus in vivo

(2020) Yasunobu Murata et al.   Science Advances

The Parvalbumin Hypothesis of Autism Spectrum Disorder

(2020) Federica Filice et al.   Frontiers in Cellular Neuroscience

KCC2 chloride transport contributes to the termination of ictal epileptiform activity

(2020) Volodymyr I. Dzhala et al.   eNeuro

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

(2019) Marie Goutierre et al.   Cell Reports

GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex

(2019) Zhe Ran S. Duan et al.   NEURON

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

(2019) Miho Watanabe et al.   Science Signaling

Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling

(2018) Megan L. Brady et al.   NEUROPHARMACOLOGY

Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions

(2018) Joran T. Schulte et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

KCC2, epileptiform synchronization, and epileptic disorders

(2018) Graziella Di Cristo et al.   PROGRESS IN NEUROBIOLOGY

An Emerging Circuit Pharmacology of GABA A Receptors

(2018) Elif Engin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development and Functional Diversification of Cortical Interneurons

(2018) Lynette Lim et al.   NEURON

Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction

(2018) Atsuo Fukuda et al.   BRAIN RESEARCH

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA B Receptor Protein Complex

(2017) Rebecca Wright et al.   JOURNAL OF NEUROSCIENCE

Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential

(2017) Joseph Glykys et al.   TRENDS IN NEUROSCIENCES

Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits

(2017) Marilena Griguoli et al.   Frontiers in Cellular Neuroscience

Hyperpolarization-independent maturation and refinement of GABA/glycinergic connections in the auditory brain stem

(2016) Hanmi Lee et al.   JOURNAL OF NEUROPHYSIOLOGY

An Optogenetic Approach for Investigation of Excitatory and Inhibitory Network GABA Actions in Mice Expressing Channelrhodopsin-2 in GABAergic Neurons

(2016) Guzel Valeeva et al.   JOURNAL OF NEUROSCIENCE

Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits

(2016) Sebnem N. Tuncdemir et al.   NEURON

Postnatal development of GABAergic interneurons in the neocortical subplate of mice

(2016) G.-J. Qu et al.   NEUROSCIENCE

De novo synaptogenesis induced by GABA in the developing mouse cortex

(2016) Won Chan Oh et al.   SCIENCE

Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

(2016) Hirotomo Saitsu et al.   Scientific Reports

Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons

(2016) Sabrina Zechel et al.   eLife

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX

(2015) Olaya Llano et al.   JOURNAL OF CELL BIOLOGY

KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation

(2015) Q. Chevy et al.   JOURNAL OF NEUROSCIENCE

KCC2 activity is critical in limiting the onset and severity of status epilepticus

(2015) Liliya Silayeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of cortical neuronal migration by glutamate and GABA

(2015) Heiko J. Luhmann et al.   Frontiers in Cellular Neuroscience

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

(2015) Nancy D. Merner et al.   Frontiers in Cellular Neuroscience

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

(2015) Knut Kirmse et al.   Nature Communications

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

(2014) K. T. Kahle et al.   EMBO REPORTS

Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells

(2014) Mamoru Fukuchi et al.   JOURNAL OF NEUROCHEMISTRY

Novel determinants of the neuronal Cl−concentration

(2014) Eric Delpire et al.   JOURNAL OF PHYSIOLOGY-LONDON

GABA receptors in brain development, function, and injury

(2014) Connie Wu et al.   METABOLIC BRAIN DISEASE

Interneuron cell types are fit to function

(2014) Adam Kepecs et al.   NATURE

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex

(2014) Jeremy Biane et al.   Frontiers in Cellular Neuroscience

A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations

(2014) Naoki Takada et al.   Nature Communications

Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons

(2014) Vivek Mahadevan et al.   Cell Reports

Parvalbumin tunes spike-timing and efferent short-term plasticity in striatal fast spiking interneurons

(2013) David Orduz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neto2 is a KCC2 interacting protein required for neuronal Cl−regulation in hippocampal neurons

(2013) Evgueni A. Ivakine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of glycemic control on seizures and seizure-induced excitotoxic cell death

(2012) Paula Schauwecker   BMC NEUROSCIENCE

Timing of developmental sequences in different brain structures: physiological and pathological implications

(2012) N. Dehorter et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development

(2012) S. Z. Young et al.   JOURNAL OF NEUROSCIENCE

Intrinsic and Extrinsic Mechanisms Control the Termination of Cortical Interneuron Migration

(2012) N. Inamura et al.   JOURNAL OF NEUROSCIENCE

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Epilepsy as a Neurodevelopmental Disorder

(2012) Yuri Bozzi et al.   Frontiers in Psychiatry

GABA Regulates the Multidirectional Tangential Migration of GABAergic Interneurons in Living Neonatal Mice

(2011) Hiroyuki Inada et al.   PLoS One

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders

(2011) E. Rossignol   NEURAL PLASTICITY

Neurotransmitter signaling in postnatal neurogenesis: The first leg

(2010) Jean-Claude Platel et al.   BRAIN RESEARCH REVIEWS

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

(2010) Zachi Horn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex

(2010) Chitoshi Takayama et al.   NEUROSCIENCE RESEARCH

Desynchronization of Neocortical Networks by Asynchronous Release of GABA at Autaptic and Synaptic Contacts from Fast-Spiking Interneurons

(2010) Frédéric Manseau et al.   PLOS BIOLOGY

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner

(2009) Dante Bortone et al.   NEURON

Developmental profile of GABAA-mediated synaptic transmission in pyramidal cells of the somatosensory cortex

(2008) Masayuki Kobayashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Excitatory GABA in Rodent Developing Neocortex In Vitro

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex

(2008) C. Allene et al.   JOURNAL OF NEUROSCIENCE

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Fate mapping Nkx2.1-lineage cells in the mouse telencephalon

(2007) Qing Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY