FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 7, Pages 3005-3015
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2016-12-23
DOI
10.1074/jbc.m116.769455
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?
- (2016) Evan E. Santo et al. CELL CYCLE
- Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells
- (2016) Raymond Liang et al. CELL CYCLE
- FoxO3 suppresses Myc-driven lymphomagenesis
- (2016) C J Vandenberg et al. Cell Death & Disease
- Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
- (2015) P. Rimmele et al. EMBO REPORTS
- The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression
- (2015) Arnav Mehta et al. IMMUNITY
- Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress
- (2015) Anna Campalans et al. MOLECULAR AND CELLULAR BIOLOGY
- Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
- (2015) Dagmar Walter et al. NATURE
- Partial loss of the DNA repair scaffolding protein, Xrcc1 , results in increased brain damage and reduced recovery from ischemic stroke in mice
- (2015) Somnath Ghosh et al. NEUROBIOLOGY OF AGING
- JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation
- (2015) J S Ahn et al. ONCOGENE
- A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis
- (2015) Raymond Liang et al. PLoS Genetics
- FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis
- (2014) Xin Zhang et al. AMERICAN JOURNAL OF HEMATOLOGY
- Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle
- (2014) Isabel Beerman et al. Cell Stem Cell
- Stem cells and the impact of ROS signaling
- (2014) C. L. Bigarella et al. DEVELOPMENT
- Fancd2 Is Required for Nuclear Retention of Foxo3a in Hematopoietic Stem Cell Maintenance
- (2014) Xiaoli Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier
- (2014) Margarida A. Santos et al. NATURE
- The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
- (2014) Francesca Pellicano et al. STEM CELLS
- HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β
- (2014) Qingming Fang et al. Nature Communications
- Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
- (2014) Pauline Rimmelé et al. Stem Cell Reports
- Stem Cells, Redox Signaling, and Stem Cell Aging
- (2013) Raymond Liang et al. ANTIOXIDANTS & REDOX SIGNALING
- BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
- (2013) Eleni D. Lagadinou et al. Cell Stem Cell
- A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression
- (2013) C Marty et al. LEUKEMIA
- FOXO3 Selectively Amplifies Enhancer Activity to Establish Target Gene Regulation
- (2013) Astrid Eijkelenboom et al. Cell Reports
- Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons
- (2012) David Svilar et al. Jove-Journal of Visualized Experiments
- Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
- (2011) T. Yahata et al. BLOOD
- AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
- (2011) Stephen M. Sykes et al. CELL
- Regulation and Function of FoxO Transcription Factors in Normal and Cancer Stem Cells: What Have We Learned?
- (2011) Xin Zhang et al. CURRENT DRUG TARGETS
- 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes
- (2011) Justyna Janik et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
- (2011) Xin Zhang et al. NATURE CELL BIOLOGY
- Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage
- (2010) David Svilar et al. ANTIOXIDANTS & REDOX SIGNALING
- I B kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia
- (2010) N. Chapuis et al. BLOOD
- mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
- (2010) Jae Y. Lee et al. Cell Stem Cell
- Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
- (2010) Mary Mohrin et al. Cell Stem Cell
- ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice
- (2010) Safak Yalcin et al. EMBO JOURNAL
- The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response
- (2010) Arjan B. Brenkman et al. FASEB JOURNAL
- TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
- (2010) Kazuhito Naka et al. NATURE
- Oxidative stress-specific interaction between FANCD2 and FOXO3a
- (2009) J. Li et al. BLOOD
- High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics
- (2009) Carlos M. Santamaría et al. LEUKEMIA RESEARCH
- FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging
- (2008) K. Miyamoto et al. BLOOD
- Stems Cells and the Pathways to Aging and Cancer
- (2008) Derrick J. Rossi et al. CELL
- Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells
- (2008) Safak Yalcin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells
- (2008) Aida Muslimovic et al. Nature Protocols
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started