FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage

FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?

(2016) Evan E. Santo et al.   CELL CYCLE

Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells

(2016) Raymond Liang et al.   CELL CYCLE

FoxO3 suppresses Myc-driven lymphomagenesis

(2016) C J Vandenberg et al.   Cell Death & Disease

Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

(2015) P. Rimmele et al.   EMBO REPORTS

The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

(2015) Arnav Mehta et al.   IMMUNITY

Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress

(2015) Anna Campalans et al.   MOLECULAR AND CELLULAR BIOLOGY

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Partial loss of the DNA repair scaffolding protein, Xrcc1 , results in increased brain damage and reduced recovery from ischemic stroke in mice

(2015) Somnath Ghosh et al.   NEUROBIOLOGY OF AGING

JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation

(2015) J S Ahn et al.   ONCOGENE

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

(2015) Raymond Liang et al.   PLoS Genetics

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis

(2014) Xin Zhang et al.   AMERICAN JOURNAL OF HEMATOLOGY

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

Fancd2 Is Required for Nuclear Retention of Foxo3a in Hematopoietic Stem Cell Maintenance

(2014) Xiaoli Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

(2014) Margarida A. Santos et al.   NATURE

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

(2014) Francesca Pellicano et al.   STEM CELLS

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

(2014) Qingming Fang et al.   Nature Communications

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

Stem Cells, Redox Signaling, and Stem Cell Aging

(2013) Raymond Liang et al.   ANTIOXIDANTS & REDOX SIGNALING

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression

(2013) C Marty et al.   LEUKEMIA

FOXO3 Selectively Amplifies Enhancer Activity to Establish Target Gene Regulation

(2013) Astrid Eijkelenboom et al.   Cell Reports

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons

(2012) David Svilar et al.   Jove-Journal of Visualized Experiments

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

(2011) T. Yahata et al.   BLOOD

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

Regulation and Function of FoxO Transcription Factors in Normal and Cancer Stem Cells: What Have We Learned?

(2011) Xin Zhang et al.   CURRENT DRUG TARGETS

8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes

(2011) Justyna Janik et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

(2011) Xin Zhang et al.   NATURE CELL BIOLOGY

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

(2010) David Svilar et al.   ANTIOXIDANTS & REDOX SIGNALING

I B kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

(2010) N. Chapuis et al.   BLOOD

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response

(2010) Arjan B. Brenkman et al.   FASEB JOURNAL

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Oxidative stress-specific interaction between FANCD2 and FOXO3a

(2009) J. Li et al.   BLOOD

High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics

(2009) Carlos M. Santamaría et al.   LEUKEMIA RESEARCH

FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

(2008) K. Miyamoto et al.   BLOOD

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

(2008) Safak Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells

(2008) Aida Muslimovic et al.   Nature Protocols