Article
Oncology
Shuai Zhang, Xuqiang Liao, Jiawei Chen
Summary: Primary malignant fibrous histiocytoma of the lung (PMFHL) is a rare lung disease with no specific symptoms, commonly located in the right lung, and brain and bone being the common metastatic sites. This study reported a case of PMFHL patient with brain metastasis, who was found to have EML4-ALK gene rearrangement through genetic testing. Treatment with alectinib effectively delayed the progression of the disease, resulting in a satisfactory overall survival time of 19 months.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Dejian Li, Kai Zhao, Ziwen Zhao, Bo Jiang, Xianxu Gong, Yan Zhang, Yingqi Guo, Han Xiao, Ye Wang, Hui Liu, Chengqing Yi, Wenguang Gu
Summary: The study identified dysregulation of miRNAs in MFH, with 16 upregulated and 31 downregulated. Differential miRNAs showed different expression in cell resistant strains compared to the control group. Quantitative polymerase chain reaction confirmed significant variations in seven miRNAs and four target genes. Hsa-miR-206 was found to significantly inhibit MFH proliferative activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Marc P. Vocht, Patricija Tomasic, Ronald Beyer, Alexandra Mueller, Ulrich Zuberbuehler, Bernd Stuermer, Frank Hermanutz, Michael R. Buchmeiser
Summary: Poly(ethyleneimine) (PEI) immobilized on support materials is an effective method for carbon dioxide (CO2) capture from the atmosphere, requiring less energy for thermal desorption. This study introduces fibrous PEI-functionalized carrier systems based on cellulose, cellulose tosylate (CT), and cellulose carbamate (CC). Branched PEI has higher CO2 sorption capacities compared to linear PEIs, and under wet conditions, a PEI-functionalized nonwoven material exhibits a sorption capacity of 0.026 mg CO2/mg adsorbent with complete and reversible CO2 desorption achieved at 80 degrees C.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Food Science & Technology
Xiaoling Li, Meicui Chen, Zhicui Yao, Hongzhen Du, Tianfeng Zhang, Haiyue Wang, Ying Xie, Zengning Li
Summary: Jujuboside B (JUB) induces apoptosis of colorectal cancer cells by promoting ROS generation and inactivating the PI3K/Akt signaling pathway, leading to tumor growth inhibition.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Chunxiao Mou, Yuxi Wang, Shuonan Pan, Kaichuang Shi, Zhenhai Chen
Summary: This research investigated the cell apoptosis induced by Porcine sapelovirus (PSV) infection and its underlying mechanisms. The results showed typical features of apoptosis, such as nuclear condensation and fragmentation, after infection. Cell apoptosis was confirmed by analyzing apoptotic rates, caspase activation, and PARP1 cleavage. The study found that 2A protein encoded by PSV was a crucial factor in inducing the mitochondrial apoptotic pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ning Gao, Ai-Qing Yang, Hui-Rong Xu, Liang Li
Summary: This case report describes a rare synchronous occurrence of breast cancer and axillary sarcoma in a 78-year-old female patient. The patient underwent surgery, endocrine therapy and radiotherapy, and showed no signs of local recurrence or distant metastasis during 1-year follow-up.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Pediatrics
Manuela Dicembrino, Irene Alejandra Barbieri, Carla Pereyra, Vivian Leske
Summary: This study aimed to investigate the use of PetCO(2) and PtcCO(2) as surrogates for PaCO2 in awake children. Results showed that PtcCO(2) had better agreement with PaCO2, but due to wide dispersion of values, neither method can replace the gold standard arterial blood gas analysis.
PEDIATRIC PULMONOLOGY
(2021)
Article
Plant Sciences
Sandeep Kumar, Praveen Kumar Verma, Alok Shukla, Rishi Kant Singh, Anand Kumar Patel, Lokesh Yadav, Sanjay Kumar, Naveen Kumar, Kaushalendra, Arbind Acharya
Summary: This study investigates the anti-cancer effects of Moringa oleifera leaf extract against murine NHL cells in vitro and in vivo. The results suggest that the leaf extract induces apoptosis and inhibits the growth of Dalton's lymphoma.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shu-fen He, Wei-chao Han, Ying-ying Shao, Han-bin Zhang, Wen-xin Hong, Qiu-hong Yang, Yu-qing Zhang, Rui-rong He, Jing Sun
Summary: Three novel cyclometalated iridium(III) compounds were synthesized and evaluated for their anti-cancer properties. Among them, Ir1 showed high cytotoxicity against HeLa cells and triggered apoptosis by reducing mitochondrial membrane potential and depleting ATP levels.
BIOORGANIC CHEMISTRY
(2023)
Article
Cell Biology
Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon
Summary: Malignant pleural mesothelioma is an aggressive cancer linked to asbestos exposure with poor prognosis. Dysregulation of Notch signaling may contribute to cancer progression. Metformin is an effective anti-tumor drug, showing inhibitory effects on MPM cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linyan Lv, Yajie Chang, Yanqing Li, Haicheng Chen, Jiahui Yao, Yun Xie, Xiaoyan Liang, Xing Yang, Min Zhang, Guihua Liu
Summary: Triptolide is widely used in clinical treatment, but its side effects, including reproductive toxicity, lack detailed mechanisms and intervention targets. This study found that triptolide activates the mitochondrial apoptosis pathway in rat testicular Leydig cells, inducing cell apoptosis and potentially causing hypoleydigism. Inhibiting Drp1 over-activation may be a new strategy to mitigate triptolide's reproductive toxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Dairy & Animal Science
Juan Huang, Yanting Zhang, Anchun Cheng, Mingshu Wang, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Zhongqiong Yin, Renyong Jia
Summary: In this study, the function of the DuCV2 ORF3 protein in viral pathogenesis in host cells was investigated. It was found that this protein induces apoptosis through the mitochondrial pathway, and such function is dependent on ORF3 C-20.
Article
Agriculture, Dairy & Animal Science
Juan Huang, Yanting Zhang, Anchun Cheng, Mingshu Wang, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Zhongqiong Yin, Renyong Jia
Summary: Duck circovirus genotype 2 (DuCV2), a member of Circoviridae family, can cause lymphocyte atrophy and necrosis in ducks, leading to immunosuppression. The function of DuCV2 ORF3 protein in viral pathogenesis remains unclear. This study showed that ORF3 protein induced nuclear shrinkage and fragmentation, and promoted caspase-related gene expression, indicating its activation of the mitochondrial apoptosis pathway. Deletion of the 20 amino acids at the C-terminus of ORF3 reduced apoptosis rates and downregulated key molecules in the mitochondrial apoptotic pathway. Overall, the DuCV2 ORF3 protein primarily activates apoptosis through the mitochondrial pathway in DEFs, and this function is ORF3 C20 dependent.
Article
Cell Biology
Dongjie Zhou, Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Jungseok Choi, Kwan-Suk Kim, Xiang-Shun Cui
Summary: In this study, the mRNA level of YME1L1 was knocked down in pig embryos and the expression patterns of YME1L1 and related proteins were examined. It was found that YME1L1 is localized in the punctate structures of mitochondria and highly expressed from the 4-cell stage. Knocking down YME1L1 led to decreased blastocyst rate and quality, mitochondrial fragmentation, excessive ROS production, lower mitochondrial membrane potential and ATP levels. Moreover, YME1L1 knockdown induced OPA1 cleavage and cytochrome c release. These findings demonstrate that YME1L1 is crucial for regulating mitochondrial fission, function, and apoptosis during porcine embryo preimplantation development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama
Summary: Higher-intensity ultrasound and radial extracorporeal shock waves can accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation. Electrical stimulation does not affect the healing process.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Masayuki Morishita, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Takuya Fujimoto, Ikuo Fujita, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: Among 509 STS patients, 0.98% had brain metastasis (BM). The median survival after BM was 1.5 months. Combined surgery and postoperative radiotherapy were found to effectively manage symptoms and prolong survival in STS patients with BM.
ANTICANCER RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose
Summary: A patient with primary monophasic synovial sarcoma in the left thigh declined surgery and received two courses of BNCT, resulting in tumor reduction and complete resection without recurrence. Further research and analysis are needed to confirm BNCT efficacy for synovial sarcoma treatment.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Oncology
Hitomi Hara, Yoshitada Sakai, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Kenichiro Kakutani, Takahiro Niikura, Daisuke Miyawaki, Takuya Okada, Akihiro Sakashita, Yoshinori Imamura, Ryohei Sasaki, Yoshiyuki Kizawa, Hironobu Minami, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Toshihiro Akisue
Summary: Survival after surgical treatment for bone metastases was influenced by factors such as primary tumor, presence of visceral metastases, and type of surgical procedure. Surgical treatment for metastatic bone tumors effectively reduced pain and improved patient symptoms, activities of daily living, and quality of life after 3 months postoperatively.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Clinical Neurology
Yasutaka Nikaido, Hideyuki Urakami, Toshihiro Akisue, Yohei Okada, Yuki Kawami, Ishida Naoya, Kenji Kuroda, Hiroshi Ohno, Yoshinaga Kajimoto, Ryuichi Saura
Summary: The study evaluated changes in gait and balance function in patients with iNPH after CSF shunting. Results showed significant improvement in TUG and FGA scores postoperatively, especially in patients with TUG <15 seconds.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama
Summary: This study demonstrated that radial extracorporeal shock wave and ultrasound treatments can improve trabecular bone microarchitecture and bone strength in estrogen-deficient osteoporotic rats, while electrical stimulation had no significant effect. Shock wave decreased osteoclast activity and RANKL expression, while ultrasound increased osteoblast activity.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Clinical Neurology
Yasutaka Nikaido, Yohei Okada, Hideyuki Urakami, Naoya Ishida, Toshihiro Akisue, Yuki Kawami, Kenji Kuroda, Yoshinaga Kajimoto, Ryuichi Saura
Summary: Dynamic stability in iNPH increases in both anterior-posterior and medial-lateral directions, potentially due to cautious gait strategy. In contrast, dynamic stability in PD only increases in the anterior-posterior direction, likely related to PD symptoms. These differences in dynamic stability may provide valuable insights for physicians in understanding pathological gait patterns in iNPH and PD.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: The purpose of this study was to clarify the clinical outcomes and prognostic factors in patients with STS who underwent unplanned excision (UE). The results showed that there was no significant difference in overall survival, local recurrence-free survival, or disease-free survival between the UE and planned excision (PE) groups. However, metastasis-free survival was significantly better in the UE group. Older age and larger primary tumor were associated with poorer disease-free survival in the UE group.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Engineering, Biomedical
Yasutaka Nikaido, Hideyuki Urakami, Yohei Okada, Yoshinaga Kajimoto, Naoya Ishida, Yuki Kawami, Toshihiro Akisue, Ryuichi Saura
Summary: This study investigated whether dynamic gait stability differs between idiopathic normal-pressure hydrocephalus patients with high and low fall risks. The results showed that idiopathic normal-pressure hydrocephalus patients in both groups had larger anteroposterior and mediolateral margin of stabilities compared to healthy controls. The mediolateral margin of stability was significantly higher in the high-fall-risk group, indicating that these patients consciously maintained lateral stability to a greater extent. This study highlights the importance of conscious motor control in the pathological gait of idiopathic normal-pressure hydrocephalus.
CLINICAL BIOMECHANICS
(2022)
Article
Clinical Neurology
Yasutaka Nikaido, Hideyuki Urakami, Yohei Okada, Toshihiro Akisue, Yuki Kawami, Naoya Ishida, Yoshinaga Kajimoto, Ryuichi Saura
Summary: This study evaluated the rehabilitation effects of dynamic equilibrium gait training (DEGT) for patients with idiopathic normal pressure hydrocephalus (iNPH) who underwent cerebrospinal fluid (CSF) shunting, compared to standard exercise (SE) and no further treatment. The results showed that DEGT can improve gait-balance functions and reduce the fall incidence of iNPH patients after CSF shunting.
JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Ryoko Sawada, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Tomoaki Terakawa, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: The introduction of tyrosine kinase inhibitors has greatly improved treatment strategies for metastatic renal cell carcinoma (RCC) and increased survival rates. However, there is a lack of standardized treatment for bone metastases from RCC after targeted therapy. This study aimed to evaluate the outcomes of palliative surgical treatment for bone metastases in patients with advanced RCC and found that the postoperative results were positive, emphasizing the importance of systemic treatment over local control for advanced bone metastasis in RCC.
Article
Medicine, General & Internal
Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda
Summary: The number of advanced-age patients with spinal metastases is increasing. This study aimed to analyze the characteristics and outcomes of spinal metastases surgery in advanced-age patients. Prospective analysis of 216 patients divided into three age groups showed that patients aged ≥80 years had poorer performance status, Barthel index, and EQ-5D before and after surgery. Postoperative complications and EQ-5D re-deterioration rates were higher in the ≥80-year group. While surgery improved outcomes regardless of age, clinicians should consider the poorer outcomes and higher complication rates in advanced-age patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Hiroshi Urakawa, Akihito Nagano, Ryunosuke Machida, Kazuhiro Tanaka, Tomoko Kataoka, Yuta Sekino, Yoshihiro Nishida, Mitsuru Takahashi, Toshiyuki Kunisada, Masanori Kawano, Yukihiro Yoshida, Tatsuya Takagi, Kenji Sato, Toru Hiruma, Hiroshi Hatano, Satoshi Tsukushi, Akio Sakamoto, Toshihiro Akisue, Koji Hiraoka, Toshifumi Ozaki
Summary: The superiority of preoperative denosumab was not observed in terms of relapse-free survival in patients with giant cell tumor of bone without possible post-operative large bone defect.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Kazuyoshi Mitani, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Masayuki Morishita, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masato Komatsu, Naoe Jimbo, Ryosuke Kuroda, Toshihiro Akisue
Summary: Chondrolipoma is an extremely rare histological variant of lipoma characterized by the proliferation of mature adipocytes and true hyaline cartilage. This study presents a rare pediatric case occurring in the finger, with excellent postoperative outcomes and no local recurrence after three years.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)