Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

(2021) John A Spertus et al.   LANCET

Pathophysiology and Treatment of Hypertrophic Cardiomyopathy: New Perspectives

(2021) Mattia Zampieri et al.   Current Heart Failure Reports

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

(2021) Chihyuan Chuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy

(2021) Anne M. Dybro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy

(2020) Carolyn Y. Ho et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Iacopo Olivotto et al.   LANCET

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary

(2020) et al.   CIRCULATION

Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM CMR Substudy Analysis

(2020) Sara Saberi et al.   CIRCULATION

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

(2020) John R. Teerlink et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy

(2019) Stephen B. Heitner et al.   ANNALS OF INTERNAL MEDICINE

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

(2018) Carolyn Y. Ho et al.   CIRCULATION

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Hospital Volume Outcomes After Septal Myectomy and Alcohol Septal Ablation for Treatment of Obstructive Hypertrophic Cardiomyopathy

(2016) Luke K. Kim et al.   JAMA Cardiology

Short and Medium Term Outcomes of Surgery for Patients With Hypertrophic Obstructive Cardiomyopathy

(2015) Dominic J. Parry et al.   ANNALS OF THORACIC SURGERY

Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies

(2015) Barry J. Maron et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-Term Survival in Patients With Resting Obstructive Hypertrophic Cardiomyopathy

(2011) Warren Ball et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Current Effectiveness and Risks of Isolated Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy

(2007) Nicholas G. Smedira et al.   ANNALS OF THORACIC SURGERY