Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Characterization of the Cardiac Myosin Inhibitor CK-3773274: a Potential Therapeutic Approach for Hypertrophic Cardiomyopathy

(2020) James J. Hartman et al.   BIOPHYSICAL JOURNAL

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Iacopo Olivotto et al.   LANCET

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy

(2019) Stephen B. Heitner et al.   ANNALS OF INTERNAL MEDICINE

A First in Human Study of the Selective Cardiac Myosin Inhibitor, CK-3773274

(2019) Laura A. Robertson et al.   JOURNAL OF CARDIAC FAILURE

Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies

(2019) Osamu Tsukamoto   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevalence of clinically apparent hypertrophic cardiomyopathy in Germany—An analysis of over 5 million patients

(2018) Daniela Husser et al.   PLoS One

Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records

(2018) Mar Pujades-Rodriguez et al.   PLoS One

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

(2018) Mark P. Grillo et al.   XENOBIOTICA

Functional capacity in a rat model of heart failure: impact of myocardial infarct size

(2017) Vítor Scotta Hentschke et al.   EXPERIMENTAL PHYSIOLOGY

Misclassification of hypertrophic cardiomyopathy: validation of diagnostic codes

(2017) Peter Magnusson et al.   Clinical Epidemiology

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy

(2014)   EUROPEAN HEART JOURNAL

Insights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Serine 236,

(2010) Jeremiah J. Frye et al.   BIOCHEMISTRY