A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

(2016) I. Cohen et al.   BIOCHEMICAL JOURNAL

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

(2015) Simon J. de Veer et al.   BIOCHEMICAL JOURNAL

Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor

(2015) Peng Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

(2014) Jon A. Kenniston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity by Increasing Peptide Flexibility

(2014) Baoyu Zhao et al.   PLoS One

Allosteric Inactivation of a Trypsin-Like Serine Protease by An Antibody Binding to the 37- and 70-Loops

(2013) Tobias Kromann-Hansen et al.   BIOCHEMISTRY

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

(2013) Alexander W. Tarr et al.   HEPATOLOGY

High-affinity Cyclic Peptide Matriptase Inhibitors

(2013) Pedro Quimbar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Reverse Binding Motif That Contributes to Specific Protease Inhibition by Antibodies

(2011) Eric L. Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

TAFIa inhibiting nanobodies as profibrinolytic tools and discovery of a new TAFIa conformation

(2011) M. L. V. HENDRICKX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

(2011) Joakim E. Swedberg et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanisms of Macromolecular Protease Inhibitors

(2010) Christopher J. Farady  et al.   CHEMBIOCHEM

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin

(2010) Moh'd A. Salameh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular Proteases as Targets for Drug Development

(2009) Mare Cudic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Functional and Structural Roles of the Cys14–Cys38 Disulfide of Bovine Pancreatic Trypsin Inhibitor

(2008) Elena Zakharova et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition

(2008) Christopher J. Farady et al.   JOURNAL OF MOLECULAR BIOLOGY