Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model

Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms

(2020) Han-Ying Wang et al.   JOURNAL OF NEUROSCIENCE

Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes

(2020) The Mon La et al.   FASEB JOURNAL

Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-frequency Neurotransmission

(2019) Lashmi Piriya Ananda Babu et al.   JOURNAL OF NEUROSCIENCE

Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis

(2018) Shigeki Watanabe et al.   NEURON

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

Cryo-EM of the dynamin polymer assembled on lipid membrane

(2018) Leopold Kong et al.   NATURE

Distribution of endogenous normal tau in the mouse brain

(2018) Atsuko Kubo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held

(2017) Kohgaku Eguchi et al.   JOURNAL OF NEUROSCIENCE

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly

(2017) Tolga Soykan et al.   NEURON

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

Is Tau Aggregation Toxic or Protective: A Sensible Question in the Absence of Sensitive Methods?

(2017) Jürgen Götz et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

(2016) David J. Koss et al.   ACTA NEUROPATHOLOGICA

Impact of vesicular glutamate leakage on synaptic transmission at the calyx of Held

(2016) Chihiro Takami et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles

(2014) Ce Xie et al.   PLoS One

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Stabilization of Actin Bundles by a Dynamin 1/Cortactin Ring Complex Is Necessary for Growth Cone Filopodia

(2013) H. Yamada et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Fast neurotransmitter release regulated by the endocytic scaffold intersectin

(2013) T. Sakaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets

(2013) V. M.-Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Kinetics of Synaptic Vesicle Refilling with Neurotransmitter Glutamate

(2012) Tetsuya Hori et al.   NEURON

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Overlapping Role of Dynamin Isoforms in Synaptic Vesicle Endocytosis

(2011) Andrea Raimondi et al.   NEURON

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Direct dynamin–actin interactions regulate the actin cytoskeleton

(2010) Changkyu Gu et al.   EMBO JOURNAL

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Formins and microtubules

(2009) F. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant

(2009) Kenji Tanabe et al.   JOURNAL OF CELL BIOLOGY

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

(2008) Jeffrey A. Fein et al.   AMERICAN JOURNAL OF PATHOLOGY

Axonal Transport Rates In Vivo Are Unaffected by Tau Deletion or Overexpression in Mice

(2008) A. Yuan et al.   JOURNAL OF NEUROSCIENCE

Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching

(2008) Or A. Shemesh et al.   TRAFFIC