Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

(2022) Minghui Zhang et al.   Frontiers in Immunology

Current understanding of biological identity at the nanoscale and future prospects

(2021) Kenneth A. Dawson et al.   Nature Nanotechnology

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

(2021) William Peeples et al.   Nature Chemical Biology

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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

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Unusual zymogen activation patterns in the protein corona of Ca-zeolites

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Transforming the spleen into a liver-like organ in vivo

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A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Monomeric and homotrimeric solution structures of truncated human peroxidasin 1 variants

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Lung cancer in patients with Idiopathic Pulmonary Fibrosis. A retrospective multicenter study in Greece

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Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation

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Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells

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The Immune Landscape of Cancer

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Targeting the tumour stroma to improve cancer therapy

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Protein Phase Separation: A New Phase in Cell Biology

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Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

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Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

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Building collagen IV smart scaffolds on the outside of cells

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Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

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Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane

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Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action

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Mutational signatures associated with tobacco smoking in human cancer

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Corona-Directed Nucleic Acid Delivery into Hepatic Stellate Cells for Liver Fibrosis Therapy

(2015) Zhengping Zhang et al.   ACS Nano

Crystal structure analysis of peroxidase from the palm tree Chamaerops excelsa

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Structure–function analysis of peroxidasin provides insight into the mechanism of collagen IV crosslinking

(2015) Enikő Lázár et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multidomain Human Peroxidasin 1 Is a Highly Glycosylated and Stable Homotrimeric High Spin Ferric Peroxidase

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Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization

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(2015) J. A. Joyce et al.   SCIENCE

Real-Time Imaging of Resident T Cells in Human Lung and Ovarian Carcinomas Reveals How Different Tumor Microenvironments Control T Lymphocyte Migration

(2015) Houcine Bougherara et al.   Frontiers in Immunology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

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Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

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Mechanisms underlying mutational signatures in human cancers

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Antioxidants Accelerate Lung Cancer Progression in Mice

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Epidemiological time series studies of PM2.5and daily mortality and hospital admissions: a systematic review and meta-analysis

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Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution

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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

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Vascular peroxidase 1 catalyzes the formation of hypohalous acids: Characterization of its substrate specificity and enzymatic properties

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Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

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A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

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Tying the collagen-sulfilimine knot

(2012) Stephen J Weiss   Nature Chemical Biology

Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis

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Biomolecular coronas provide the biological identity of nanosized materials

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Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

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Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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Cell-autonomous and environmental contributions to the interstitial migration of T cells

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Peroxidasin Is Secreted and Incorporated into the Extracellular Matrix of Myofibroblasts and Fibrotic Kidney

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Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

A Sulfilimine Bond Identified in Collagen IV

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The effect of particle design on cellular internalization pathways

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