Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

Cognitive control persistently enhances hippocampal information processing

(2021) Ain Chung et al.   NATURE

Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome

(2020) Conny H. Tran et al.   JOURNAL OF NEUROSCIENCE

CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice

(2020) Tetsushi Yamagata et al.   NEUROBIOLOGY OF DISEASE

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

(2020) Zhou Han et al.   Science Translational Medicine

Disordered autonomic function during exposure to moderate heat or exercise in a mouse model of Dravet syndrome

(2020) Nikhil Sahai et al.   NEUROBIOLOGY OF DISEASE

A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies

(2019) Ana Rita Salgueiro-Pereira et al.   NEUROBIOLOGY OF DISEASE

Analysis pipelines for calcium imaging data

(2019) Eftychios A Pnevmatikakis   CURRENT OPINION IN NEUROBIOLOGY

Spontaneous behaviors drive multidimensional, brainwide activity

(2019) Carsen Stringer et al.   SCIENCE

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

(2019) Hod Dana et al.   NATURE METHODS

Thermal constraints on in vivo optogenetic manipulations

(2019) Scott F. Owen et al.   NATURE NEUROSCIENCE

Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering

(2019) Yudong Gao et al.   NEURON

Hippocampal deletion of NaV1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome

(2019) Rachael E. Stein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

(2019) Kevin M Goff et al.   eLife

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Activation of Entorhinal Cortical Projections to the Dentate Gyrus Underlies Social Memory Retrieval

(2018) Celeste Leung et al.   Cell Reports

Mesial Temporal Sclerosis in SCN1A-Related Epilepsy: Two Long-Term EEG Case Studies

(2018) Anna M. Tiefes et al.   CLINICAL EEG AND NEUROSCIENCE

Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy

(2018) Jie-Hua Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome

(2018) Morgana Favero et al.   JOURNAL OF NEUROSCIENCE

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

(2018) Kay L. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dravet syndrome: Characteristics, comorbidities, and caregiver concerns

(2017) Nicole Villas et al.   EPILEPSY & BEHAVIOR

Early-life febrile seizures worsen adult phenotypes in Scn1a mutants

(2017) Stacey B.B. Dutton et al.   EXPERIMENTAL NEUROLOGY

Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures

(2017) Sattar Khoshkhoo et al.   NEURON

Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells

(2017) Yuta Senzai et al.   NEURON

Pharmacology of the Na v 1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

(2017) Jeremiah D. Osteen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comparison of Different Slicing Planes in Preservation of Major Hippocampal Pathway Fibers in the Mouse

(2017) Guoxiang Xiong et al.   Frontiers in Neuroanatomy

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

(2017) Nicole A. Hawkins et al.   Annals of Clinical and Translational Neurology

Massively augmented hippocampal dentate granule cell activation accompanies epilepsy development

(2017) Christopher G. Dengler et al.   Scientific Reports

Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy

(2016) Angela Michela De Stasi et al.   CEREBRAL CORTEX

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data

(2016) Eftychios A. Pnevmatikakis et al.   NEURON

Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

(2016) Yi Lu et al.   Nature Communications

Causal Evidence for the Role of Specific GABAergic Interneuron Types in Entorhinal Recruitment of Dentate Granule Cells

(2016) Cheng-Ta Lee et al.   Scientific Reports

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

(2016) Yishan Sun et al.   eLife

Sparse activity of identified dentate granule cells during spatial exploration

(2016) Maria Diamantaki et al.   eLife

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

In vivoevaluation of the dentate gate theory in epilepsy

(2015) Esther Krook-Magnuson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development

(2015) Ming-Shian Tsai et al.   NEUROBIOLOGY OF DISEASE

Purinergic control of hippocampal circuit hyperexcitability in Dravet syndrome

(2014) Feng Gu et al.   EPILEPSIA

Rapid Dynamic Changes of Dendritic Inhibition in the Dentate Gyrus by Presynaptic Activity Patterns

(2014) Y.-C. Liu et al.   JOURNAL OF NEUROSCIENCE

Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation

(2014) U. B. S. Hedrich et al.   JOURNAL OF NEUROSCIENCE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Quantum dot–based multiphoton fluorescent pipettes for targeted neuronal electrophysiology

(2014) Bertalan K Andrásfalvy et al.   NATURE METHODS

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

(2014) C. Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

(2013) Yu Liu et al.   ANNALS OF NEUROLOGY

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A

(2013) Dalia Kasperavičiūtė et al.   BRAIN

Hippocampal hyperexcitability and specific epileptiform activity in a mouse model of Dravet syndrome

(2013) Camille Liautard et al.   EPILEPSIA

Dravet syndrome: New potential genetic modifiers, imaging abnormalities, and ictal findings

(2013) Eija Gaily et al.   EPILEPSIA

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

(2013) A. R. Miller et al.   GENES BRAIN AND BEHAVIOR

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

(2013) Ikuo Ogiwara et al.   HUMAN MOLECULAR GENETICS

Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons

(2013) Jiao Jiao et al.   HUMAN MOLECULAR GENETICS

Distinct Determinants of Sparse Activation during Granule Cell Maturation

(2013) C. V. Dieni et al.   JOURNAL OF NEUROSCIENCE

Protracted Postnatal Development of Sparse, Specific Dentate Granule Cell Activation in the Mouse Hippocampus

(2013) E. P. Yu et al.   JOURNAL OF NEUROSCIENCE

Electrophysiological identification of medial and lateral perforant path inputs to the dentate gyrus

(2013) R.P. Petersen et al.   NEUROSCIENCE

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Mesial Temporal Sclerosis in a Cohort of Children With SCN1A Gene Mutation

(2012) Katherine Van Poppel et al.   JOURNAL OF CHILD NEUROLOGY

Spatial Firing Correlates of Physiologically Distinct Cell Types of the Rat Dentate Gyrus

(2012) J. P. Neunuebel et al.   JOURNAL OF NEUROSCIENCE

GABA Is Depolarizing in Hippocampal Dentate Granule Cells of the Adolescent and Adult Rats

(2012) P.-H. Chiang et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

(2012) Stacey B. Dutton et al.   NEUROBIOLOGY OF DISEASE

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pure haploinsufficiency for Dravet syndrome NaV1.1 (SCN1A) sodium channel truncating mutations

(2011) Giulia Bechi et al.   EPILEPSIA

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic Integration in Hippocampal Dentate Granule Cells

(2011) Roland Krueppel et al.   NEURON

A computational theory of episodic memory formation in the hippocampus

(2010) Edmund T. Rolls   BEHAVIOURAL BRAIN RESEARCH

Frequency-Tuned Distribution of Inhibition in the Dentate Gyrus

(2010) L. A. Ewell et al.   JOURNAL OF NEUROSCIENCE

Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy

(2009) J. C. Oakley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential dendritic Ca2+signalling in young and mature hippocampal granule cells

(2008) Gabriella Stocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

What is the mammalian dentate gyrus good for?

(2008) A. Treves et al.   NEUROSCIENCE