The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity

(2021) Joshua L. Justice et al.   Science Advances

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection

(2021) Krystal K. Lum et al.   CURRENT ISSUES IN MOLECULAR BIOLOGY

The journey of herpesvirus capsids and genomes to the host cell nucleus

(2021) Katinka Döhner et al.   Current Opinion in Virology

Assembly of infectious Kaposi’s sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer

(2021) Peter Naniima et al.   PLOS BIOLOGY

The anti-viral dynamin family member MxB participates in mitochondrial integrity

(2020) Hong Cao et al.   Nature Communications

The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection

(2020) Milagros Collados Rodríguez et al.   VIRUS RESEARCH

GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity

(2020) Linlin Xie et al.   VIROLOGICA SINICA

Viral entry and the ubiquitin‐proteasome system

(2020) Seth M. Schneider et al.   CELLULAR MICROBIOLOGY

Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA

(2020) Rebecca P Sumner et al.   EMBO JOURNAL

The Gene Ontology resource: enriching a GOld mine

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The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection

(2019) Jorge Ruben Cabrera et al.   mBio

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

(2019) Philipp Hubel et al.   NATURE IMMUNOLOGY

Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

(2019) Markus Stempel et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

(2019) Chenglong Sun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome

(2019) Yun-Tao Liu et al.   NATURE

MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid

(2019) Sarah Sierra Smaga et al.   STRUCTURE

Toward understanding the origin and evolution of cellular organisms

(2019) Minoru Kanehisa   PROTEIN SCIENCE

Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

(2019) Alberto Brandariz-Nuñez et al.   eLife

The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction

(2019) Gilberto Betancor et al.   Cell Reports

Human MxB protein is a pan-herpesvirus restriction factor

(2018) Mirjam Schilling et al.   JOURNAL OF VIROLOGY

Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes

(2018) Xinghong Dai et al.   SCIENCE

MXB inhibits murine cytomegalovirus

(2018) Ananda Ayyappann Jaguva Vasudevan et al.   VIROLOGY

MxB is an interferon-induced restriction factor of human herpesviruses

(2018) Michel Crameri et al.   Nature Communications

Structure of the herpes simplex virus portal-vertex

(2018) Marion McElwee et al.   PLOS BIOLOGY

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

(2018) Katinka Döhner et al.   PLoS Pathogens

RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections

(2018) Madalina E. Carter-Timofte et al.   TRENDS IN MOLECULAR MEDICINE

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

(2018) Melissa Kane et al.   eLife

Innate Sensing of DNA Virus Genomes

(2018) Zhe Ma et al.   Annual Review of Virology

Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1

(2018) Aykut Turan et al.   JOURNAL OF CELL BIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A pUL25 dimer interfaces the pseudorabies virus capsid and tegument

(2017) Yun-Tao Liu et al.   JOURNAL OF GENERAL VIROLOGY

Vertex-Specific Proteins pUL17 and pUL25 Mechanically Reinforce Herpes Simplex Virus Capsids

(2017) Joost Snijder et al.   JOURNAL OF VIROLOGY

Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET

(2017) Yang Chen et al.   Nature Communications

CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction

(2017) Frances J. D. Alvarez et al.   Science Advances

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Contribution of MxB Oligomerization to HIV-1 Capsid Binding and Restriction

(2015) Cindy Buffone et al.   JOURNAL OF VIROLOGY

Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal

(2015) Bianca Schulte et al.   JOURNAL OF VIROLOGY

Dynamic ubiquitination drives herpesvirus neuroinvasion

(2015) Nicholas J. Huffmaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

Conserved tegument protein complexes: Essential components in the assembly of herpesviruses

(2015) Russell J. Diefenbach   VIRUS RESEARCH

Varicella zoster virus infection

(2015) Anne A. Gershon et al.   Nature Reviews Disease Primers

Structural Insight into HIV-1 Restriction by MxB

(2014) Jennifer L. Fribourgh et al.   Cell Host & Microbe

Transfer of the Amino-Terminal Nuclear Envelope Targeting Domain of Human MX2 Converts MX1 into an HIV-1 Resistance Factor

(2014) C. Goujon et al.   JOURNAL OF VIROLOGY

Major capsid reinforcement by a minor protein in herpesviruses and phage

(2014) Udom Sae-Ueng et al.   NUCLEIC ACIDS RESEARCH

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

(2014) Thomas Fricke et al.   Retrovirology

Targeting of Viral Capsids to Nuclear Pores in a Cell-Free Reconstitution System

(2014) Fenja Anderson et al.   TRAFFIC

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

(2013) Gabriela Bindea et al.   BIOINFORMATICS

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

Herpes Virus Genome, The Pressure Is On

(2013) David W. Bauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Cytosolic herpes simplex virus capsids not only require binding inner tegument protein pUL36 but also pUL37 for active transport prior to secondary envelopment

(2012) Malte Sandbaumhüter et al.   CELLULAR MICROBIOLOGY

The C Terminus of the Large Tegument Protein pUL36 Contains Multiple Capsid Binding Sites That Function Differently during Assembly and Cell Entry of Herpes Simplex Virus

(2012) J. Schipke et al.   JOURNAL OF VIROLOGY

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Systematic identification of type I and type II interferon-induced antiviral factors

(2012) S.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function

(2011) Song Gao et al.   IMMUNITY

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment

(2011) H. L. Zenner et al.   JOURNAL OF VIROLOGY

Uncoupling Uncoating of Herpes Simplex Virus Genomes from Their Nuclear Import and Gene Expression

(2011) K. Rode et al.   JOURNAL OF VIROLOGY

The Virion Host Shutoff Endonuclease (UL41) of Herpes Simplex Virus Interacts with the Cellular Cap-Binding Complex eIF4F

(2010) H. G. Page et al.   JOURNAL OF VIROLOGY

Plus- and Minus-End Directed Microtubule Motors Bind Simultaneously to Herpes Simplex Virus Capsids Using Different Inner Tegument Structures

(2010) Kerstin Radtke et al.   PLoS Pathogens

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Scaffold expulsion and genome packaging trigger stabilization of herpes simplex virus capsids

(2009) W. H. Roos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens

(2008) I. Engelmann et al.   JOURNAL OF MEDICAL VIROLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH