Protein Scaffolds Control Localized Protein Kinase Cζ Activity

IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation

(2016) Gang Xi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Protein kinase C  exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation

(2015) I. S. Tobias et al.   BIOCHEMICAL JOURNAL

Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle

(2015) Gang Xi et al.   FASEB JOURNAL

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62

(2015) Li-Chun Lisa Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

(2014) Frank Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intramolecular Conformational Changes Optimize Protein Kinase C Signaling

(2014) Corina E. Antal et al.   CHEMISTRY & BIOLOGY

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF  in glioblastoma

(2014) Y. Kusne et al.   Science Signaling

Protein kinase C pharmacology: refining the toolbox

(2013) Alyssa X. Wu-zhang et al.   BIOCHEMICAL JOURNAL

Shedding light on local kinase activation

(2012) John D Scott et al.   BMC BIOLOGY

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Isozyme-specific Interaction of Protein Kinase Cδ with Mitochondria Dissected Using Live Cell Fluorescence Imaging

(2012) Alyssa X. Wu-Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Partitioning-defective Protein 6 (Par-6) Activates Atypical Protein Kinase C (aPKC) by Pseudosubstrate Displacement

(2012) Chiharu Graybill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Itsin VitroProfile

(2012) Alyssa X. Wu-Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein

(2012) Thangiah Geetha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC

(2010) Naoto Hoshi et al.   MOLECULAR CELL

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

The α-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice

(2009) Kosuke Okada et al.   HEPATOLOGY RESEARCH

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor

(2008) John I. Trujillo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1, -3, and -4 But Not -2: Isoform Specific Determinants of Specificity in Insulin Signaling

(2008) Sihoon Lee et al.   ENDOCRINOLOGY