A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

(2015) Chihiro Motozono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

(2015) Henrik N Kløverpris et al.   Retrovirology

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

(2014) Florian Madura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT

(2013) Niels Schaft et al.   Frontiers in Immunology

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TCR/pMHC Optimized Protein crystallization Screen

(2012) Anna M. Bulek et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Monoclonal TCR-redirected tumor cell killing

(2012) Nathaniel Liddy et al.   NATURE MEDICINE

Structural and biophysical determinants of αβ T-cell antigen recognition

(2011) John S. Bridgeman et al.   IMMUNOLOGY

TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

(2011) O. Y. Borbulevych et al.   JOURNAL OF IMMUNOLOGY

Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used

(2010) W. Joost Lesterhuis et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

(2010) D. K. Cole et al.   JOURNAL OF IMMUNOLOGY

Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability

(2010) Kim M. Miles et al.   MOLECULAR IMMUNOLOGY

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

(2009) Oleg Y. Borbulevych et al.   IMMUNITY

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Thermodynamics of T‐cell receptor–peptide/MHC interactions: progress and opportunities

(2008) Kathryn M. Armstrong et al.   JOURNAL OF MOLECULAR RECOGNITION

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

(2008) D. E. Speiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA