Recycled Translation: Repurposing Drugs for Stroke

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Identification of disease treatment mechanisms through the multiscale interactome

(2021) Camilo Ruiz et al.   Nature Communications

Drug Repurposing for Parkinson’s Disease: The International Linked Clinical Trials experience

(2021) Simon R. W. Stott et al.   Frontiers in Neuroscience

How Much Does It Cost to Research and Develop a New Drug? A Systematic Review and Assessment

(2021) Michael Schlander et al.   PHARMACOECONOMICS

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2021) Valery L Feigin et al.   LANCET NEUROLOGY

PreBINDS: An Interactive Web Tool to Create Appropriate Datasets for Predicting Compound–Protein Interactions

(2021) Kazuyoshi Ikeda et al.   Frontiers in Molecular Biosciences

Twenty Years of Progress Toward Understanding the Stroke Belt

(2020) George Howard et al.   STROKE

Drug repositioning and repurposing for Alzheimer disease

(2020) Clive Ballard et al.   Nature Reviews Neurology

PROMISCUOUS 2.0: a resource for drug-repositioning

(2020) Kathleen Gallo et al.   NUCLEIC ACIDS RESEARCH

Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats

(2020) Zikra Zulfiqar et al.   Journal of Inflammation Research

Intravenous Magnesium Sulfate in Acute Stroke

(2019) Konstantinos I. Avgerinos et al.   STROKE

Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents

(2019) Antje Schmidt‐Pogoda et al.   ANNALS OF NEUROLOGY

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Thoughts on improving medication use

(2018) Gary D. Novack   Ocular Surface

Drug Repurposing in Parkinson’s Disease

(2018) Dilan Athauda et al.   CNS DRUGS

Increasing the Participation of Pregnant Women in Clinical Trials

(2018) Katrina Heyrana et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Under-representation of elderly and women in clinical trials

(2017) Cristiana Vitale et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

Minocycline in Acute Cerebral Hemorrhage

(2017) Abdelrahman Y. Fouda et al.   STROKE

Analysis of Review Times for Recent 505(b)(2) Applications

(2017) Sharon Sakai et al.   Therapeutic Innovation & Regulatory Science

On the Integration of In Silico Drug Design Methods for Drug Repurposing

(2017) Eric March-Vila et al.   Frontiers in Pharmacology

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

(2017) J. Javier Hernandez et al.   Frontiers in Oncology

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures

(2017) Hongyu Wu et al.   PLoS One

RANKS: a flexible tool for node label ranking and classification in biological networks

(2016) Giorgio Valentini et al.   BIOINFORMATICS

ksRepo: a generalized platform for computational drug repositioning

(2016) Adam S. Brown et al.   BMC BIOINFORMATICS

Locating rearrangement events in a phylogeny based on highly fragmented assemblies

(2016) Chunfang Zheng et al.   BMC GENOMICS

Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials

(2016) Julio J. Secades et al.   Journal of Stroke & Cerebrovascular Diseases

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

ALIAS (Albumin in Acute Ischemic Stroke) Trials

(2016) Renee’ H. Martin et al.   STROKE

The drug-minded protein interaction database (DrumPID) for efficient target analysis and drug development

(2016) Meik Kunz et al.   Database-The Journal of Biological Databases and Curation

The High Cost of Stroke and Stroke Cytoprotection Research

(2016) Paul A. Lapchak et al.   Translational Stroke Research

Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials

(2016) Julio J. Secades et al.   Journal of Stroke & Cerebrovascular Diseases

Global optimization-based inference of chemogenomic features from drug–target interactions

(2015) Songpeng Zu et al.   BIOINFORMATICS

DSigDB: drug signatures database for gene set analysis: Fig. 1.

(2015) Minjae Yoo et al.   BIOINFORMATICS

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

NFFinder: an online bioinformatics tool for searching similar transcriptomics experiments in the context of drug repositioning

(2015) Javier Setoain et al.   NUCLEIC ACIDS RESEARCH

REVASCAT Trial

(2015) Wade S. Smith et al.   STROKE

Comprehensive prediction of drug-protein interactions and side effects for the human proteome

(2015) Hongyi Zhou et al.   Scientific Reports

Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis

(2014) D. Carrella et al.   BIOINFORMATICS

MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial

(2014) Puck SS Fransen et al.   Trials

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Minocycline Development for Acute Ischemic Stroke

(2011) Susan C. Fagan et al.   Translational Stroke Research

PROMISCUOUS: a database for network-based drug-repositioning

(2010) J. von Eichborn et al.   NUCLEIC ACIDS RESEARCH

Drug Repurposing for Drug Development in Stroke

(2010) Susan C Fagan   PHARMACOTHERAPY

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA)

(2009) Justin A. Zivin   ANNALS OF NEUROLOGY

Pharmacogenetics in drug discovery and development: a translational perspective

(2008) Allen D. Roses   NATURE REVIEWS DRUG DISCOVERY