Central Role of Pyruvate Kinase in Carbon Co-catabolism ofMycobacterium tuberculosis

The DosR Regulon Modulates Adaptive Immunity and Is Essential forMycobacterium tuberculosisPersistence

(2015) Smriti Mehra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Essential roles of methionine andS-adenosylmethionine in the autarkic lifestyle ofMycobacterium tuberculosis

(2015) Michael Berney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E1 of α-ketoglutarate dehydrogenase defendsMycobacterium tuberculosisagainst glutamate anaplerosis and nitroxidative stress

(2015) Christina Maksymiuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

(2014) J. H. van Heerden et al.   SCIENCE

Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in Mycobacterium tuberculosis

(2014) P. Jain et al.   mBio

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

(2014) Anil Koul et al.   Nature Communications

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

(2014) Madhumitha Nandakumar et al.   Nature Communications

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

Extraction, derivatization, and determination of metabolome in human macrophages

(2013) Jianhua Cheng et al.   JOURNAL OF SEPARATION SCIENCE

Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia

(2013) Wai Yee Phong et al.   PLoS One

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organism-Adapted Specificity of the Allosteric Regulation of Pyruvate Kinase in Lactic Acid Bacteria

(2013) Nadine Veith et al.   PLoS Computational Biology

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

(2013) Joeli Marrero et al.   PLoS Pathogens

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation

(2012) Yi-Fan Xu et al.   MOLECULAR CELL

Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia

(2012) Michael Berney et al.   MOLECULAR MICROBIOLOGY

Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase

(2012) Yi-Fan Xu et al.   Nature Chemical Biology

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target

(2011) Roya Zoraghi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolic Profiling of Lung Granuloma inMycobacterium tuberculosisInfected Guinea Pigs: Ex vivo1H Magic Angle Spinning NMR Studies

(2011) B. S. Somashekar et al.   JOURNAL OF PROTEOME RESEARCH

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

(2011) Dany J. V. Beste et al.   PLoS Pathogens

Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-ResistantStaphylococcus aureus

(2010) Roya Zoraghi et al.   BIOCHEMISTRY

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

(2010) S. L. Kendall et al.   MICROBIOLOGY-SGM

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Global Effects of Inactivation of the Pyruvate Kinase Gene in the Mycobacterium tuberculosis Complex

(2009) S. Chavadi et al.   JOURNAL OF BACTERIOLOGY

Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

(2009) Katherine C. Yam et al.   PLoS Pathogens

A feed-forward loop guarantees robust behavior in Escherichia coli carbohydrate uptake

(2008) A. Kremling et al.   BIOINFORMATICS

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY