CTP sensing and Mec1ATR-Rad53CHK1/CHK2 mediate a two-layered response to inhibition of glutamine metabolism

Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions

(2021) Luca Zardoni et al.   NUCLEIC ACIDS RESEARCH

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

(2020) Lukas Gorecki et al.   PHARMACOLOGY & THERAPEUTICS

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

(2020) Dean C. Singleton et al.   BMC CANCER

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

(2020) Romain Forey et al.   MOLECULAR CELL

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

(2020) Christopher Bruhn et al.   Nature Communications

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

(2019) Maria Raimondi et al.   MOLECULES

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells

(2019) Larissa Menezes dos Reis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

Evaluation of an untargeted nano-liquid chromatography-mass spectrometry approach to expand coverage of low molecular weight dissolved organic matter in Arctic soil

(2019) Mallory P. Ladd et al.   Scientific Reports

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

(2019) Allison R. Hanaford et al.   Translational Oncology

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

(2019) Michael J. Lukey et al.   Cell Reports

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

(2019) Alyncia D. Robinson et al.   CANCER LETTERS

Leflunomide: A promising drug with good antitumor potential

(2018) Chunying Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine

(2018) Kathryn M. Lemberg et al.   MOLECULAR CANCER THERAPEUTICS

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Erratum: Cancer metabolism: a therapeutic perspective

(2017) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Alterations in cellular metabolism triggered byURA7orGLN3inactivation cause imbalanced dNTP pools and increased mutagenesis

(2017) Tobias T. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

(2017) Thai Q. Tran et al.   PLOS BIOLOGY

Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome

(2017) Xin Chen et al.   PLoS Genetics

FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition

(2017) Céline Barthelemy et al.   Scientific Reports

Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5′-Triphosphate

(2016) Gregory D. McCluskey et al.   CHEMBIOCHEM

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer

(2015) Masaru Matsumoto et al.   BMC CANCER

IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

(2015) Andres J. Lopez-Contreras et al.   GENES & DEVELOPMENT

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers

(2015) Teeru Bihani et al.   Oncotarget

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

gitter: A Robust and Accurate Method for Quantification of Colony Sizes From Plate Images

(2014) Omar Wagih et al.   G3-Genes Genomes Genetics

Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer

(2013) Amr Mohamed et al.   Clinical Lung Cancer

Therapeutic strategies impacting cancer cell glutamine metabolism

(2013) Michael J Lukey et al.   Future Medicinal Chemistry

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Expanding Targets for a Metabolic Therapy of Cancer: L-Asparaginase

(2011) Daniele Covini et al.   Recent Patents on Anti-Cancer Drug Discovery

Characterization of the activation domain of the Rad53 checkpoint kinase

(2010) Simona Fiorani et al.   CELL CYCLE

Identification of novel filament-forming proteins inSaccharomyces cerevisiaeandDrosophila melanogaster

(2010) Chalongrat Noree et al.   JOURNAL OF CELL BIOLOGY

Intracellular compartmentation of CTP synthase in Drosophila

(2010) Ji-Long Liu   Journal of Genetics and Genomics

The metabolic enzyme CTP synthase forms cytoskeletal filaments

(2010) Michael Ingerson-Mahar et al.   NATURE CELL BIOLOGY

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Quantitation of cellular deoxynucleoside triphosphates

(2009) Paola Ferraro et al.   NUCLEIC ACIDS RESEARCH

Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways

(2008) Marta Kwapisz et al.   EMBO JOURNAL

Properties of an Intergenic Terminator and Start Site Switch That Regulate IMD2 Transcription in Yeast

(2008) M. H. Jenks et al.   MOLECULAR AND CELLULAR BIOLOGY

Futile Cycle of Transcription Initiation and Termination Modulates the Response to Nucleotide Shortage in S. cerevisiae

(2008) Marilyne Thiebaut et al.   MOLECULAR CELL

Regulation of a Eukaryotic Gene by GTP-Dependent Start Site Selection and Transcription Attenuation

(2008) Jason N. Kuehner et al.   MOLECULAR CELL