Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5′-Triphosphate

Synthesis of Nucleoside Triphosphates from 2′-3′-Protected Nucleosides Using Trimetaphosphate

(2016) Samy Mohamady et al.   ORGANIC LETTERS

Inhibition of thymidylate synthase by 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine) and its metabolite 2′,2′-difluoro-2′-deoxyuridine

(2015) Richard J. Honeywell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo

(2014) T E Bapiro et al.   BRITISH JOURNAL OF CANCER

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

Engineered cytidine triphosphate synthetase with reduced product inhibition

(2014) M. Zhu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structure of the dimeric form of CTP synthase fromSulfolobus solfataricus

(2011) Iben Lauritsen et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness

(2011) Craig H. Steeves et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor

(2010) Paola Conti et al.   ChemMedChem

Mutational analysis of conserved glycine residues 142, 143 and 146 reveals Gly142is critical for tetramerization of CTP synthase fromEscherichia coli

(2008) Faylene A. Lunn et al.   BIOCHEMICAL JOURNAL

Ground State, Intermediate, and Multivalent Nucleotide Analogue Inhibitors of Cytidine 5′-Triphosphate Synthase

(2008) Scott D. Taylor et al.   ChemMedChem

Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study

(2008) S. A. Veltkamp et al.   CLINICAL CANCER RESEARCH

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

(2008) S. A. Veltkamp et al.   MOLECULAR CANCER THERAPEUTICS