Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions

Ultraviolet-induced RNA:DNA hybrids interfere with chromosomal DNA synthesis

(2021) Elena A Kouzminova et al.   NUCLEIC ACIDS RESEARCH

Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts

(2021) Kevin S. Lang et al.   Cell Reports

Harmful R-loops are prevented via different cell cycle-specific mechanisms

(2021) Marta San Martin-Alonso et al.   Nature Communications

Negative supercoil at gene boundaries modulates gene topology

(2020) Yathish Jagadheesh Achar et al.   NATURE

Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

(2020) Rowin Appanah et al.   Cell Reports

Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity

(2020) Chetan C. Rawal et al.   Cell Reports

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

(2020) Alexy Promonet et al.   Nature Communications

Protective Mechanisms Against DNA Replication Stress in the Nervous System

(2020) Clara Forrer Charlier et al.   Genes

Replisome bypass of transcription complexes and R-loops

(2020) Jan-Gert Brüning et al.   NUCLEIC ACIDS RESEARCH

Causes and consequences of RNA polymerase II stalling during transcript elongation

(2020) Melvin Noe Gonzalez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct removal of RNA polymerase barriers to replication by accessory replicative helicases

(2019) Michelle Hawkins et al.   NUCLEIC ACIDS RESEARCH

Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

(2019) Steffi Herold et al.   NATURE

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD

(2019) Lindsey D. Goodman et al.   NATURE NEUROSCIENCE

Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability

(2019) Jessica L. Feldman et al.   Cell Reports

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

(2019) Diana Zatreanu et al.   MOLECULAR CELL

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

(2019) Nagaraja Chappidi et al.   MOLECULAR CELL

RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

(2019) Arianna Lockhart et al.   Cell Reports

R-loops: targets for nuclease cleavage and repeat instability

(2018) Catherine H. Freudenreich   CURRENT GENETICS

Yra1-bound RNA–DNA hybrids cause orientation-independent transcription–replication collisions and telomere instability

(2018) María García-Rubio et al.   GENES & DEVELOPMENT

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

(2018) Christopher Grunseich et al.   MOLECULAR CELL

RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication

(2018) Alexander J Neil et al.   NUCLEIC ACIDS RESEARCH

Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy

(2018) Annapoorna Kannan et al.   NUCLEIC ACIDS RESEARCH

When DNA Topology Turns Deadly – RNA Polymerases Dig in Their R-Loops to Stand Their Ground: New Positive and Negative (Super)Twists in the Replication–Transcription Conflict

(2018) Andrei Kuzminov   TRENDS IN GENETICS

Chromatin conformation regulates the coordination between DNA replication and transcription

(2018) Ricardo Almeida et al.   Nature Communications

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin

(2018) Julien Brustel et al.   Scientific Reports

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

(2018) Mahmud K.K. Shivji et al.   Cell Reports

Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

(2018) Lorenzo Costantino et al.   MOLECULAR CELL

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

R‐loop formation during S phase is restricted by PrimPol‐mediated repriming

(2018) Saša Šviković et al.   EMBO JOURNAL

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells

(2017) Andrew Nickless et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

(2017) Matthias Groh et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants of Histone H3K4 Methylation Patterns

(2017) Luis M. Soares et al.   MOLECULAR CELL

Histone Mutants Separate R Loop Formation from Genome Instability Induction

(2017) Desiré García-Pichardo et al.   MOLECULAR CELL

SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication

(2017) Nitika Taneja et al.   MOLECULAR CELL

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription

(2017) Alessandra Brambati et al.   NUCLEIC ACIDS RESEARCH

Aggregation of the Whi3 protein, not loss of heterochromatin, causes sterility in old yeast cells

(2017) Gavin Schlissel et al.   SCIENCE

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

(2017) Xiaowen Zhang et al.   Nature Communications

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress

(2016) Jérôme Poli et al.   GENES & DEVELOPMENT

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

(2016) Peter Zeller et al.   NATURE GENETICS

Nonsense-mediated decay regulates key components of homologous recombination

(2016) Ryan Janke et al.   NUCLEIC ACIDS RESEARCH

Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination

(2016) Zhong Han et al.   NUCLEIC ACIDS RESEARCH

Differential roles of the RNases H in preventing chromosome instability

(2016) Anjali D. Zimmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

(2016) N. J. Kramer et al.   SCIENCE

Nascent Connections: R-Loops and Chromatin Patterning

(2016) Frédéric Chédin   TRENDS IN GENETICS

How cells kill a "killer" messenger

(2016) Cosmin Saveanu et al.   eLife

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

Pcf11 orchestrates transcription termination pathways in yeast

(2015) Pawel Grzechnik et al.   GENES & DEVELOPMENT

Structure–function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2

(2015) Shoudeng Chen et al.   GENES & DEVELOPMENT

Saccharomyces cerevisiaeSen1 Helicase Domain Exhibits 5′- to 3′-Helicase Activity with a Preference for Translocation on DNA Rather than RNA

(2015) Stephen Martin-Tumasz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR

(2015) Thomas C Roberts et al.   Nature Protocols

Transcription termination and the control of the transcriptome: why, where and how to stop

(2015) Odil Porrua et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress

(2014) Marco Saponaro et al.   CELL

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls

(2014) I. Felipe-Abrio et al.   EMBO JOURNAL

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

(2014) E. Herrera-Moyano et al.   GENES & DEVELOPMENT

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

(2014) Sibylle Schleich et al.   NATURE

Pervasive transcription: illuminating the dark matter of bacterial transcriptomes

(2014) Joseph T. Wade et al.   NATURE REVIEWS MICROBIOLOGY

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

(2014) D. Colak et al.   SCIENCE

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

(2014) Matthias Groh et al.   PLoS Genetics

Dealing with Pervasive Transcription

(2013) Torben Heick Jensen et al.   MOLECULAR CELL

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

(2012) Amaya Alzu et al.   CELL

Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats

(2012) Chia-Rung Liu et al.   CELL

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinetic Competition between RNA Polymerase II and Sen1-Dependent Transcription Termination

(2012) Dane Z. Hazelbaker et al.   MOLECULAR CELL

Replication Fork Reversal after Replication–Transcription Collision

(2012) Anne L. De Septenville et al.   PLoS Genetics

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

(2011) Dipak Dutta et al.   CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

SETX gene mutation in a family diagnosed autosomal dominant proximal spinal muscular atrophy

(2011) Sabine Rudnik-Schöneborn et al.   NEUROMUSCULAR DISORDERS

The Yeast 5′-3′ Exonuclease Rat1p Functions during Transcription Elongation by RNA Polymerase II

(2010) Silvia Jimeno-González et al.   MOLECULAR CELL

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Progression through the RNA Polymerase II CTD Cycle

(2009) Stephen Buratowski   MOLECULAR CELL