Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

(2021) Deyang Yu et al.   Cell Metabolism

BCAA Supplementation in Mice with Diet-Induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis

(2021) Jennifer Lee et al.   ENDOCRINOLOGY

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

(2020) Mario Ost et al.   EMBO REPORTS

3-Hydroxyisobutyrate, a Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism

(2020) Mona S. Nilsen et al.   DIABETES

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

(2020) Christopher A. Bishop et al.   FASEB JOURNAL

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

(2019) Robert W. McGarrah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review

(2018) Henver S. Brunetta et al.   AMINO ACIDS

Skeletal Muscle Tissue Trib3 Links Obesity with Insulin Resistance by Autophagic Degradation of AKT2

(2018) Minseo Kwon et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

(2017) Janin Henkel et al.   MOLECULAR MEDICINE

Combined Measurement of 6 Fat-Soluble Vitamins and 26 Water-Soluble Functional Vitamin Markers and Amino Acids in 50 μL of Serum or Plasma by High-Throughput Mass Spectrometry

(2016) Øivind Midttun et al.   ANALYTICAL CHEMISTRY

Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance

(2016) Wei Zhang et al.   DIABETES

Rapid quantification of underivatized amino acids in plasma by hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass-spectrometry

(2016) Hubertus C. M. T. Prinsen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity

(2016) Karolin Weitkunat et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

(2016) Luca A. Lotta et al.   PLOS MEDICINE

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy

(2016) Fuyang Zhang et al.   EBioMedicine

Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice

(2015) Karolin Weitkunat et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

(2013) W. Zhang et al.   DIABETES

Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels

(2013) Elke Binder et al.   PLoS One

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Ho-Jin Koh et al.   Nature Communications

Dietary l-leucine and l-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity

(2012) Anne Freudenberg et al.   AMINO ACIDS

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice

(2012) Anne Freudenberg et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

(2009) Jiarong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary Protein, Weight Loss, and Weight Maintenance

(2009) M.S. Westerterp-Plantenga et al.   Annual Review of Nutrition

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Muscular diacylglycerol metabolism and insulin resistance

(2008) Silvie Timmers et al.   PHYSIOLOGY & BEHAVIOR