Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation
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Title
Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation
Authors
Keywords
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Journal
ACS Synthetic Biology
Volume 11, Issue 4, Pages 1440-1453
Publisher
American Chemical Society (ACS)
Online
2022-03-23
DOI
10.1021/acssynbio.1c00236
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- (2019) Nirali N. Shah et al. Nature Reviews Clinical Oncology
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- Engineering mammalian cells for disease diagnosis and treatment
- (2018) Ana P Teixeira et al. CURRENT OPINION IN BIOTECHNOLOGY
- IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level
- (2017) Byron B. Au-Yeung et al. JOURNAL OF IMMUNOLOGY
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- (2017) Michel Sadelain et al. NATURE
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- (2017) Biliang Hu et al. Cell Reports
- Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy
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- Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma
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- TRUCKs: the fourth generation of CARs
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- A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
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- Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
- (2014) Paul F. Robbins et al. JOURNAL OF IMMUNOLOGY
- A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface
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