IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

(2016) Geoffrey A Smith et al.   Nature Chemical Biology

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

(2016) Susanne Heinzel et al.   NATURE IMMUNOLOGY

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

(2016) Kristen N Pollizzi et al.   NATURE IMMUNOLOGY

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

(2016) Karmel A Allison et al.   eLife

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

(2015) G. C. Preston et al.   EMBO JOURNAL

Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center

(2015) James Mueller et al.   JOURNAL OF IMMUNOLOGY

T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

(2015) Guillaume Voisinne et al.   Cell Reports

Small molecule inhibition of Csk alters affinity recognition by T cells

(2015) Boryana N Manz et al.   eLife

Plasticity in programming of effector and memory CD8+T-cell formation

(2015) Ramon Arens et al.   IMMUNOLOGICAL REVIEWS

Ikaros Imposes a Barrier to CD8+ T Cell Differentiation by Restricting Autocrine IL-2 Production

(2014) S. O'Brien et al.   JOURNAL OF IMMUNOLOGY

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

(2014) B. B. Au-Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

(2014) J. M. Marchingo et al.   SCIENCE

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

(2014) Karen E Tkach et al.   eLife

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Quorum sensing allows T cells to discriminate between self and nonself

(2013) T. C. Butler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR signaling requirements for activating T cells and for generating memory

(2012) Dietmar Zehn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

(2012) Julie Zikherman et al.   NATURE

Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

(2012) L. Pace et al.   SCIENCE

Interpretation of cellular proliferation data: Avoid the panglossian

(2011) Mario Roederer   CYTOMETRY PART A

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Primary Response Genes

(2011) Trent Fowler et al.   MOLECULAR CELL

A Role for the Immediate Early Gene Product c-fos in Imprinting T Cells with Short-Term Memory for Signal Summation

(2011) Carolyn E. Clark et al.   PLoS One