Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

(2021) Melissa A E van de Wal et al.   BRAIN

Disruption of mitochondrial complex I induces progressive parkinsonism

(2021) Patricia González-Rodríguez et al.   NATURE

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation

(2020) Raquel Perez-Gomez et al.   Scientific Reports

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

(2020) Eran Mick et al.   eLife

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

(2020) Tim L. Emmerzaal et al.   Translational Psychiatry

NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

(2020) Gregory S. McElroy et al.   Cell Metabolism

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

Towards the Monitoring of Functional Status in a Free-Living Environment for People with Hip or Knee Osteoarthritis: Design and Evaluation of the JOLO Blended Care App

(2020) Jill Emmerzaal et al.   SENSORS

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

(2019) Yuan-Shih Hu et al.   BRAIN

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

(2019) Sean R. Jesinkey et al.   Cell Reports

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

(2019) Misa Hirose et al.   Genes

Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation

(2019) Daniel Cabello-Rivera et al.   Frontiers in Neuroscience

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

(2018) Sathyaseelan S. Deepa et al.   AGING CELL

Partial loss of complex I due to NDUFS4 deficiency augments myocardial reperfusion damage by increasing mitochondrial superoxide/hydrogen peroxide production

(2018) Nidhi Kuksal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of mitochondria in stem cell fate and aging

(2018) Hongbo Zhang et al.   DEVELOPMENT

Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease

(2018) L Holper et al.   NEUROPSYCHOPHARMACOLOGY

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

(2018) Saul Soberanes et al.   Cell Metabolism

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

(2017) Ana L. Mora et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex

(2016) Zuzana Tatarkova et al.   NEUROCHEMICAL RESEARCH

Graded Maximal Exercise Testing to Assess Mouse Cardio-Metabolic Phenotypes

(2016) Jennifer M. Petrosino et al.   PLoS One

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Skeletal muscle mitochondria of NDUFS4−/− mice display normal maximal pyruvate oxidation and ATP production

(2015) Mohammad T. Alam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

(2015) Jialiang Yang et al.   Scientific Reports

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Complex-I-ty in aging

(2014) Jae H. Hur et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Gene expression changes with age in skin, adipose tissue, blood and brain

(2013) Daniel Glass et al.   GENOME BIOLOGY

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene

(2012) Dillon W. Leong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

(2012) R. Strong et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Mild Impairment of Mitochondrial Electron Transport Has Sex-Specific Effects on Lifespan and Aging in Mice

(2011) Bryan G. Hughes et al.   PLoS One

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster

(2010) Michael Rera et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

(2010) A. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

The structure of eukaryotic and prokaryotic complex I

(2009) T. Clason et al.   JOURNAL OF STRUCTURAL BIOLOGY

NDUFS4: Creation of a mouse model mimicking a Complex I disorder

(2009) Christopher A. Ingraham et al.   MITOCHONDRION

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons

(2009) Hae Young Lee et al.   Jove-Journal of Visualized Experiments

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY