Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

(2019) Michaela D. Filiou et al.   TRENDS IN NEUROSCIENCES

The future of rodent models in depression research

(2019) Anand Gururajan et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Etiology of Neuropsychiatric Disorders

(2018) Liming Pei et al.   BIOLOGICAL PSYCHIATRY

Biomarkers for mitochondrial energy metabolism diseases

(2018) Sara Boenzi et al.   Essays in Biochemistry

Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes

(2018) Kelly Doolin et al.   PSYCHONEUROENDOCRINOLOGY

Psychological Stress and Mitochondria

(2018) Martin Picard et al.   PSYCHOSOMATIC MEDICINE

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects

(2018) Ruin Moaddel et al.   PSYCHOPHARMACOLOGY

Metabolomics of Ndufs4−/− skeletal muscle: Adaptive mechanisms converge at the ubiquinone-cycle

(2018) Karin Terburgh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology

(2018) Emily L. Belleau et al.   BIOLOGICAL PSYCHIATRY

Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers

(2018) Jana Buzkova et al.   EMBO Molecular Medicine

Chronic Unpredictable Mild Stress for Modeling Depression in Rodents:Meta-analysis of Model Reliability

(2018) Svitlana Antoniuk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Revisiting mitochondrial diagnostic criteria in the new era of genomics

(2017) Peter Witters et al.   GENETICS IN MEDICINE

Metabolomics of mitochondrial disease

(2017) Karien Esterhuizen et al.   MITOCHONDRION

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

(2016) Joni Nikkanen et al.   Cell Metabolism

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum

(2016) M.I. Cordero et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Ndufs4 related Leigh syndrome: A case report and review of the literature

(2016) Juan Darío Ortigoza-Escobar et al.   MITOCHONDRION

Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling

(2016) Łukasz P Zieliński et al.   MITOCHONDRION

Skeletal muscle mitochondria of NDUFS4−/− mice display normal maximal pyruvate oxidation and ATP production

(2015) Mohammad T. Alam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α

(2015) Felix Distelmaier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

(2015) Mario Ost et al.   FASEB JOURNAL

Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression

(2015) Edana Cassol et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia

(2015) Ganesh R. Manjeri et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial Diseases Part I: Mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors

(2015) Alessandra Torraco et al.   MITOCHONDRION

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Combined Metabolomics and Proteomics Analysis of Major Depression in an Animal Model: Perturbed Energy Metabolism in the Chronic Mild Stressed Rat Cerebellum

(2015) Wei-hua Shao et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

(2015) Martin Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial function in the brain links anxiety with social subordination

(2015) Fiona Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult neurogenesis: a substrate for experience-dependent change

(2015) Maya Opendak et al.   TRENDS IN COGNITIVE SCIENCES

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

(2015) Alan Pehrson et al.   Drug Design Development and Therapy

A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

(2015) Julie Thompson Legault et al.   Cell Reports

Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression

(2015) A Karabatsiakis et al.   Translational Psychiatry

Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments

(2013) Gregory Oxenkrug   CURRENT DRUG TARGETS

Mitochondrial respiration in blood platelets of depressive patients

(2013) Jana Hroudová et al.   MITOCHONDRION

Endocrine disorders in mitochondrial disease

(2013) Andrew M. Schaefer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondria and the economy of stress (mal)adaptation

(2013) Éva Morava et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?

(2012) Rai Khalid Farooq et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolic consequences of NDUFS4 gene deletion in immortalized mouse embryonic fibroblasts

(2012) Federica Valsecchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases

(2012) S. Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Neurobiology of resilience

(2012) Scott J Russo et al.   NATURE NEUROSCIENCE

Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine

(2011) S. Harvey Mudd et al.   MOLECULAR GENETICS AND METABOLISM

Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency

(2010) Saskia Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability

(2010) K. Mozhui et al.   JOURNAL OF NEUROSCIENCE

Depressive behaviour in children diagnosed with a mitochondrial disorder

(2010) E. Morava et al.   MITOCHONDRION

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

Oxidative stress in anxiety and comorbid disorders

(2010) Iiris Hovatta et al.   NEUROSCIENCE RESEARCH

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry

(2010) Zhen-Yu Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

The neuro-symphony of stress

(2009) Marian Joëls et al.   NATURE REVIEWS NEUROSCIENCE

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains

(2008) X. Yu et al.   GENOME RESEARCH

Major depression in adolescent children consecutively diagnosed with mitochondrial disorder

(2008) S. Koene et al.   JOURNAL OF AFFECTIVE DISORDERS

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

(2008) Gislaine T. Rezin et al.   NEUROCHEMISTRY INTERNATIONAL

Brain inflammation and adult neurogenesis: The dual role of microglia

(2008) C.T. Ekdahl et al.   NEUROSCIENCE

Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice

(2008) Oguz Mutlu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mice selected for high versus low stress reactivity: A new animal model for affective disorders

(2008) Chadi Touma et al.   PSYCHONEUROENDOCRINOLOGY