Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers

Intermittent fasting: from calories to time restriction

(2021) Eleonora Duregon et al.   GeroScience

Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity

(2021) Stavroula Argyridou et al.   JOURNAL OF NUTRITION

Association of Red Meat and Poultry Consumption With the Risk of Metabolic Syndrome: A Meta-Analysis of Prospective Cohort Studies

(2021) Hongbin Guo et al.   Frontiers in Nutrition

Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

(2021) Claudio Vernieri et al.   Cancer Discovery

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

(2020) James L. Dorling et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis

(2020) Yarong Liu et al.   MEDIATORS OF INFLAMMATION

Meat and fish intake and type 2 diabetes: Dose–response meta-analysis of prospective cohort studies

(2020) Xiu Yang et al.   DIABETES & METABOLISM

Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition

(2020) Françoise Wilhelmi de Toledo et al.   ANNALS OF MEDICINE

Fasting Therapy Contributes to the Improvement of Endothelial Function and Decline in Vascular Injury-Related Markers in Overweight and Obese Individuals via Activating Autophagy of Endothelial Progenitor Cells

(2020) Jiapan Sun et al.   Evidence-based Complementary and Alternative Medicine

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

(2020) Janis Kuka et al.   Scientific Reports

The correlation between plasma trimethylamine N-oxide level and heart failure classification in northern Chinese patients

(2020) Zengxiang Dong et al.   Annals of Palliative Medicine

Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease

(2020) Annunziata Nancy Crupi et al.   Current Diabetes Reports

Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults

(2019) Melissa Erickson et al.   Nutrients

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

(2019) Priya Rangan et al.   Cell Reports

Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial

(2019) Rachel Washburn et al.   Nutrients

Modulation of Circulating Trimethylamine N-Oxide Concentrations by Dietary Supplements and Pharmacological Agents: A Systematic Review

(2019) Nora A Kalagi et al.   Advances in Nutrition

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

(2018) Jin Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Red meat intake in chronic kidney disease patients: Two sides of the coin

(2018) Denise Mafra et al.   NUTRITION

Meat Consumption and Risk of Metabolic Syndrome: Results from the Korean Population and a Meta-Analysis of Observational Studies

(2018) Youngyo Kim et al.   Nutrients

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

(2018) Zeneng Wang et al.   EUROPEAN HEART JOURNAL

Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice

(2018) Wei-Kai Wu et al.   GUT

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

(2018) Robert A. Koeth et al.   JOURNAL OF CLINICAL INVESTIGATION

Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice

(2018) Siying Wei et al.   Nutrition & Metabolism

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects

(2017) Pablo Hernández-Alonso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fruit and vegetable consumption and risk of the metabolic syndrome: a meta-analysis

(2017) Yue Tian et al.   PUBLIC HEALTH NUTRITION

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

(2017) Kui Chen et al.   Frontiers in Physiology

Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

(2017) Mohammed Al-Obaide et al.   Journal of Clinical Medicine

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Fruit and vegetable intake and risk of incident of type 2 diabetes: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

(2016) L Mamluk et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Determination of trimethylamine-N-oxide in combination withl-carnitine andγ-butyrobetaine in human plasma by UPLC/MS/MS

(2015) Solveiga Grinberga et al.   BIOMEDICAL CHROMATOGRAPHY

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Weight regaining: From statistics and behaviors to physiology and metabolism

(2015) Costas A. Anastasiou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet

(2015) Nabil E. Boutagy et al.   Obesity

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children

(2015) Chenhong Zhang et al.   EBioMedicine

Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats

(2014) Marcin Ufnal et al.   CANADIAN JOURNAL OF CARDIOLOGY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study

(2014) Michael Lever et al.   PLoS One

Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis

(2013) Maija Dambrova et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes

(2010) Leanne M. Redman et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Dietary Adherence with or without Exercise on Weight Loss: A Mechanistic Approach to a Global Problem

(2009) Pedro Del Corral et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe