Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study

Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking

(2021) Xianhai Li et al.   Frontiers in Cell and Developmental Biology

Active ingredients from Chinese medicine plants as therapeutic strategies for asthma: Overview and challenges

(2021) Wenqian Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

The basic immunology of asthma

(2021) Hamida Hammad et al.   CELL

Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials

(2021) Rishab Marahatha et al.   PHYTOTHERAPY RESEARCH

The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats

(2021) Hong Zhao et al.   NEUROLOGICAL RESEARCH

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui-Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

(2020) Chun Li et al.   Evidence-based Complementary and Alternative Medicine

P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells

(2020) Simon Lea et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma: results from two phase 3, randomised, double-blind, placebo-controlled trials

(2020) Jonathan A Bernstein et al.   Lancet Respiratory Medicine

Biologics for oral corticosteroid-dependent asthma

(2020) İnsu Yılmaz   ALLERGY AND ASTHMA PROCEEDINGS

Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation

(2020) Fan Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function

(2020) Fan Wu et al.   PHYTOMEDICINE

Traditional Chinese medicine use may reduce medical utility in patients with asthma: a nationwide population-based retrospective cohort study

(2020) P F Liao et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Adult-onset Still’s disease successfully treated with Chinese herbal medicine: A case report with 15-month follow-up

(2020) Ming-sheng Lyu et al.   Journal of Integrative Medicine-JIM

The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation

(2020) Miroslava Molitorisova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

(2020) Stephen K Burley et al.   NUCLEIC ACIDS RESEARCH

Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells

(2020) Hideki Inoue et al.   Journal of Clinical Medicine

A comprehensive application: Molecular docking and network pharmacology for the prediction of bioactive constituents and elucidation of mechanisms of action in component-based Chinese medicine

(2020) Xinyi Jiao et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia

(2019) Alejandro A. Pezzulo et al.   JOURNAL OF CLINICAL INVESTIGATION

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

(2019) Runzhi Zhang et al.   Frontiers in Pharmacology

Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice

(2019) Xueping Yang et al.   BMC Complementary and Alternative Medicine

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

(2019) Denitsa Dimitrova et al.   RESPIRATORY MEDICINE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management

(2019) Eugene R Bleecker et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Combined allergic rhinitis and asthma syndrome (CARAS)

(2019) Laércia K.D. Paiva Ferreira et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of IL-17 in asthma pathogenesis and its implications for the clinic

(2019) Rakhee K Ramakrishnan et al.   Expert Review of Respiratory Medicine

A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

(2019) Hande Gül Ulusoy et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics

(2019) Yunxia Wang et al.   NUCLEIC ACIDS RESEARCH

The DisGeNET knowledge platform for disease genomics: 2019 update

(2019) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Integrating Network Pharmacology and Pharmacological Evaluation for Deciphering the Action Mechanism of Herbal Formula Zuojin Pill in Suppressing Hepatocellular Carcinoma

(2019) Wei Guo et al.   Frontiers in Pharmacology

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

(2018) Christos Rossios et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Consequences of long-term OCS therapy and its side effects in severe asthma in adults – A focused review of the impact data in the literature

(2018) Timm Volmer et al.   EUROPEAN RESPIRATORY JOURNAL

Oral corticosteroid-dependent asthma

(2018) Ian D. Pavord   CURRENT OPINION IN PULMONARY MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Identification of IL-17F/frequent exacerbator endotype in asthma

(2017) Fabio L.M. Ricciardolo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis

(2017) Yuanqi Liu et al.   LIFE SCIENCES

Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae

(2017) Lijin Duan et al.   Microbial Cell Factories

Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model

(2017) Ahmed Z. El-Hashim et al.   Scientific Reports

Identifying a biomarker network for corticosteroid resistance in asthma from bronchoalveolar lavage samples

(2016) José Eduardo Vargas et al.   MOLECULAR BIOLOGY REPORTS

Quercetin and Its Anti-Allergic Immune Response

(2016) Jiri Mlcek et al.   MOLECULES

Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

(2016) Guohua Yu et al.   International Journal of Chronic Obstructive Pulmonary Disease

BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine

(2016) Zhongyang Liu et al.   Scientific Reports

Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy

(2015) Julie Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oxidants Induce a Corticosteroid-Insensitive Phosphorylation of Histone 3 at Serine 10 in Monocytes

(2015) John A. Marwick et al.   PLoS One

Activated p38 MAPK in Peripheral Blood Monocytes of Steroid Resistant Asthmatics

(2015) Ling-bo Li et al.   PLoS One

IL-17 in Severe Asthma. Where Do We Stand?

(2014) Julie Chesné et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

jvenn: an interactive Venn diagram viewer

(2014) Philippe Bardou et al.   BMC BIOINFORMATICS

Interleukin-17 cytokine signalling in patients with asthma

(2014) A. Linden et al.   EUROPEAN RESPIRATORY JOURNAL

Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90

(2014) Ming-Yung Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways

(2012) Samuel K. Shimp et al.   INFLAMMATION RESEARCH

Neutrophilic Inflammation in Severe Asthma

(2012) Kazuyuki Nakagome et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle

(2011) Lan Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

(2011) Kian Fan Chung   CHEST

Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma

(2010) Shailaja G. Mahajan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HIT: linking herbal active ingredients to targets

(2010) H. Ye et al.   NUCLEIC ACIDS RESEARCH

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry

(2010) L. G. Heaney et al.   THORAX

Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma

(2009) P. Bhavsar et al.   EUROPEAN RESPIRATORY JOURNAL

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX