RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
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Title
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
Authors
Keywords
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Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-05-19
DOI
10.1038/s41467-022-30489-z
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Related references
Note: Only part of the references are listed.- Alternative RNA splicing in tumour heterogeneity, plasticity and therapy
- (2022) Sebastian Öther-Gee Pohl et al. Disease Models & Mechanisms
- Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease
- (2021) Rebecca E. Wagner et al. BIOESSAYS
- RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
- (2021) Victoria Gudiño et al. Nature Communications
- Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function
- (2021) Fiona Haward et al. eLife
- Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis
- (2021) Victoria Gudiño et al. Cell Death & Disease
- Roles and mechanisms of alternative splicing in cancer — implications for care
- (2020) Sophie C. Bonnal et al. Nature Reviews Clinical Oncology
- Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
- (2019) Andrew Woolston et al. CANCER CELL
- Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
- (2019) Rene Jackstadt et al. CANCER CELL
- The biology and role of CD44 in cancer progression: therapeutic implications
- (2018) Chen Chen et al. Journal of Hematology & Oncology
- Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
- (2018) Georgios Vlachogiannis et al. SCIENCE
- Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
- (2018) J. Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
- (2018) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
- (2017) Felipe de Sousa e Melo et al. NATURE
- Visualization and targeting of LGR5+ human colon cancer stem cells
- (2017) Mariko Shimokawa et al. NATURE
- A single-cell survey of the small intestinal epithelium
- (2017) Adam L. Haber et al. NATURE
- Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood
- (2017) Julia Joung et al. NATURE
- In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
- (2017) Jatin Roper et al. NATURE BIOTECHNOLOGY
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- QuPath: Open source software for digital pathology image analysis
- (2017) Peter Bankhead et al. Scientific Reports
- Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
- (2016) Paul W. Tetteh et al. Cell Stem Cell
- Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice
- (2016) J Santo et al. INTERNATIONAL JOURNAL OF OBESITY
- An improved smaller biotin ligase for BioID proximity labeling
- (2016) Dae In Kim et al. MOLECULAR BIOLOGY OF THE CELL
- The Perseus computational platform for comprehensive analysis of (prote)omics data
- (2016) Stefka Tyanova et al. NATURE METHODS
- Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ
- (2016) Srisathiyanarayanan Dharmaiah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparison of liver oncogenic potential among human RAS isoforms
- (2016) Sook In Chung et al. Oncotarget
- Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
- (2015) Lukas E. Dow et al. CELL
- SRSF1-Regulated Alternative Splicing in Breast Cancer
- (2015) Olga Anczuków et al. MOLECULAR CELL
- The spliceosome is a therapeutic vulnerability in MYC-driven cancer
- (2015) Tiffany Y.-T. Hsu et al. NATURE
- MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
- (2015) Cheryl M. Koh et al. NATURE
- TCGASpliceSeq a compendium of alternative mRNA splicing in cancer
- (2015) Michael Ryan et al. NUCLEIC ACIDS RESEARCH
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt high Metastatic Colon Cancer Cells
- (2014) Simone Ragusa et al. Cell Reports
- ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
- (2013) Kevin B. Myant et al. Cell Stem Cell
- SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis
- (2013) Yu Fu et al. EMBO Molecular Medicine
- A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
- (2013) D. S. Hong et al. INVESTIGATIONAL NEW DRUGS
- Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
- (2013) Gunther Zimmermann et al. NATURE
- Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes
- (2013) N. P. Hoyle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition
- (2013) A. Clery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
- (2013) Daehwan Kim et al. GENOME BIOLOGY
- Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors
- (2012) Sarah Schwitalla et al. CANCER CELL
- Transcriptional Amplification in Tumor Cells with Elevated c-Myc
- (2012) Charles Y. Lin et al. CELL
- Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
- (2012) Sarah Schwitalla et al. CELL
- Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
- (2012) Johan H. van Es et al. NATURE CELL BIOLOGY
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma
- (2012) Emil Lou et al. PLoS One
- Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer
- (2012) A. Kreso et al. SCIENCE
- Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
- (2012) Shipra Das et al. Cell Reports
- The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
- (2011) Anna Merlos-Suárez et al. Cell Stem Cell
- A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
- (2011) Hua Tian et al. NATURE
- Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged
- (2010) C. J. David et al. GENES & DEVELOPMENT
- Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway
- (2010) Kasper Thorsen et al. MOLECULAR & CELLULAR PROTEOMICS
- Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
- (2010) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- K-rasexon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation
- (2009) Feijun Luo et al. JOURNAL OF PATHOLOGY
- Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype
- (2008) Tatiana V. Petrova et al. CANCER CELL
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