Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
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Title
Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
Authors
Keywords
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Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-04-19
DOI
10.1038/s41467-022-29517-9
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Note: Only part of the references are listed.- Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
- (2021) Carl M. Gay et al. CANCER CELL
- Cancer-associated fibroblasts: overview, progress, challenges, and directions
- (2021) Qinrong Ping et al. CANCER GENE THERAPY
- Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
- (2021) Ling Cai et al. Communications Biology
- Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
- (2021) Anish Thomas et al. CANCER CELL
- Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
- (2021) Nitin Roper et al. Nature Communications
- Targeting DNA repair to drive immune responses: it's time to reconsider the strategy for clinical translation
- (2020) Nobuyuki Takahashi et al. CLINICAL CANCER RESEARCH
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
- (2020) Abbie S. Ireland et al. CANCER CELL
- Harnessing natural killer immunity in metastatic small cell lung cancer
- (2020) Sarah A. Best et al. Journal of Thoracic Oncology
- Lineage plasticity in cancer: a shared pathway of therapeutic resistance
- (2020) Álvaro Quintanal-Villalonga et al. Nature Reviews Clinical Oncology
- Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
- (2020) Nemanja Despot Marjanovic et al. CANCER CELL
- The Effect of Advances in Lung-Cancer Treatment on Population Mortality
- (2020) Nadia Howlader et al. NEW ENGLAND JOURNAL OF MEDICINE
- A pan-cancer analysis of the frequency of DNA alterations across cell cycle activity levels
- (2020) Arian Lundberg et al. ONCOGENE
- Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization
- (2020) Marina K. Baine et al. Journal of Thoracic Oncology
- SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures
- (2020) Camille Tlemsani et al. Cell Reports
- Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
- (2020) Fang Huang et al. JOURNAL OF CLINICAL INVESTIGATION
- YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell–Inflamed Phenotype
- (2020) Taofeek K. Owonikoko et al. Journal of Thoracic Oncology
- Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay
- (2019) Chao Zhong et al. DEVELOPMENTAL BIOLOGY
- Durvalumab in Combination with Olaparib in Patients with Relapsed Small Cell Lung Cancer: Results from a Phase II Study
- (2019) Anish Thomas et al. Journal of Thoracic Oncology
- Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies
- (2019) Junko Murai et al. PHARMACOLOGY & THERAPEUTICS
- Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies
- (2019) Nikolas G. Balanis et al. CANCER CELL
- MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion
- (2019) Milind D. Chalishazar et al. CLINICAL CANCER RESEARCH
- Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
- (2019) Ela Elyada et al. Cancer Discovery
- Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer
- (2019) Franziska Böttger et al. Cell Reports
- Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer
- (2019) Anna F. Farago et al. Cancer Discovery
- Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses
- (2019) Taofeek K. Owonikoko et al. Journal of Thoracic Oncology
- MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
- (2019) Marcel A. Dammert et al. Nature Communications
- An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma
- (2019) Balazs Acs et al. Nature Communications
- Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
- (2019) David J. Wooten et al. PLoS Computational Biology
- Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction
- (2019) Shixiang Wang et al. eLife
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
- (2018) Fang Huang et al. Cell Metabolism
- The prognostic analysis of different metastatic patterns in extensive-stage small-cell lung cancer patients: a large population-based study
- (2018) Hongchao Cai et al. Future Oncology
- POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
- (2018) Yu-Han Huang et al. GENES & DEVELOPMENT
- Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors
- (2018) Anish Thomas et al. JOURNAL OF CLINICAL ONCOLOGY
- Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
- (2018) Benjamin J. Drapkin et al. Cancer Discovery
- Characteristics and Outcomes of Small Cell Lung Cancer Detected by CT Screening
- (2018) Anish Thomas et al. CHEST
- First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer
- (2018) Leora Horn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
- (2018) Alex H. Wagner et al. Nature Communications
- Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032
- (2018) Neal Ready et al. Journal of Thoracic Oncology
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
- (2017) Mark Ayers et al. JOURNAL OF CLINICAL INVESTIGATION
- Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
- (2017) Jing Shan Lim et al. NATURE
- Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
- (2017) Karen McColl et al. Oncotarget
- Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies
- (2017) Robert J. Cardnell et al. Oncotarget
- QuPath: Open source software for digital pathology image analysis
- (2017) Peter Bankhead et al. Scientific Reports
- Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression
- (2016) Eric Polley et al. JNCI-Journal of the National Cancer Institute
- TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation
- (2016) Dafni-Eleftheria Pefani et al. MOLECULAR CELL
- Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
- (2016) Himisha Beltran et al. NATURE MEDICINE
- Prognostic effect of liver metastasis in lung cancer patients with distant metastasis
- (2016) Yijiu Ren et al. Oncotarget
- ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs
- (2016) Mark D. Borromeo et al. Cell Reports
- Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression
- (2016) Eric Polley et al. JNCI-Journal of the National Cancer Institute
- Comprehensive genomic profiles of small cell lung cancer
- (2015) Julie George et al. NATURE
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis inMob1a/1b-deficient mice
- (2015) Miki Nishio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway
- (2015) Fumihiko Murai et al. Cell Discovery
- Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor
- (2014) Camilla L. Christensen et al. CANCER CELL
- ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
- (2014) A. Augustyn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
- (2014) M. Hidalgo et al. Cancer Discovery
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
- (2013) Gabriela Bindea et al. IMMUNITY
- Specific organ metastases and survival in small cell lung cancer
- (2012) KENSUKE NAKAZAWA et al. Oncology Letters
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo
- (2011) Dimitris Anastassiou et al. BMC CANCER
- Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study
- (2011) Jack Cuzick et al. LANCET ONCOLOGY
- Survival outcomes with the use of surgery in limited-stage small cell lung cancer
- (2010) David Schreiber et al. CANCER
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- TGF-β-induced epithelial to mesenchymal transition
- (2009) Jian Xu et al. CELL RESEARCH
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