Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis inMob1a/1b-deficient mice

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver

(2014) Sayaka Sekiya et al.   AMERICAN JOURNAL OF PATHOLOGY

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer

(2014) A. Melotti et al.   EMBO Molecular Medicine

Osteopontin induces ductular reaction contributing to liver fibrosis

(2014) Xiaodong Wang et al.   GUT

Hippo-YAP signaling pathway: A new paradigm for cancer therapy

(2014) Yanlei Ma et al.   INTERNATIONAL JOURNAL OF CANCER

Capturing the mammalian Hippo: Elucidating its role in cancer

(2013) Miki Nishio et al.   CANCER SCIENCE

CCAAT/enhancer binding protein-mediated regulation of TGF  receptor 2 expression determines the hepatoblast fate decision

(2013) K. Takayama et al.   DEVELOPMENT

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis

(2013) C. Yi et al.   Science Signaling

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

(2013) Luca Lignitto et al.   Nature Communications

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Recovery of Mature Hepatocytic Phenotype following Bile Ductular Transdifferentiation of Rat Hepatocytes in Vitro

(2012) Masayuki Sone et al.   AMERICAN JOURNAL OF PATHOLOGY

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

Proof-of-Principle of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: Final Results of a Study in Mali and Senegal

(2012) Mamadou O. Traore et al.   PLoS Neglected Tropical Diseases

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

(2011) H. Murakami et al.   CANCER RESEARCH

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

MOB control: Reviewing a conserved family of kinase regulators

(2011) Alexander Hergovich   CELLULAR SIGNALLING

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

(2010) S. Sharmeen et al.   BLOOD

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Cell shape and TGF-β signaling define the choice of lineage during in vitro differentiation of mouse primary hepatic precursors

(2010) Leila Akkari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

The hepatic stem cell niche: Identification by label-retaining cell assay

(2008) Reiichiro Kuwahara et al.   HEPATOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1

(2008) S Hirabayashi et al.   ONCOGENE