Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy

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(2017) Paul S. Buckmaster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

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(2014) Imad M. Najm et al.   ACTA NEUROPATHOLOGICA

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