PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation

Immune Consequences of Endothelial Cells’ Activation and Dysfunction During Sepsis

(2020) Stéphanie Pons et al.   CRITICAL CARE CLINICS

Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation

(2020) Frederic Lagarrigue et al.   BLOOD

Mechanics of the cellular actin cortex: From signalling to shape change

(2020) Manasi Kelkar et al.   CURRENT OPINION IN CELL BIOLOGY

The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering

(2020) Sampo Kukkurainen et al.   JOURNAL OF CELL SCIENCE

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

(2019) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Cell Adhesion by Integrins

(2019) Michael Bachmann et al.   PHYSIOLOGICAL REVIEWS

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

RAP GTPases and platelet integrin signaling

(2018) Lucia Stefanini et al.   PLATELETS

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Macrophage PI3K  Drives Pancreatic Ductal Adenocarcinoma Progression

(2016) M. M. Kaneda et al.   Cancer Discovery

Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration

(2013) Fabeha Fazal et al.   PLoS One

PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

(2013) Michael C. Schmid et al.   PLoS One

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

Combined Blockade of Integrin- 4 1 Plus Cytokines SDF-1  or IL-1  Potently Inhibits Tumor Inflammation and Growth

(2011) M. C. Schmid et al.   CANCER RESEARCH

Association between  4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migration

(2011) L. A. R. Rosado et al.   JOURNAL OF CELL SCIENCE

Non–Muscle Myosin Light Chain Kinase Isoform Is a Viable Molecular Target in Acute Inflammatory Lung Injury

(2010) Tamara Mirzapoiazova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates  4 integrins

(2008) Y. Imai et al.   BLOOD

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1 Activation in Collagen Phagocytosis Is Dependent on Nonmuscle Myosin II-A

(2008) Pamela D. Arora et al.   MOLECULAR BIOLOGY OF THE CELL

Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins

(2008) Jingsong Xu et al.   NATURE IMMUNOLOGY