PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

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Clinical effects of natalizumab on multiple sclerosis appear early in treatment course

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Update on PML and PML-IRIS Occurring in Multiple Sclerosis Patients Treated With Natalizumab

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Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

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Combined Blockade of Integrin- 4 1 Plus Cytokines SDF-1  or IL-1  Potently Inhibits Tumor Inflammation and Growth

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Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth

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Immunity, Inflammation, and Cancer

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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The final steps of integrin activation: the end game

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Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance

(2010) Kiyoko Fukami et al.   PROGRESS IN LIPID RESEARCH

Control of cell adhesion dynamics by Rap1 signaling

(2009) Benjamin Boettner et al.   CURRENT OPINION IN CELL BIOLOGY

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

PKC-  selectively controls the adhesion-stimulating molecule Rap1

(2008) T. Letschka et al.   BLOOD

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1a Is a Key Regulator of Fibroblast Growth Factor 2-Induced Angiogenesis and Together with Rap1b Controls Human Endothelial Cell Functions

(2008) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols