Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood

Ex Vivo Perfusion and In Vivo Xenotransplantation of Pig Lungs with Humanized Von Willebrand Factor Demonstrate Reduced Platelet Sequestration

(2021) M.R. Connolly et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Pig‐to‐baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments

(2021) Lars Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation

(2020) Alfred Joseph Tector et al.   Frontiers in Immunology

P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

(2018) Christopher T. Laird et al.   XENOTRANSPLANTATION

GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

(2018) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Progress and challenges in Lung xenotransplantation

(2018) Lars Burdorf et al.   Current Opinion in Organ Transplantation

Advances in liver xenotransplantation

(2018) Arielle Cimeno et al.   Current Opinion in Organ Transplantation

E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model

(2017) Dorian Culmer et al.   THROMBOSIS AND HAEMOSTASIS

Role of human CD200 overexpression in pig-to-human xenogeneic immune response compared with human CD47 overexpression

(2017) Ji-Jing Yan et al.   TRANSPLANTATION

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages

(2017) Sung Han Jung et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in MiceHighlights

(2016) Roman Covarrubias et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor

(2016) Lars Burdorf et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Current status of pig lung xenotransplantation

(2015) Natalia Kubicki et al.   International Journal of Surgery

Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury

(2014) L. Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Activated Protein C Decreases Thrombosis onPorcine Endothelium Transgenic for Human Endothelial Protein C Receptor - A Novel Mechanism to Decrease Porcine Xenograft Injury.

(2014) D.G. Harris et al.   JOURNAL OF SURGICAL RESEARCH

Increased transfusion-free survival following auxiliary pig liver xenotransplantation

(2014) Heidi Yeh et al.   XENOTRANSPLANTATION

Corneal blindness and xenotransplantation

(2014) Vladimir Lamm et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

(2014) Mee Kum Kim et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation

(2013) Glen P. Westall et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Kidney xenotransplantation

(2013) Peter J. Cowan et al.   KIDNEY INTERNATIONAL

Pro- and anti-inflammatory effects of histamine on tissue factor and TNFα expression in monocytes of human blood

(2013) Bjarne Østerud et al.   THROMBOSIS RESEARCH

Cardiac xenotransplantation

(2012) Guerard W. Byrne et al.   Current Opinion in Organ Transplantation

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

(2012) David K. C. Cooper et al.   XENOTRANSPLANTATION

Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons

(2012) Karen Kim et al.   XENOTRANSPLANTATION

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

CD47: a new player in phagocytosis and xenograft rejection

(2011) Nalu Navarro-Alvarez et al.   Cellular & Molecular Immunology

Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1

(2011) Chiguang Feng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection

(2011) Bao-Ngoc H. Nguyen et al.   XENOTRANSPLANTATION

Pig-to-nonhuman primate islet xenotransplantation

(2009) Bernhard J. Hering et al.   TRANSPLANT IMMUNOLOGY

Rejection of Cardiac Xenografts Transplanted from α1,3-Galactosyltransferase Gene-Knockout (GalT-KO) Pigs to Baboons

(2008) Y. Hisashi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation

(2008) Young Tae Kim et al.   XENOTRANSPLANTATION

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION