Pig‐to‐baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

(2019) S C Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IS IL‐6 Receptor blockade (Tocilizumab) beneficial or detrimental to pig‐to‐baboon organ Xenotransplantation?

(2019) Guoqiang Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates

(2018) Liaoran Wang et al.   TRANSPLANTATION

Porcine IL-6, IL-1β, and TNF-α regulate the expression of pro-inflammatory-related genes and tissue factor in human umbilical vein endothelial cells

(2018) Hanchao Gao et al.   XENOTRANSPLANTATION

P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

(2018) Christopher T. Laird et al.   XENOTRANSPLANTATION

GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

(2018) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Progress and challenges in Lung xenotransplantation

(2018) Lars Burdorf et al.   Current Opinion in Organ Transplantation

Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood

(2018) Lars Burdorf et al.   XENOTRANSPLANTATION

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

Therapeutic regulation of systemic inflammation in xenograft recipients

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages

(2017) Sung Han Jung et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor

(2016) Lars Burdorf et al.   XENOTRANSPLANTATION

Porcine Extrahepatic Vascular Endothelial Asialoglycoprotein Receptor 1 Mediates Xenogeneic Platelet Phagocytosis In Vitro and in Human-to-Pig Ex Vivo Xenoperfusion

(2015) Anjan K. Bongoni et al.   TRANSPLANTATION

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR)

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

(2015) Peter J. Cowan et al.   International Journal of Surgery

Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury

(2014) L. Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic Human Thrombomodulin Expression Reduces Xenogeneic Thrombosis: a Promising Means of Reducing Pig Lung Xenograft Thrombotic Injury

(2014) D.G. Harris et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Systemic inflammation in xenograft recipients precedes activation of coagulation

(2014) Mohamed B. Ezzelarab et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Thrombin Generation and Platelet Activation in a Xenogenic Lung Perfusion Model Determine Survival of GalTKO.hCD46 Lungs

(2013) L. Burdorf et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

(2013) Annegret Wuensch et al.   TRANSPLANTATION

Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells

(2013) Mohamed B. Ezzelarab et al.   XENOTRANSPLANTATION

Porcine Sialoadhesin: A Newly Identified Xenogeneic Innate Immune Receptor

(2012) L. G. Brock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47

(2011) Chunfeng Wang et al.   CELL TRANSPLANTATION

Primary Porcine Kupffer Cell Phagocytosis of Human Platelets Involves the CD18 Receptor

(2011) Ray K. Chihara et al.   TRANSPLANTATION

Immunoregulation Effect by Overexpression of Heme Oxygenase-1 on Cardiac Xenotransplantation

(2011) Z. Shen et al.   TRANSPLANTATION PROCEEDINGS

Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection

(2011) Bao-Ngoc H. Nguyen et al.   XENOTRANSPLANTATION

Current status of xenotransplantation and prospects for clinical application

(2009) Richard N. Pierson et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons

(2008) Akira Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Coagulation dysregulation as a barrier to xenotransplantation in the primate

(2008) Chih Che Lin et al.   TRANSPLANT IMMUNOLOGY