Lipoxygenases in chronic liver diseases: current insights and future perspectives

G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment

(2021) Ming Yang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

(2021) Shiyun Pu et al.   Frontiers in Pharmacology

Metabolomics and Lipidomics: Expanding the Molecular Landscape of Exercise Biology

(2021) Mehdi R. Belhaj et al.   Metabolites

Astragaloside IV Alleviates Liver Inflammation, Oxidative Stress and Apoptosis to Protect Against Experimental Non-Alcoholic Fatty Liver Disease

(2021) Xiao-yu Liang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

New clinical and pathophysiological perspectives defining the trajectory of cirrhosis

(2021) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Ferroptosis in liver disease: new insights into disease mechanisms

(2021) Jing Wu et al.   Cell Death Discovery

5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease

(2020) Marcin Banaszczak et al.   Medicina-Lithuania

Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver

(2020) Ya-ru Xue et al.   ACTA PHARMACOLOGICA SINICA

Nonalcoholic Fatty Liver Disease Risk Factors Affect Liver-Related Outcomes After Direct-Acting Antiviral Treatment for Hepatitis C

(2020) Jihane N. Benhammou et al.   DIGESTIVE DISEASES AND SCIENCES

Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice

(2020) Yoshiko Mori et al.   JOURNAL OF BIOCHEMISTRY

The enzymology of human eicosanoid pathways: the lipoxygenase branches

(2020) Roger Gregory Biringer   MOLECULAR BIOLOGY REPORTS

Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis

(2020) Alexander Queck et al.   Frontiers in Immunology

Puerarin Exerts the Hepatoprotection from Chronic Alcohol-Induced Liver Injury via Inhibiting the Cyclooxygenase-2 and the 5-Lipoxygenase Pathway in Rats

(2020) Lugao Tian et al.   Complementary Medicine Research

Changing Trends in Liver Transplantation

(2020) Tommy Ivanics et al.   TRANSPLANTATION

Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway

(2020) Yaru Xue et al.   Scientific Reports

Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis

(2019) Zhu Zhan et al.   PeerJ

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukocytes from obese individuals exhibit an impaired SPM signature

(2019) Cristina López-Vicario et al.   FASEB JOURNAL

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

(2019) Shiyun Pu et al.   Frontiers in Pharmacology

Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death

(2019) Qian-Yi Sun et al.   Oxidative Medicine and Cellular Longevity

Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis

(2018) Zehra Tuğçe Gür et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

The anti-fibrotic agent, tipelukast (MN-001) reduces serum triglyceride significantly in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients with hypertriglyceridemia after 4 weeks of treatment, an interim analysis of ongoing clinical trial, MN-001-NATG-201

(2018) K. Matsuda et al.   JOURNAL OF HEPATOLOGY

Herbal tea consumption and the liver – All is not what it seems!

(2018) Cyriac Abby Philips et al.   JOURNAL OF HEPATOLOGY

Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression

(2018) Tae Woo Jung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic liver disease: scavenger hunt for novel therapies

(2018) Daniel A Patten et al.   LANCET

Lipoxin A 4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis

(2018) Fen Xu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Specialized Proresolving Mediators: Enhancing Nonalcoholic Steatohepatitis and Fibrosis Resolution

(2018) Giovanni Musso et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase

(2018) Shweta Sinha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease

(2018) Josephine Skat-Rørdam et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Selective toxicity of caffeic acid in hepatocellular carcinoma cells

(2018) David L. Brautigan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease

(2018) Cyrielle Caussy et al.   GUT

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review

(2018) Undurti N. Das   Journal of Advanced Research

BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system

(2018) Qiong-Feng Chen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

(2017) Zoe Hall et al.   HEPATOLOGY

Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study

(2017) Louise J.M. Alferink et al.   JOURNAL OF HEPATOLOGY

An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

(2017) Xiao-Jing Zhang et al.   NATURE MEDICINE

Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors

(2017) Bora Inceoglu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Metabolomics and eicosanoid analysis identified serum biomarkers for distinguishing hepatocellular carcinoma from hepatitis B virus-related cirrhosis

(2017) Zi-Gang Gong et al.   Oncotarget

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

(2017) Wenliang Zhang et al.   Scientific Reports

Docosapentaenoic acid derived metabolites and mediators – The new world of lipid mediator medicine in a nutshell

(2016) Karsten-H. Weylandt   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeted analysis of omega-6-derived oxylipins and parent polyunsaturated fatty acids in serum of hepatitis B virus-related hepatocellular carcinoma patients

(2016) Yonghai Lu et al.   Metabolomics

Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway

(2016) Huanhuan Chen et al.   ONCOLOGY REPORTS

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

(2016) Ken Kojo et al.   Scientific Reports

Transient Receptor Potential Vanilloid 1 Gene Deficiency Ameliorates Hepatic Injury in a Mouse Model of Chronic Binge Alcohol-Induced Alcoholic Liver Disease

(2015) Huilin Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids

(2015) Giuseppe Astarita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity

(2015) Shiyun Pu et al.   BRITISH JOURNAL OF PHARMACOLOGY

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling

(2015) Thomas Horn et al.   PROGRESS IN LIPID RESEARCH

Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease—A pilot study

(2015) Dominika Maciejewska et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis

(2014) Rohit Loomba et al.   JOURNAL OF LIPID RESEARCH

Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

(2014) Milos Lazic et al.   PLoS One

Inhibition of 5-Lipoxygenase Pathway Attenuates Acute Liver Failure by Inhibiting Macrophage Activation

(2014) Lu Li et al.   Journal of Immunology Research

15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation

(2013) Jun Ma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

(2013) Miriam S. N. Hohmann et al.   Biomed Research International

Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors

(2012) Polamarasetty Aparoy et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo

(2012) Xi-Ming Xu et al.   Hepatobiliary & Pancreatic Diseases International

Lipidic last breath of life in patients with alcoholic liver disease

(2012) Joanna Raszeja-Wyszomirska et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

(2011) Romina Lomonaco et al.   HEPATOLOGY

Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma

(2011) Ole Ammerpohl et al.   INTERNATIONAL JOURNAL OF CANCER

Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease

(2010) Marcos Martínez-Clemente et al.   HEPATOLOGY

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor α-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice

(2009) Marcos Martínez-Clemente et al.   HEPATOLOGY