Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma

Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

(2021) Mana Taki et al.   CLINICAL CANCER RESEARCH

Discovery of a selective inhibitor of doublecortin like kinase 1

(2020) Fleur M. Ferguson et al.   Nature Chemical Biology

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer

(2019) Joe Yeong et al.   Journal for ImmunoTherapy of Cancer

Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy

(2019) Rama Soundararajan et al.   Cancers

DCLK1 INTEGRATES INDUCTION OF TRIB3, EMT, DRUG RESISTANCE, and POOR PROGNOSIS IN COLORECTAL CANCER

(2019) Shunichiro Makino et al.   CARCINOGENESIS

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

(2019) Yuanyuan Jiang et al.   CANCER LETTERS

Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy

(2019) Jeffrey C. Thompson et al.   LUNG CANCER

DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-κB pathway in colorectal cancer

(2018) Weiying Liu et al.   INTERNATIONAL JOURNAL OF CANCER

An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use

(2018) Jeffrey Chun Tatt Lim et al.   PATHOLOGY

Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

(2018) Mana Taki et al.   Nature Communications

Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)

(2018) Young Kwang Chae et al.   Scientific Reports

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer

(2018) Li Wang et al.   Nature Communications

Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy

(2017) Cristina Maccalli et al.   IMMUNOLOGICAL INVESTIGATIONS

Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

(2017) Parthasarathy Chandrakesan et al.   Molecular Cancer

Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1

(2017) Yu Ikezono et al.   MOLECULAR CANCER RESEARCH

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

(2017) Geou-Yarh Liou et al.   Cell Reports

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

(2016) C. Benedikt Westphalen et al.   Cell Stem Cell

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases

(2016) Charles B Nguyen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

(2016) Yaqing Zhang et al.   GUT

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism

(2015) Sripathi M. Sureban et al.   Oncotarget

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma

(2015) Nathaniel Weygant et al.   Oncotarget

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism

(2014) Sripathi M. Sureban et al.   CANCER LETTERS

Tumor Plasticity Interferes with Anti-Tumor Immunity

(2014) Salem Chouaib et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiplexed immunohistochemistry, imaging, and quantitation: A review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis

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Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

(2014) Nathaniel Weygant et al.   Molecular Cancer

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Recent progress in pancreatic cancer

(2013) Christopher L. Wolfgang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis

(2013) J. M. Low-Marchelli et al.   CANCER RESEARCH

Immunology of cancer stem cells in solid tumours. A review

(2013) Cristina Maccalli et al.   EUROPEAN JOURNAL OF CANCER

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4

(2013) A. Volonte et al.   JOURNAL OF IMMUNOLOGY

DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer

(2013) Sripathi M. Sureban et al.   PLoS One

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism

(2011) S. M. Sureban et al.   CANCER RESEARCH

Breast cancer subtypes and survival in Chinese women with operable primary breast cancer

(2011) Zhao-sheng Li et al.   Chinese Journal of Cancer Research

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

(2011) Sripathi M Sureban et al.   JOURNAL OF NANOBIOTECHNOLOGY

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL