Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase

(2016) Nathaniel Weygant et al.   CANCER RESEARCH

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

(2016) C. Benedikt Westphalen et al.   Cell Stem Cell

Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases

(2015) Naushad Ali et al.   Oncotarget

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma

(2015) Nathaniel Weygant et al.   Oncotarget

The NOTCH signaling pathway in normal and malignant blood cell production

(2015) Sukanya Suresh et al.   Journal of Cell Communication and Signaling

DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition

(2015) Parthasarathy Chandrakesan et al.   Oncotarget

XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism

(2014) Sripathi M. Sureban et al.   CANCER LETTERS

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

(2014) Nathaniel Weygant et al.   Molecular Cancer

Inhibition of NF- B-Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells

(2013) E. Cosimo et al.   CLINICAL CANCER RESEARCH

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2

(2013) Weiguo Zou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Utility of a bacterial infection model to study epithelial–mesenchymal transition, mesenchymal–epithelial transition or tumorigenesis

(2013) P Chandrakesan et al.   ONCOGENE

DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer

(2013) Sripathi M. Sureban et al.   PLoS One

Differential Effects of β-catenin and NF-κB Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

(2013) Parthasarathy Chandrakesan et al.   PLoS One

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design

(2012) Salvador J. Diaz-Cano   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism

(2011) S. M. Sureban et al.   CANCER RESEARCH

Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial Infection

(2011) Parthasarathy Chandrakesan et al.   INFECTION AND IMMUNITY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma

(2011) Kenneth J Vega et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Stem cells and their implications for colorectal cancer

(2011) Sebastian S. Zeki et al.   Nature Reviews Gastroenterology & Hepatology

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

(2011) Sripathi M Sureban et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nerve Growth Factor in Cancer Cell Death and Survival

(2011) Niamh Molloy et al.   Cancers

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

(2011) Kenneth C. Valkenburg et al.   Cancers

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

(2010) Annabelle Lewis et al.   GUT

Long-lived Min Mice Develop Advanced Intestinal Cancers through a Genetically Conservative Pathway

(2009) R. B. Halberg et al.   CANCER RESEARCH

Selective Blockade of DCAMKL-1 Results in Tumor Growth Arrest by a Let-7a MicroRNA-Dependent Mechanism

(2009) Sripathi M. Sureban et al.   GASTROENTEROLOGY

Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase-Like-1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple Intestinal Neoplasia Mice

(2007) Randal May et al.   STEM CELLS