PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State

Circulating tumor cell profiling for precision oncology

(2021) Mahmoud Labib et al.   Molecular Oncology

High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device

(2021) Alessandra Marrella et al.   PLoS One

Detection of clustered circulating tumour cells in early breast cancer

(2021) Ilona Krol et al.   BRITISH JOURNAL OF CANCER

A new insight to deformability correlation of circulating tumor cells with metastatic behavior by application of a new deformability-based microfluidic chip

(2021) Maziar Hakim et al.   ANALYTICA CHIMICA ACTA

The functional activity of E-cadherin controls tumor cell metastasis at multiple steps

(2020) Tae-Young Na et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Label-Free Isolation of Heterogeneous Circulating Tumor Cells and CTC Clusters from Non-Small-Cell Lung Cancer Patients

(2020) Mina Zeinali et al.   Cancers

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

(2020) Samuel Amintas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comparison of microfluidic methods for high-throughput cell deformability measurements

(2020) Marta Urbanska et al.   NATURE METHODS

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer cells display increased migration and deformability in pace with metastatic progression

(2020) Zhenhui Liu et al.   FASEB JOURNAL

Circulating tumor cells: Ready for translation?

(2020) Zoi Diamantopoulou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

(2020) Irene Schiano Lomoriello et al.   Nature Communications

Regulation of Collective Metastasis by Nanolumenal Signaling

(2020) Emma D. Wrenn et al.   CELL

Mechanical Adaptability of Tumor Cells in Metastasis

(2020) Valentin Gensbittel et al.   DEVELOPMENTAL CELL

Capture of Circulating Tumour Cell Clusters Using Straight Microfluidic Chips

(2019) Arutha Kulasinghe et al.   Cancers

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow

(2019) Ying Xin et al.   BIOPHYSICAL JOURNAL

Phenotypic Profiling of Circulating Tumor Cells in Metastatic Prostate Cancer Patients Using Nanoparticle-Mediated Ranking

(2019) Brenda J. Green et al.   ANALYTICAL CHEMISTRY

Circulating Tumor Cells: State-of-the-art Update on Technologies and Clinical Applications

(2019) Kristofor Yap et al.   Current Hematologic Malignancy Reports

The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models

(2019) Cleris et al.   Cells

Circulating Tumor Cell-Neutrophil Tango along the Metastatic Process

(2019) Massimo Saini et al.   CANCER RESEARCH

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Perspective on Circulating Tumor Cell Clusters: Why It Takes a Village to Metastasize

(2018) Mario Giuliano et al.   CANCER RESEARCH

Mechanotransduction in tumor progression: The dark side of the force

(2018) Florence Broders-Bondon et al.   JOURNAL OF CELL BIOLOGY

Biophysical isolation and identification of circulating tumor cells

(2017) James Che et al.   LAB ON A CHIP

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

(2017) Heather C. Bruner et al.   Cold Spring Harbor Perspectives in Biology

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

(2017) Sam H. Au et al.   Scientific Reports

Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer

(2016) Chun Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Circulating tumor cell clusters: What we know and what we expect (Review)

(2016) Yupeng Hong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Clusters of circulating tumor cells traverse capillary-sized vessels

(2016) Sam H. Au et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction in cancer

(2016) LiKang Chin et al.   Current Opinion in Chemical Engineering

Deformability-based circulating tumor cell separation with conical-shaped microfilters: Concept, optimization, and design criteria

(2015) Mohammad Aghaamoo et al.   Biomicrofluidics

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy

(2015) S. Maheswaran et al.   CANCER RESEARCH

Velocity valleys enable efficient capture and spatial sorting of nanoparticle-bound cancer cells

(2015) Justin D. Besant et al.   Nanoscale

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

(2015) Oliver Otto et al.   NATURE METHODS

HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR

(2015) S Ingthorsson et al.   ONCOGENE

Deformability of Tumor Cells versus Blood Cells

(2015) Josephine Shaw Bagnall et al.   Scientific Reports

Nanoparticle-Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations

(2014) Reza M. Mohamadi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Tissue cohesion and the mechanics of cell rearrangement

(2014) R. David et al.   DEVELOPMENT

A novel microchannel-based device to capture and analyze circulating tumor cells (CTCs) of breast cancer

(2014) REZA RIAHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion

(2014) Lukas D. Osborne et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative microfluidic biomolecular analysis for systems biology and medicine

(2013) Yong Zeng et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Single cell rheometry with a microfluidic constriction: Quantitative control of friction and fluid leaks between cell and channel walls

(2013) Pascal Preira et al.   Biomicrofluidics

Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer

(2013) M Iwatsuki et al.   BRITISH JOURNAL OF CANCER

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Regulation of the Epithelial-Mesenchymal Transition by Claudin-3 and Claudin-4

(2013) Xinjian Lin et al.   PLoS One

Characterizing deformability and surface friction of cancer cells

(2013) S. Byun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

Quantitative Diagnosis of Malignant Pleural Effusions by Single-Cell Mechanophenotyping

(2013) H. T. K. Tse et al.   Science Translational Medicine

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient

(2012) HeeSu Byun et al.   Acta Biomaterialia

Circulating Tumor Cells: Liquid Biopsy of Cancer

(2012) C. Alix-Panabieres et al.   CLINICAL CHEMISTRY

Microfluidics and Circulating Tumor Cells

(2012) Yi Dong et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells

(2012) Wenwei Xu et al.   PLoS One

Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells

(2012) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinspired multivalent DNA network for capture and release of cells

(2012) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deformability-based cell classification and enrichment using inertial microfluidics

(2011) Soojung Claire Hur et al.   LAB ON A CHIP

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

(2010) S. L. Stott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Mechanics: Dissecting the Physical Responses of Cells to Force

(2009) Brenton D. Hoffman et al.   Annual Review of Biomedical Engineering

Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

(2009) Jason P. Gleghorn et al.   LAB ON A CHIP

AFM indentation study of breast cancer cells

(2008) Q.S. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL

AFM-based analysis of human metastatic cancer cells

(2008) Sarah E Cross et al.   NANOTECHNOLOGY