Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and regulatory challenge

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

HLA-haploidentical stem cell transplantation after removal of   + T and B cells in children with nonmalignant disorders

(2014) A. Bertaina et al.   BLOOD

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells

(2014) S. Gill et al.   BLOOD

Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation

(2014) F Baron et al.   BONE MARROW TRANSPLANTATION

Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease

(2014) Zheng Xiang et al.   CANCER CELL

Gene and Cell Therapy Funding Opportunities in Horizon 2020: An Overview for 2014–2015

(2014) David Gancberg et al.   HUMAN GENE THERAPY

Requirements for Effective Antitumor Responses of TCR Transduced T Cells

(2014) M. A. de Witte et al.   JOURNAL OF IMMUNOLOGY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity

(2014) Wouter Scheper et al.   Frontiers in Immunology

Myeloablative T cell-depleted alloSCT with early sequential prophylactic donor lymphocyte infusion is an efficient and safe post-remission treatment for adult ALL

(2013) M Eefting et al.   BONE MARROW TRANSPLANTATION

Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation

(2013) Nicoletta Cieri et al.   IMMUNOLOGICAL REVIEWS

Hunting for clinical translation with innate-like immune cells and their receptors

(2013) W Scheper et al.   LEUKEMIA

The regulatory landscape for actively personalized cancer immunotherapies

(2013) Cedrik M Britten et al.   NATURE BIOTECHNOLOGY

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies

(2013) Jennifer D. Stone et al.   Frontiers in Immunology

TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

(2013) Andre Kunert et al.   Frontiers in Immunology

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

(2012) N. Vey et al.   BLOOD

Negative depletion of CD3+ and TcRαβ+ T cells

(2012) Rupert Handgretinger   CURRENT OPINION IN HEMATOLOGY

Comparative Outcomes of Donor Graft CD34+Selection and Immune Suppressive Therapy As Graft-Versus-Host Disease Prophylaxis for Patients With Acute Myeloid Leukemia in Complete Remission Undergoing HLA-Matched Sibling Allogeneic Hematopoietic Cell Transplantation

(2012) Marcelo C. Pasquini et al.   JOURNAL OF CLINICAL ONCOLOGY

Re-engineering the European Union Clinical Trials Directive

(2012) MJH Kenter et al.   LANCET

Replication-Competent Retroviruses in Gene-Modified T Cells Used in Clinical Trials: Is It Time to Revise the Testing Requirements?

(2012) Adham S Bear et al.   MOLECULAR THERAPY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Redirecting   T cells against cancer cells by transfer of a broadly tumor-reactive   T-cell receptor

(2011) V. Marcu-Malina et al.   BLOOD

Cancer Immunotherapy Using a Bispecific NK Receptor Fusion Protein that Engages both T Cells and Tumor Cells

(2011) T. Zhang et al.   CANCER RESEARCH

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treating cancer with genetically engineered T cells

(2011) Tristen S. Park et al.   TRENDS IN BIOTECHNOLOGY

Development of Adoptive Cell Therapy for Cancer: A Clinical Perspective

(2010) Robert E. Hawkins et al.   HUMAN GENE THERAPY

V 9V 2 T Lymphocytes Efficiently Recognize and Kill Zoledronate-Sensitized, Imatinib-Sensitive, and Imatinib-Resistant Chronic Myelogenous Leukemia Cells

(2010) M. D'Asaro et al.   JOURNAL OF IMMUNOLOGY

Human Vγ9Vδ2 T cells: From signals to functions

(2010) Steven Nedellec et al.   SEMINARS IN IMMUNOLOGY

Efficient Killing of Human Colon Cancer Stem Cells by    T Lymphocytes

(2009) M. Todaro et al.   JOURNAL OF IMMUNOLOGY

Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy

(2008) Tal I. Arnon et al.   PLoS One