Hunting for clinical translation with innate-like immune cells and their receptors

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Control of Human Viral Infections by Natural Killer Cells

(2013) Stephanie Jost et al.   Annual Review of Immunology

CMV: a warrior against leukemia?

(2013) P. Ljungman   BLOOD

Identification of a cellular ligand for the natural cytotoxicity receptor NKp44

(2013) F. Baychelier et al.   BLOOD

CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia

(2013) M. L. Green et al.   BLOOD

CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML

(2013) S Ito et al.   BONE MARROW TRANSPLANTATION

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells

(2013) Y.-H. Chang et al.   CANCER RESEARCH

Cellular therapy of cancer with natural killer cells—where do we stand?

(2013) Hans G. Klingemann   CYTOTHERAPY

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

(2013) Georg Gasteiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to its HLA-C Ligand

(2013) W. R. Frazier et al.   JOURNAL OF IMMUNOLOGY

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

(2013) W Scheper et al.   LEUKEMIA

Evolutionary implications of a third lymphocyte lineage in lampreys

(2013) Masayuki Hirano et al.   NATURE

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Multifunctional γδ T cells and their receptors for targeted anticancer immunotherapy

(2013) Wouter Scheper et al.   OncoImmunology

Tumor cell recognition by γδ T lymphocytes

(2013) Daniel V. Correia et al.   OncoImmunology

Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation

(2012) Lena Oevermann et al.   Annals of the New York Academy of Sciences

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

(2012) N. Vey et al.   BLOOD

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

γδ-T cells: an unpolished sword in human anti-infection immunity

(2012) Jian Zheng et al.   Cellular & Molecular Immunology

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR

(2012) Li Bai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

(2012) P. Meij et al.   HAEMATOLOGICA

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Molecular definition of the identity and activation of natural killer cells

(2012) Natalie A Bezman et al.   NATURE IMMUNOLOGY

HLA-C–Dependent Prevention of Leukemia Relapse by Donor ActivatingKIR2DS1

(2012) Jeffrey M. Venstrom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Activating KIR2DS2 and KIR2DS4 Genes after Hematopoietic Cell Transplantation: Relevance to Cytomegalovirus Infection

(2011) Ghislaine M. Gallez-Hawkins et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

T Cell–Depleted Partial Matched Unrelated Donor Transplant for Advanced Myeloid Malignancy: KIR Ligand Mismatch and Outcome

(2011) Daniel Weisdorf et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Redirecting   T cells against cancer cells by transfer of a broadly tumor-reactive   T-cell receptor

(2011) V. Marcu-Malina et al.   BLOOD

Differentiation of human peripheral blood V 1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

(2011) D. V. Correia et al.   BLOOD

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

(2011) B. Foley et al.   BLOOD

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer Immunotherapy Using a Bispecific NK Receptor Fusion Protein that Engages both T Cells and Tumor Cells

(2011) T. Zhang et al.   CANCER RESEARCH

γδ T-APCs: a novel tool for immunotherapy?

(2011) Bernhard Moser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

NK cells engineered to express a GD2-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin

(2011) Ruth Esser et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

(2011) B. Rosental et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Proinflammatory Human Skin-Homing V 9V 2 T Cell Subset with a Potential Role in Psoriasis

(2011) U. Laggner et al.   JOURNAL OF IMMUNOLOGY

Donor KIR haplotype B improves progression-free and overall survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma

(2011) N Kröger et al.   LEUKEMIA

KIR2DS1 genotype predicts for complete cytogenetic response and survival in newly diagnosed chronic myeloid leukemia patients treated with imatinib

(2011) D Marin et al.   LEUKEMIA

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

(2011) Nicolas F Delahaye et al.   NATURE MEDICINE

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

(2011) S. Lopez-Verges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

The role of V 2-negative    T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation

(2010) A. Knight et al.   BLOOD

Human    T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

(2010) A. Maniar et al.   BLOOD

Human cytomegalovirus elicits fetal γδ T cell responses in utero

(2010) David Vermijlen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune reconstitution after haploidentical hematopoietic cell transplantation: impact of reduced intensity conditioning and CD3/CD19 depleted grafts

(2010) B Federmann et al.   LEUKEMIA

The Effect of Single and Combined Activating Killer Immunoglobulin-like Receptor Genotypes on Cytomegalovirus Infection and Immunity after Hematopoietic Cell Transplantation

(2009) John A. Zaia et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Clinical and immunological evaluation of zoledronate-activated Vγ9γδ T-cell-based immunotherapy for patients with multiple myeloma

(2009) Yu Abe et al.   EXPERIMENTAL HEMATOLOGY

Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors

(2009) Victoria Marcu-Malina et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

(2009) Thorsten Graef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

(2009) Cameron S. Brandt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A

(2009) D N Eissens et al.   LEUKEMIA

Effects of activating NK cell receptor expression and NK cell reconstitution on the outcomes of unrelated donor hematopoietic cell transplantation for hematologic malignancies

(2009) B M Triplett et al.   LEUKEMIA

KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia

(2009) R Willemze et al.   LEUKEMIA

Cross-presenting human    T cells induce robust CD8+    T cell responses

(2009) M. Brandes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial

(2008) S. Arai et al.   CYTOTHERAPY

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy

(2008) Tal I. Arnon et al.   PLoS One