Article
Engineering, Biomedical
Melissa Alvarado-Velez, Syed Faaiz Enam, Nalini Mehta, Johnathan G. Lyon, Michelle C. LaPlaca, Ravi V. Bellamkonda
Summary: The development of immunosuppressive hydrogels for stem cell delivery, such as the agarose-FasL hydrogel in this study, has shown promising results in enhancing the benefits of stem cell therapy for traumatic brain injury. By reducing host cytotoxic CD8(+) T cell populations, increasing the survival of transplanted allogeneic MSCs, and elevating the expression of neurotrophic factors in the injury penumbra, this approach holds potential for improving therapeutic outcomes in TBI cases.
Article
Medicine, General & Internal
Martina Hinterleitner, Clemens Hinterleitner, Elke Malenke, Birgit Federmann, Ursula Holzer, Martin Mueller, Wolfgang A. Bethge, Stefan Wirths
Summary: Reconstitution of immune cells after stem cell transplantation takes place in different stages. This study investigated the formation of new B cells in patients who received haploidentical stem cell transplantation with CD3 and CD19 depletion. It was found that antibody-secreting cells (ASC) reconstituted very early, before the detection of naive and memory B cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Priscila Ferreira Slepicka, Mahboubeh Yazdanifar, Alice Bertaina
Summary: This article discusses the conventional and unconventional immunological mechanisms underlying the development of immune tolerance in solid organ transplant (SOT) recipients, as well as how these mechanisms can inform clinical progress. Specifically, recent mechanistic studies elucidating the role of regulatory cells in dampening cytotoxic immune reactivity and fostering a tolerogenic environment are reviewed. The understanding of regulatory cells can shape graft engineering and other therapeutic strategies to improve long-term outcomes for patients receiving hematopoietic stem cell transplantation (HSCT) and SOT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jonathan Bordat, Sebastien Maury, Mathieu Leclerc
Summary: Allo-HSCT recipients are highly vulnerable to COVID-19 due to immunodeficiency, and changes in clinical practice have been implemented to reduce the risk. mRNA vaccines have shown effectiveness in preventing severe forms of the disease, but Allo-HSCT recipients may have a poor response to vaccination. Challenges include adapting vaccine protection to emerging variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biophysics
Caroline Ritacco, Gregory Ehx, Celine Gregoire, Coline Daulne, Evelyne Willems, Sophie Servais, Yves Beguin, Frederic Baron
Summary: Research has shown that different subsets of regulatory T cells (Treg) exhibit varying abilities to phosphorylate STAT5 in response to IL-2 or IL-7 stimulation, and the frequencies of these Treg subtypes may change in patients with chronic graft-versus-host disease (GVHD).
BONE MARROW TRANSPLANTATION
(2021)
Review
Immunology
Richard J. Lin, Harold K. Elias, Marcel R. M. van den Brink
Summary: Older patients with hematologic malignancies are increasingly undergoing allogeneic hematopoietic cell transplantation, with aging-related thymic dysfunction and other aging hallmarks potentially impacting immune reconstitution post-transplantation. Mechanism-based therapeutic interventions are being discussed to address these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Wang, Meng Yuan, Guanghua Zhu, Runhui Wu, Chenguang Jia, Bin Wang, Jie Zheng, Jie Ma, Maoquan Qin, Sidan Li
Summary: This study analyzed the immune reconstitution of pediatric patients with aplastic anemia after hematopoietic stem-cell transplantation (HSCT) and found that early rapid immune reconstitution is a good predictor of clinical prognosis in children with AA.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Oron Goldstein, Edna Ayerim Mandujano-Tinoco, Tom Levy, Shani Talice, Tal Raveh, Orly Gershoni-Yahalom, Ayelet Voskoboynik, Benyamin Rosental
Summary: Botryllus schlosseri, a colonial tunicate closest to vertebrates, lacks adaptive immunity but possesses unique characteristics making it a valuable model for studying innate immunity mechanisms. Studies in B. schlosseri have revealed a framework underlying the loss of tolerance to allogeneic tissues and provided insights into hematopoietic stem cell transplantation. Understanding the successful innate immune tolerance in B. schlosseri can potentially offer novel insights and modulations of immune processes in humans.
Article
Immunology
Jintao Xia, Xuejie Li, Genyong Gui, Jian Wu, Shengnan Gong, Yuxin Shang, Jun Fan
Summary: This study evaluated the early immune response of recipients with disparate HCMV outcomes and found that HCMV-specific IFN-gamma secreting cells, HCMV IgG, and absolute lymphocyte count could represent the humoral and cellular immune response. Early monitoring of these immune markers could enable prediction of HCMV outcomes posttransplant and assessment of the severity of HCMV DNAemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cecile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati, Sebastien Maury
Summary: Hematopoietic stem cell transplant recipients show lower immune response to BNT162b2 mRNA vaccine after 6 months, with peak antibody levels predicting persistent protection. Immunosuppressive drugs and low lymphocyte counts correlate with lower antibody levels.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Hematology
Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Summary: This study reveals the functional compensation and complementation of IRAK1 in leukemic cells upon inhibition of IRAK4. Cotargeting IRAK1 and IRAK4 is necessary to suppress leukemic stem/progenitor cell function and induce differentiation. IRAK1 and IRAK4 maintain the undifferentiated state of MDS/AML LSPCs through noncanonical MyD88-independent pathways.
Review
Hematology
Elizabeth Herrity, Mariana Pinto Pereira, Dennis Dong Hwan Kim
Summary: This study describes the mechanistic diversity of relapse after hematopoietic stem cell transplantation and emphasizes the importance of these mechanisms in treatment selection and future research inspiration.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Anna Soderstrom, Sofie Vonlanthen, Kerstin Jonsson-Videsater, Stephan Mielke, Hannes Lindahl, Johan Torlen, Michael Uhlin
Summary: This study found that measuring TREC levels can predict the prognosis of adult AML patients after bone marrow transplantation, especially overall survival. Lower TREC levels were associated with viral infections and CMV reactivation. KREC levels were not associated with clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Engineering, Multidisciplinary
Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao
Summary: Innate immune cells, particularly macrophages, play critical roles in transplant response. Macrophages, as the predominant infiltrated cells in allografts, have diverse functions and can either promote or protect against graft rejection. Understanding the complex roles of macrophages and developing specific immunosuppressive drugs targeting macrophages are crucial for improving the long-term survival of organ grafts.
Review
Biochemistry & Molecular Biology
Yuhuai Xie, Yuanyuan Wei
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in regulating antimicrobial responses in the host innate immune system, impacting immune cell development and function, inflammatory processes, and antiviral mechanisms through interactions with DNA, RNA, or proteins. Dysregulation of lncRNA function is linked to various human non-infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Loes L. Cornelissen, Aukje L. Kreuger, Camila Caram-Deelder, Menno Huisman, Rutger A. Middelburg, Jean Louis H. Kerkhoffs, Peter A. von Dem Borne, Erik A. M. Beckers, Karen M. K. de Vooght, Jurgen Kuball, Johanna G. van der Bom, Jaap Jan Zwaginga
Summary: This study aimed to investigate whether cardiovascular risk factors can predict intracranial hemorrhage in patients with acute leukemia. The case-control study found that pre-existing hypertension and ischemic heart disease were associated with an increased risk of intracranial hemorrhage.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Review
Virology
Anke Janssen, Eline van Diest, Anna Vyborova, Lenneke Schrier, Anke Bruns, Zsolt Sebestyen, Trudy Straetemans, Moniek de Witte, Juergen Kuball
Summary: In the complex interaction between inflammation and graft-versus-host disease after allogeneic stem cell transplantation, viral reactivations play a significant role in morbidity and mortality. Delaying the reconstitution of alpha beta T cells enables the use of gamma delta T cells to control viral reactivations, potentially impacting both viral infections and hematological malignancies.
Article
Oncology
Tassilo L. A. Wachsmann, Anne K. Wouters, Dennis F. G. Remst, Renate S. Hagedoorn, Miranda H. Meeuwsen, Eline van Diest, Jeanette Leusen, Jurgen Kuball, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Summary: This study compared the activity of CAR T cells and engineered TCR T cells in targeting CD20 antigen, and found that CAR T cells were more potent in the short term but their expansion was impaired with increased antigen exposure, while eTCR T cells performed better under high antigenic pressure.
Article
Hematology
Annoek E. C. Broers, Cornelis N. de Jong, Katerina Bakunina, Mette D. Hazenberg, Marinus van Marwijk Kooy, Marco R. de Groot, Michel van Gelder, Jurgen Kuball, Bronno van der Holt, Ellen Meijer, Jan J. Cornelissen
Summary: This study found that the combination of PT-Cy and a short course of CsA significantly reduces the occurrence of severe GVHD and improves GVHD-free, relapse-free survival in patients undergoing nonmyeloablative alloHSCT.
Article
Oncology
P. J. Hayden, C. Roddie, P. Bader, G. W. Basak, H. Bonig, C. Bonini, C. Chabannon, F. Ciceri, S. Corbacioglu, R. Ellard, F. Sanchez-Guijo, U. Jaeger, M. Hildebrandt, M. Hudecek, M. J. Kersten, U. Koehl, J. Kuball, S. Mielke, M. Mohty, J. Murray, A. Nagler, J. Rees, C. Rioufol, R. Saccardi, J. A. Snowden, J. Styczynski, M. Subklewe, C. Thieblemont, M. Topp, A. U. Ispizua, D. Chen, R. Vrhovac, J. G. Gribben, N. Kroeger, H. Einsele, I Yakoub-Agha
Summary: Several autologous chimeric antigen receptor T-cell (CAR-T) products targeting CD19 have been approved in Europe, with more approvals for different diseases expected in the near future. The European Society for Blood and Marrow Transplantation (EBMT)-Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association collaborated to provide best practice recommendations to support consistent and high-quality care in this rapidly advancing field.
ANNALS OF ONCOLOGY
(2022)
Correction
Biophysics
Michelle J. M. Janssen, Anke H. W. Bruns, Frans M. Verduyn Lunel, Reinier A. P. Raijmakers, Roel J. de Weijer, Nening M. Nanlohy, Gaby P. Smits, Debbie van Baarle, Jurgen Kuball
BONE MARROW TRANSPLANTATION
(2022)
Letter
Hematology
Donal P. McLornan, Luuk Gras, Ivonne Martin, Tiarlan Sirait, Thomas Schroeder, Igor Wolfgang Blau, Juergen Kuball, Jenny Byrne, Matthew Collin, Michael Stadler, Deborah Desmier, Urpu Salmenniemi, Pavel Jindra, Natalia Mikhailova, Stig Lenhoff, Jose Rifon, Marie Robin, Montserrat Rovira, Hendrik Veelken, Alicja Sadowska-Klasa, Marco Zecca, Patrick J. Hayden, Tomasz Czerw, Juan Carlos Hernandez-Boluda, Ibrahim Yakoub-Agha
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Johanna F. Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Amber K. L. Wezenaar, Esmee J. van Vliet, Jens Puschhof, Peter Brazda, Inez Johanna, Angelo D. Meringa, Heggert G. Rebel, Maj-Britt Buchholz, Mario Barrera Roman, Amber L. Zeeman, Sam de Blank, Domenico Fasci, Maarten H. Geurts, Annelisa M. Cornel, Else Driehuis, Rosemary Millen, Trudy Straetemans, Mara J. T. Nicolasen, Tineke Aarts-Riemens, Hendrikus C. R. Ariese, Hannah R. Johnson, Ravian L. van Ineveld, Froso Karaiskaki, Oded Kopper, Yotam E. Bar-Ephraim, Kai Kretzschmar, Alexander M. M. Eggermont, Stefan Nierkens, Ellen J. Wehrens, Henk G. Stunnenberg, Hans Clevers, Jurgen Kuball, Zsolt Sebestyen, Anne C. Rios
Summary: This study utilizes a system called BEHAV3D to investigate the dynamic interactions between immune cells and patient cancer organoids. By live-tracking a large number of engineered T cells cultured with patient-derived solid-tumor organoids, a cluster of "super engager" T cells with potent serial killing capacity is identified. The study also examines cancer metabolome-sensing engineered T cells (TEGs) and identifies behavior-specific gene signatures in these cells. Additionally, it demonstrates the ability of type I interferon to prime resistant organoids for TEG-mediated killing.
NATURE BIOTECHNOLOGY
(2022)
Article
Immunology
Eline van Diest, Mara J. T. Nicolasen, Lovro Kramer, Jiali Zheng, Patricia Hernandez-Lopez, Dennis X. Beringer, Jurgen Kuball
Summary: In this study, we developed a novel T cell engager concept called GAB by utilizing γδTCR as a tumor targeting domain. The γδ ECTO-alpha CD3-dimer design was found to be superior in function compared to monomers and does not induce T cell activation without simultaneous tumor engagement.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Biophysics
Klaartje Nijssen, Kasper Westinga, Anniek Stuut, Anke Janssen, Anna van Rhenen, Lotte van der Wagen, Laura G. M. Daenen, Rimke Oostvogels, Moniek A. de Witte, Juergen Kuball
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Laura G. M. Daenen, Jan-Tom van der Bruggen, Roos J. Leguit, Lotte E. van der Wagen, Anna van Rhenen, Herman F. Wunderink, Moniek A. de Witte, Anke H. W. Bruns, Jurgen Kuball
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
M. A. de Witte, J. E. Mooyaart, J. D. Hoogenboom, C. Chabannon, F. Malard, A. Ruggeri, J. Kuball
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Thomas Kimman, Anne Slomp, Anne Martens, Sarah Grabherr, Shuang Li, Eline van Diest, Jan Meeldijk, Jurgen Kuball, Monique C. Minnema, Eric Eldering, Niels Bovenschen, Zsolt Sebestyen, Victor Peperzak
Summary: Gene engineered CAR T cells have shown promising initial clinical responses in cancer patients; however, resistance mechanisms in cancer cells can limit the effectiveness of CAR T cell-mediated killing. Serpin B9 expression in cancer cells can lead to resistance towards CAR T cells, and inhibiting or bypassing serpin B9 may improve CAR T cell responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Meeting Abstract
Oncology
Remi Tilmont, Ibrahim Yakoub-Agha, Diderik-Jan Eikema, Nienke Zinger, Mathias Haenel, Nicolaas Schaap, Concepcion Herrera Arroyo, Christine Schuermans, Wolfgang Bethge, Monika Engelhardt, Jurgen Kuball, Mariagrazia Michieli, Natalie Schub, Keith M. O. Wilson, Jean Henri Bourhis, Maria-Victoria Mateos, Neil Rabin, Edgar Jost, Nicolaus Kroger, Jose Ma Moraleda, Simona Sica, Patrick J. Hayden, Meral Beksac, Stefan Schonland, Salomon Manier
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Meeting Abstract
Hematology
Katherine C. Wood, Fabliha A. Chowdhury, Seyed M. Nouraie, Mark T. Gladwin, Adam C. Straub