The m6A-epitranscriptome in brain plasticity, learning and memory

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

(2021) Lina Worpenberg et al.   EMBO JOURNAL

Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

(2021) Yasunori Hayashi et al.   JOURNAL OF NEUROSCIENCE

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

(2021) Lijuan Kan et al.   Nature Communications

Mammalian RNA Decay Pathways Are Highly Specialized and Widely Linked to Translation

(2020) Alex Charles Tuck et al.   MOLECULAR CELL

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

Phase separation provides a mechanism to reduce noise in cells

(2020) A. Klosin et al.   SCIENCE

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

(2020) Jiangtao Yu et al.   Molecular Brain

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

(2020) Min Han et al.   Frontiers in Neuroscience

m6A-binding YTHDF proteins promote stress granule formation

(2020) Ye Fu et al.   Nature Chemical Biology

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

(2020) Pauline Herviou et al.   Nature Communications

Limits in the detection of m6A changes using MeRIP/m6A-seq

(2020) Alexa B. R. McIntyre et al.   Scientific Reports

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

(2020) Sneha Shah et al.   Cell Reports

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA

(2020) Sara Zaccara et al.   CELL

Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling

(2020) Xiandeng Wu et al.   DEVELOPMENTAL CELL

N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2

(2020) Yuan Li et al.   NATURE GENETICS

Decoding the epitranscriptional landscape from native RNA sequences

(2020) Piroon Jenjaroenpun et al.   NUCLEIC ACIDS RESEARCH

Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies

(2020) Zhen-Hua Chen et al.   Cell Death & Disease

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

(2020) Raeann Goering et al.   eLife

How Do You Identify m6 A Methylation in Transcriptomes at High Resolution? A Comparison of Recent Datasets

(2020) Charlotte Capitanchik et al.   Frontiers in Genetics

An Emerging Role of m6A in Memory: A Case for Translational Priming

(2020) Amanda M. Leonetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epitranscriptomic regulation by m6A RNA methylation in brain development and diseases

(2020) Anil K Chokkalla et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain

(2020) Sachithrani U. Madugalle et al.   TRENDS IN NEUROSCIENCES

New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

(2020) Georgia Dermentzaki et al.   Frontiers in Molecular Biosciences

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

(2020) He Huang et al.   eNeuro

The epitranscriptome in stem cell biology and neural development

(2020) Caroline Vissers et al.   NEUROBIOLOGY OF DISEASE

FMRP links optimal codons to mRNA stability in neurons

(2020) Huan Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation

(2019) Xiandeng Wu et al.   MOLECULAR CELL

Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice

(2019) Yiqin Wang et al.   Epigenomics

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTO affects hippocampal function by regulation of BDNF processing

(2019) André Spychala et al.   PLoS One

RNA structure maps across mammalian cellular compartments

(2019) Lei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death

(2019) Xuechai Chen et al.   ACS Chemical Neuroscience

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential

(2019) David F. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

(2019) Junchen Chen et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export

(2019) Brittany M. Edens et al.   Cell Reports

Multivalent m6A motifs promote phase separation of YTHDF proteins

(2019) Yifei Gao et al.   CELL RESEARCH

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

(2019) Xiao-Min Liu et al.   Nature Chemical Biology

DART-seq: an antibody-free method for global m6A detection

(2019) Kate D. Meyer   NATURE METHODS

Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice

(2019) Yuhang Cao et al.   HUMAN MOLECULAR GENETICS

The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs

(2019) Phillip J. Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

(2019) Katherine I. Zhou et al.   MOLECULAR CELL

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Transient Focal Ischemia Significantly Alters the m 6 A Epitranscriptomic Tagging of RNAs in the Brain

(2019) Anil K. Chokkalla et al.   STROKE

Accurate detection of m6A RNA modifications in native RNA sequences

(2019) Huanle Liu et al.   Nature Communications

The neuronal stimulation–transcription coupling map

(2019) Kelsey M Tyssowski et al.   CURRENT OPINION IN NEUROBIOLOGY

The m6A epitranscriptome: transcriptome plasticity in brain development and function

(2019) Ido Livneh et al.   NATURE REVIEWS NEUROSCIENCE

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

(2019) Huan Xu et al.   NEURON

Regulation of Neuronal Differentiation, Function, and Plasticity by Alternative Splicing

(2018) Elisabetta Furlanis et al.   Annual Review of Cell and Developmental Biology

FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling

(2018) Huajie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FTO, m6 Am , and the hypothesis of reversible epitranscriptomic mRNA modifications

(2018) Jan Mauer et al.   FEBS LETTERS

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

The m6A-epitranscriptomic signature in neurobiology:from neurodevelopment to brain plasticity

(2018) Jocelyn Widagdo et al.   JOURNAL OF NEUROCHEMISTRY

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

(2018) Yang Wang et al.   NATURE NEUROSCIENCE

Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

(2018) Daria Merkurjev et al.   NATURE NEUROSCIENCE

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

(2018) Georgi Tushev et al.   NEURON

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

(2018) Jessica L. Koranda et al.   NEURON

Controlling compartmentalization by non-membrane-bound organelles

(2018) Richard J. Wheeler et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

A liquid phase of synapsin and lipid vesicles

(2018) Dragomir Milovanovic et al.   SCIENCE

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

(2018) Nancy Standart et al.   TRENDS IN GENETICS

Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency

(2018) Annita Louloupi et al.   Cell Reports

METTL3-mediated m6A modification is required for cerebellar development

(2018) Chen-Xin Wang et al.   PLOS BIOLOGY

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

(2018) Menglong Zeng et al.   CELL

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

METTL3 regulates WTAP protein homeostasis

(2018) Melissa Sorci et al.   Cell Death & Disease

The m6A-methylase complex recruits TREX and regulates mRNA export

(2018) Simon Lesbirel et al.   Scientific Reports

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

(2018) Rong Wu et al.   CELL RESEARCH

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

(2018) Zeyu Zhang et al.   CELL RESEARCH

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

(2018) Subbarayalu Panneerdoss et al.   Science Advances

m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

(2017) Shengdong Ke et al.   GENES & DEVELOPMENT

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome

(2017) A. Emilia Arguello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation

(2017) Brandon J Walters et al.   NEUROPSYCHOPHARMACOLOGY

Dynamic m6A modification regulates local translation of mRNA in axons

(2017) Jun Yu et al.   NUCLEIC ACIDS RESEARCH

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N 6 -methyladenosine is required for the hypoxic stabilization of specific mRNAs

(2017) Nate J. Fry et al.   RNA

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation

(2017) Mariana M. Fontes et al.   Scientific Reports

Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function

(2017) Rhonda L. McFleder et al.   Cell Reports

Region-specific RNA m 6 A methylation represents a new layer of control in the gene regulatory network in the mouse brain

(2017) Mengqi Chang et al.   Open Biology

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

Experience-Dependent Accumulation of N 6 -Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

(2016) Jocelyn Widagdo et al.   JOURNAL OF NEUROSCIENCE

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity

(2016) Oriane Mauger et al.   NEURON

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

(2016) Shui Zou et al.   Scientific Reports

Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure

(2015) Shiran Naftelberg et al.   Annual Review of Biochemistry

Intron retention in mRNA: No longer nonsense

(2015) Justin J.-L. Wong et al.   BIOESSAYS

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders

(2015) Jason Radley et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Functions and Dysfunctions of Adult Hippocampal Neurogenesis

(2014) Kimberly M. Christian et al.   Annual Review of Neuroscience

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

(2013) Schraga Schwartz et al.   CELL

Epigenetic regulation of memory formation and maintenance

(2013) I. B. Zovkic et al.   LEARNING & MEMORY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic Mechanisms in Cognition

(2011) Jeremy J. Day et al.   NEURON

Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs

(2010) K. H. Zivraj et al.   JOURNAL OF NEUROSCIENCE

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Synaptic AMPA Receptor Plasticity and Behavior

(2009) Helmut W. Kessels et al.   NEURON

The role of protein synthesis in memory consolidation: Progress amid decades of debate

(2007) Pepe J. Hernandez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY