Multi‐state modeling of G‐protein coupled receptors at experimental accuracy

Structural basis of neuropeptide Y signaling through Y1 receptor

(2022) Chaehee Park et al.   Nature Communications

Sampling alternative conformational states of transporters and receptors with AlphaFold2

(2022) Diego del Alamo et al.   eLife

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

High‐accuracy protein structure prediction in CASP14

(2021) Joana Pereira et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Target classification in the 14th round of the critical assessment of protein structure prediction ( CASP14 )

(2021) Lisa N. Kinch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction

(2021) Lisa N. Kinch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

(2021) Shaoyong Lu et al.   Nature Communications

Applying and improving AlphaFold at CASP14

(2021) John Jumper et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Impact of GPCR Structures on Drug Discovery

(2020) Miles Congreve et al.   CELL

Structural basis of CXC chemokine receptor 2 activation and signalling

(2020) Kaiwen Liu et al.   NATURE

A combined activation mechanism for the glucagon receptor

(2020) Giulio Mattedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into differences in G protein activation by family A and family B GPCRs

(2020) Daniel Hilger et al.   SCIENCE

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

(2019) Shane C. Wright et al.   Nature Communications

HH-suite3 for fast remote homology detection and deep protein annotation

(2019) Martin Steinegger et al.   BMC BIOINFORMATICS

Common activation mechanism of class A GPCRs

(2019) Qingtong Zhou et al.   eLife

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models

(2018) Przemysław Miszta et al.   NUCLEIC ACIDS RESEARCH

Clustering huge protein sequence sets in linear time

(2018) Martin Steinegger et al.   Nature Communications

Exploring the free-energy landscape of GPCR activation

(2018) Raphael Alhadeff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

GPCR-I-TASSER: A Hybrid Approach to G Protein-Coupled Receptor Structure Modeling and the Application to the Human Genome

(2015) Jian Zhang et al.   STRUCTURE

AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility

(2015) Pradeep Anand Ravindranath et al.   PLoS Computational Biology

lDDT: a local superposition-free score for comparing protein structures and models using distance difference tests

(2013) Valerio Mariani et al.   BIOINFORMATICS

GalaxyDock: Protein–Ligand Docking with Flexible Protein Side-chains

(2012) Woong-Hee Shin et al.   Journal of Chemical Information and Modeling

Treatment of Chronic Heart Failure With β-Adrenergic Receptor Antagonists

(2011) Michael R. Bristow   CIRCULATION RESEARCH

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Modern Homology Modeling of G-Protein Coupled Receptors: Which Structural Template to Use?

(2009) Juan Carlos Mobarec et al.   JOURNAL OF MEDICINAL CHEMISTRY