A Biological Rationale for the Disparate Effects of Omega-3 Fatty Acids on Cardiovascular Disease Outcomes

Consistency of Benefit of Icosapent Ethyl by Background Statin Type in REDUCE-IT

(2022) Nickpreet Singh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prevention of Cardiovascular Events and Mortality With Icosapent Ethyl in Patients With Prior Myocardial Infarction

(2022) Prakriti Gaba et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ICOSAPENT ETHYL REDUCES CARDIOVASCULAR RISK SUBSTANTIALLY AND CONSISTENTLY REGARDLESS OF WAIST CIRCUMFERENCE

(2022) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Treatment With Icosapent Ethyl to Reduce Ischemic Events in Patients With Prior Percutaneous Coronary Intervention: Insights From REDUCE‐IT PCI

(2022) Benjamin E. Peterson et al.   Journal of the American Heart Association

Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE)

(2021) Andrew P. Ambrosy et al.   AMERICAN HEART JOURNAL

Mechanistic Insights from REDUCE-IT STRENGTHen the Case Against Triglyceride Lowering as a Strategy for Cardiovascular Disease Risk Reduction

(2021) R. Preston Mason et al.   AMERICAN JOURNAL OF MEDICINE

Omega-3 fatty acids ameliorate vascular inflammation: A rationale for their atheroprotective effects

(2021) Anthony D. Pisaniello et al.   ATHEROSCLEROSIS

EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol

(2021) Miranda L. Jacobs et al.   BIOPHYSICAL JOURNAL

Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

(2021) Ivana Djuricic et al.   Nutrients

Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

(2021) Subodh Verma et al.   CIRCULATION

Are dietary fish oil supplements appropriate for dyslipidemia management? A review of the evidence

(2020) Samuel C.R. Sherratt et al.   CURRENT OPINION IN LIPIDOLOGY

Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid

(2020) R. Preston Mason et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction

(2020) Michelle C. Williams et al.   CIRCULATION

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

(2020) Anandita Pal et al.   FASEB JOURNAL

Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study

(2020) Yoko Kita et al.   Journal of the American Heart Association

Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial

(2020) Matthew J Budoff et al.   EUROPEAN HEART JOURNAL

COVID-19 is, in the end, an endothelial disease

(2020) Peter Libby et al.   EUROPEAN HEART JOURNAL

Mineral oil: safety and use as placebo in REDUCE-IT and other clinical studies

(2020) Brian Olshansky et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

Effects of n-3 Fatty Acid Supplements in Elderly Patients after Myocardial Infarction: A Randomized Controlled Trial

(2020) Are Annesønn Kalstad et al.   CIRCULATION

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

(2020) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease

(2019) R. Preston Mason   Current Atherosclerosis Reports

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

(2019) Trond Vidar Hansen et al.   Frontiers in Pharmacology

The n-3 docosapentaenoic acid (DPA): A new player in the n-3 long chain polyunsaturated fatty acid family

(2019) Gaetan Drouin et al.   BIOCHIMIE

Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques

(2019) Tomohito Sato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles

(2019) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of mineral oil and non-mineral oil placebo on coronary plaque progression by coronary computed tomography angiography

(2019) Suvasini Lakshmanan et al.   CARDIOVASCULAR RESEARCH

Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin

(2018) R. Preston Mason et al.   BIOMEDICINE & PHARMACOTHERAPY

Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

(2018) Jane A Mitchell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

(2018) Samuel C.R. Sherratt et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Unmet Need for Adjunctive Dyslipidemia Therapy in Hypertriglyceridemia Management

(2018) Om P. Ganda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks

(2018) Theingi Aung et al.   JAMA Cardiology

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

(2018) Wenwei Luo et al.   Aging-US

Resolution of inflammation is altered in chronic heart failure and entails a dysfunctional responsiveness of T lymphocytes

(2018) Valerio Chiurchiù et al.   FASEB JOURNAL

Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study

(2018) Aruna D. Pradhan et al.   AMERICAN HEART JOURNAL

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study

(2017) Kazumasa Nosaka et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A randomized controlled trial of eicosapentaenoic acid in patients with coronary heart disease on statins

(2017) Tetsu Watanabe et al.   Journal of Cardiology

Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

(2017) Hodaka Yamada et al.   Nutrition & Metabolism

Omega-3 fatty acids and cytochrome P450-derived eicosanoids in cardiovascular diseases: Which actions and interactions modulate hemodynamics?

(2017) Sara Bonafini et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Effect of Eicosapentaenoic and Docosahexaenoic Acids Added to Statin Therapy on Coronary Artery Plaque in Patients With Coronary Artery Disease: A Randomized Clinical Trial

(2017) Abdulhamied Alfaddagh et al.   Journal of the American Heart Association

Association of Fenofibrate Therapy With Long-term Cardiovascular Risk in Statin-Treated Patients With Type 2 Diabetes

(2017) Marshall B. Elam et al.   JAMA Cardiology

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

(2017) Connor A. Emdin et al.   CIRCULATION

Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes

(2016) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Omega-3 fatty acids, lipid rafts, and T cell signaling

(2016) Tim Y. Hou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eicosapentaenoic Acid Inhibits Oxidation of ApoB-containing Lipoprotein Particles of Different Size In Vitro When Administered Alone or in Combination With Atorvastatin Active Metabolite Compared With Other Triglyceride-lowering Agents

(2016) R. Preston Mason et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet

(2016) Alexandre Pinel et al.   JOURNAL OF LIPID RESEARCH

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis

(2015) Kenneth M. Borow et al.   ATHEROSCLEROSIS

How polyunsaturated fatty acids modify molecular organization in membranes: Insight from NMR studies of model systems

(2015) Saame Raza Shaikh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Haeme oxygenase signalling pathway: implications for cardiovascular disease

(2015) Laura E. Fredenburgh et al.   EUROPEAN HEART JOURNAL

Effects of Eicosapentaenoic Acid on the Cytoprotection Through Nrf2-Mediated Heme Oxygenase-1 in Human Endothelial Cells

(2015) Seung Eun Lee et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA

(2015) Benjamin B. Albert et al.   Scientific Reports

Effects of Fenofibric Acid on Carotid Intima-Media Thickness in Patients With Mixed Dyslipidemia on Atorvastatin Therapy

(2014) Michael H. Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma

(2014) Ryo Nishio et al.   ATHEROSCLEROSIS

Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

(2014) Jordi Heijman et al.   CIRCULATION RESEARCH

Triglycerides on the rise: should we swap seats on the seesaw?

(2014) Peter Libby   EUROPEAN HEART JOURNAL

Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

(2014) Andrew J Cockbain et al.   GUT

Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study

(2014) Masayuki Doi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

(2014) Meng-Han Liu et al.   Frontiers in Physiology

Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome

(2013) Yuji Nishizaki et al.   AMERICAN JOURNAL OF CARDIOLOGY

Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies

(2013) Harold E. Bays et al.   American Journal of Cardiovascular Drugs

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

(2013) Ryo Ito et al.   Journal of Atherosclerosis and Thrombosis

Angiotensin II Impairs Endothelial Nitric-oxide Synthase Bioavailability under Free Cholesterol-enriched Conditions via Intracellular Free Cholesterol-rich Membrane Microdomains

(2013) Eisuke Amiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atorvastatin Active Metabolite Inhibits Oxidative Modification of Small Dense Low-Density Lipoprotein

(2013) Robert F. Jacob et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

n3 PUFAs Reduce Mouse CD4+ T-Cell Ex Vivo Polarization into Th17 Cells

(2013) Jennifer M. Monk et al.   JOURNAL OF NUTRITION

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

(2013) Jeanette Erdmann et al.   NATURE

Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study)

(2013) Rene A. Braeckman et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

Dietary n-3 Polyunsaturated Fatty Acids (PUFA) Decrease Obesity-Associated Th17 Cell-Mediated Inflammation during Colitis

(2012) Jennifer M. Monk et al.   PLoS One

Orally Administered Eicosapentaenoic Acid Induces Rapid Regression of Atherosclerosis Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice

(2011) Kenji Nakajima et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study

(2011) Akira Takaki et al.   Journal of Atherosclerosis and Thrombosis

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

(2011) Saame Raza Shaikh   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Eicosapentaenoic acid (EPA) from highly concentrated n−3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability

(2010) Abbie L. Cawood et al.   ATHEROSCLEROSIS

Cholesterol in Bilayers with PUFA Chains: Doping with DMPC or POPC Results in Sterol Reorientation and Membrane-Domain Formation

(2010) Norbert Kučerka et al.   BIOCHEMISTRY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

(2010) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Glucose promotes membrane cholesterol crystalline domain formation by lipid peroxidation

(2009) Yehudi Self-Medlin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Impact of circulating esterified eicosanoids and other oxylipins on endothelial function

(2009) Gregory C. Shearer et al.   Current Atherosclerosis Reports

The Functional Significance of Lipid Diversity: Orientation of Cholesterol in Bilayers Is Determined by Lipid Species

(2009) Norbert Kučerka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid

(2008) Hideto Yamada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Docosahexaenoic Acid Enhances Segregation of Lipids between Raft and Nonraft Domains: 2H-NMR Study

(2008) Smita P. Soni et al.   BIOPHYSICAL JOURNAL

Circulating Lipid Hydroperoxides Predict Cardiovascular Events in Patients With Stable Coronary Artery Disease

(2008) Mary F. Walter et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY