Article
Cell Biology
Sodiomon B. Sirima, Alphonse Ouedraogo, Alfred B. Tiono, Jean M. Kabore, Edith C. Bougouma, Maurice S. Ouattara, Desire Kargougou, Amidou Diarra, Noelie Henry, Issa N. Ouedraogo, Peter F. Billingsley, Anita Manoj, Yonas Abebe, K. C. Natasha, Adam Ruben, Thomas L. Richie, Eric R. James, Sudhaunshu Joshi, Biraj Shrestha, Kathy Strauss, Kirsten E. Lyke, Christopher Plowe, Gail E. Potter, Catherine Cox, Walter Jones, B. Kim Lee Sim, Stephen L. Hoffman, Matthew B. Laurens
Summary: Despite decades of research, an effective malaria vaccine has not yet been found. A three-dose regimen of Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine) has shown safety and efficacy in malaria-experienced adults in Burkina Faso.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Guohua Zhong, Chunlan Zhuang, Xiaowen Hu, Qi Chen, Zhaofeng Bi, Xinhua Jia, Siying Peng, Yufei Li, Yue Huang, Qiufen Zhang, Ying Hong, Youlin Qiao, Yingying Su, Huirong Pan, Ting Wu, Lihui Wei, Shoujie Huang, Jun Zhang, Ningshao Xia
Summary: A study conducted in China showed that Hepatitis E vaccination during or shortly before pregnancy is not associated with increased risks for both the pregnant women and pregnancy outcomes.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
Mine Durusu Tanriover, Hamdi Levent Doganay, Murat Akova, Hatice Rahmet Guner, Alpay Azap, Sila Akhan, Sukran Kose, Fatma Sebnem Erdinc, Emin Halis Akalin, Omer Fehmi Tabak, Husnu Pullukcu, Ozgur Batum, Serap Simsek Yavuz, Ozge Turhan, Mustafa Taner Yildirmak, Iftihar Koksal, Yesim Tasova, Volkan Korten, Gurdal Yilmaz, Mustafa Kemal Celen, Sedat Altin, Ilhami Celik, Yasar Bayindir, Ilkay Karaoglan, Aydin Yilmaz, Aykut Ozkul, Hazal Gur, Serhat Unal
Summary: The study presented the interim efficacy and safety results of the CoronaVac vaccine in a phase 3 clinical trial in Turkey, demonstrating high efficacy against PCR-confirmed symptomatic COVID-19 with good safety and tolerability profile. Results showed significant differences in the frequency of any adverse events between the vaccine and placebo groups, indicating excellent protective effects of the vaccine.
Article
Immunology
Paul T. Heath, Eva P. Galiza, David Neil Baxter, Marta Boffito, Duncan Browne, Fiona Burns, David R. Chadwick, Rebecca Clark, Catherine A. Cosgrove, James Galloway, Anna L. Goodman, Amardeep Heer, Andrew Higham, Shalini Iyengar, Christopher Jeanes, Philip A. Kalra, Christina Kyriakidou, Judy M. Bradley, Chigomezgo Munthali, Angela M. Minassian, Fiona McGill, Patrick Moore, Imrozia Munsoor, Helen Nicholls, Orod Osanlou, Jonathan Packham, Carol H. Pretswell, Alberto San Francisco Ramos, Dinesh Saralaya, Ray P. Sheridan, Richard Smith, Roy L. Soiza, Pauline A. Swift, Emma C. Thomson, Jeremy Turner, Marianne Elizabeth Viljoen, Louis Fries, Iksung Cho, Irene McKnight, Greg Glenn, E. Joy Rivers, Andreana Robertson, Katia Alves, Kathy Smith, Seth Toback
Summary: In a phase 3 trial, a 2-dose regimen of the NVX-CoV2373 vaccine provided a high level of protection against asymptomatic, symptomatic, and severe COVID-19 for more than 6 months postvaccination. The vaccine showed 100% efficacy against severe disease and 76.3% efficacy against asymptomatic disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Denis Y. Logunov, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Amir I. Tukhvatulin, Olga V. Zubkova, Alina S. Dzharullaeva, Anna V. Kovyrshina, Nadezhda L. Lubenets, Daria M. Grousova, Alina S. Erokhova, Andrei G. Botikov, Fatima M. Izhaeva, Olga Popova, Tatiana A. Ozharovskaya, Ilias B. Esmagambetov, Irina A. Favorskaya, Denis I. Zrelkin, Daria V. Voronina, Dmitry N. Shcherbinin, Alexander S. Semikhin, Yana V. Simakova, Elizaveta A. Tokarskaya, Daria A. Egorova, Maksim M. Shmarov, Natalia A. Nikitenko, Vladimir A. Gushchin, Elena A. Smolyarchuk, Sergey K. Zyryanov, Sergei V. Borisevich, Boris S. Naroditsky, Alexander L. Gintsburg
Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.
Article
Pharmacology & Pharmacy
Yayun Liu, Shiyong Fan, Aijing Xu, Lingling Ge, Xinyu Wang, Xu Dong, Mingxiao Xu, Wenhan Fan, Wu Zhong, Xuesong Liang
Summary: This study investigated the viral replication inhibitory effect of molnupiravir in patients with Omicron variant vaccine breakthrough COVID-19 infection. The results showed that molnupiravir can effectively shorten the viral clearance time, especially in patients who started treatment early and in those who have been vaccinated.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Payam Tabarsi, Nassim Anjidani, Ramin Shahpari, Masoud Mardani, Araz Sabzvari, Babak Yazdani, Hamidreza Kafi, Newsha Fallah, Ali Ebrahimi, Ali Taheri, Nikolai Petrovsky, Saghar Barati
Summary: This study investigated the efficacy and safety of the SpikoGen(R) vaccine. The results showed that a 2-dose regimen of SpikoGen (R) reduced the incidence of COVID-19 and severe disease, and the vaccine was well tolerated.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Elena Esaulenko, Aleksey A. Yakovlev, Genady A. Volkov, Anastasia A. Sukhoruk, Kirill G. Surkov, Peter Kruglyakov, Francisco Diaz-Mitoma
Summary: This study compared the immunogenicity and safety of a 3-antigen hepatitis B vaccine to a single antigen vaccine in adults, finding that the 3-antigen vaccine was noninferior to the single antigen vaccine in terms of seroconversion rates and induced high seroprotection rates. Additionally, there were no safety concerns identified with the 3-antigen vaccine.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Muhammed O. Afolabi, Doudou Sow, Schadrac C. Agbla, El Hadji Babacar Fall, Fatimata Bintou Sall, Amadou Seck, Isaac Akhenaton Manga, Ibrahima Marietou Mbaye, Mor Absa Loum, Baba Camara, Diatou Niang, Babacar Gueye, Doudou Sene, Ndeye M'backe Kane, Boubacar Diop, Awa Diouf, Ndeye Aida Gaye, Marie Pierre Diouf, Aminata Colle Lo, Brian Greenwood, Jean Louis A. Ndiaye
Summary: The integration of mass drug administration for helminths with seasonal malaria chemoprevention was found to be safe and feasible among children in Senegal. These findings support further evaluation of the integrated control model.
Article
Immunology
Sybil Tasker, Anna Wight O'Rourke, Anvar Suyundikov, Peta-Gay Jackson Booth, Stephan Bart, Vyjayanthi Krishnan, Jianfeng Zhang, Katie J. Anderson, Bertrand Georges, M. Scot Roberts
Summary: NasoVAX, a monovalent intranasal influenza vaccine, was well-tolerated and elicited robust influenza-specific systemic and mucosal immune responses, with comparable effectiveness to the approved Fluzone(R) influenza vaccine.
Article
Medicine, General & Internal
Ehsan Mostafavi, Sana Eybpoosh, Mohammad Karamouzian, Malahat Khalili, Saiedeh Haji-Maghsoudi, Mostafa Salehi-Vaziri, Ali Khamesipour, Tahmineh Jalali, Mehran Nakhaeizadeh, Hamid Sharifi, Yasaman Mansoori, Fariba Keramat, Samad Ghodrati, Mostafa Javanian, Delaram Doroud, Mir Davood Omrani, Hassan Asadi, Mohammad Hassan Pouriayevali, Roya Ghasemian, Hossein Farshidi, Morteza Pourahmad, Iman Ghasemzadeh, Leila Mounesan, Maryam Darvishian, Mohamad Reza Mirjalili, Maria Eugenia Toledo-Romani, Carmen Valenzuela-Silva, Vicente Verez-Bencomo, Mohammad Mehdi Gouya, Hamid Emadi-Koochak, Ali Akbar Haghdoost, Alireza Biglari
Summary: This article evaluates the efficacy and safety of FINLAY-FR-2 and FINLAY-FR-1A vaccines in the Iranian population. The results show that both vaccines have acceptable vaccine efficacy against COVID-19 infection and are safe to administer. Therefore, Soberana may be a choice for mass vaccination, especially in resource-limited settings.
Article
Immunology
Marie-Astrid Hoogerwerf, Jan Pieter R. Koopman, Jacqueline J. Janse, Marijke C. C. Langenberg, Roos van Schuijlenburg, Yvonne C. M. Kruize, Eric A. T. Brienen, Mikhael D. Manurung, Petra Verbeek-Menken, Martha T. van der Beek, Inge M. Westra, Pauline Meij, Leo G. Visser, Lisette van Lieshout, Sake J. de Vlas, Maria Yazdanbakhsh, Luc E. Coffeng, Meta Roestenberg
Summary: The study found that repeated infection with hookworm larvae increased egg counts, reduced relative variability in egg output, and did not aggravate adverse events.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Dermatology
Andrew Blauvelt, Mark G. Lebwohl, Tomotaka Mabuchi, Ann Leung, Alyssa Garrelts, Heidi Crane, Hany ElMaraghy, Himanshu Patel, Terri Ridenour, Kyoungah See, Gaia Gallo, Carle Paul
Summary: This study reports the efficacy and safety of the approved dose of IXE over 5 years. Patients receiving IXE every 2 weeks or every 4 weeks showed significant improvement in Psoriasis Area and Severity Index scores at week 264, with consistent safety profile.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martina Oneko, Laura C. Steinhardt, Reuben Yego, Ryan E. Wiegand, Phillip A. Swanson, K. C. Natasha, Dorcas Akach, Tony Sang, Julie R. Gutman, Elizabeth L. Nzuu, Allan Dungani, B. Kim Lee Sim, Paul Ndaya Oloo, Kephas Otieno, Dennis K. Bii, Peter F. Billingsley, Eric R. James, Simon Kariuki, Aaron M. Samuels, Said Jongo, Winnie Chebore, Salim Abdulla, Claudia Daubenberger, Maxmillian Mpina, David Styers, Gail E. Potter, Ginnie Abarbanell, Thomas L. Richie, Stephen L. Hoffman, Robert A. Seder
Summary: A trial of Plasmodium falciparum vaccine in infants in a high-transmission malaria setting in western Kenya showed good safety and tolerability, but no significant protection against P. falciparum infection at 6 months. There was a dose-dependent increase in antibody responses, while T cell responses were undetectable in all dose groups.
Article
Allergy
Salman Siddiqui, Sally E. Wenzel, Michael E. Bozik, Donald G. Archibald, Steven I. Dworetzky, James L. Mather, Randall Killingsworth, Natasha Ghearing, Justin T. Schwartz, Sergei I. Ochkur, Elizabeth A. Jacobsen, William W. Busse, Reynold A. Panettieri, Calman Prussin
Summary: This study evaluated the efficacy and safety of dexpramipexole in patients with eosinophilic asthma. The results showed that dexpramipexole significantly reduced blood and nasal eosinophil levels in patients and was well tolerated. Larger clinical trials are needed to further assess the clinical efficacy of dexpramipexole in asthma treatment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Neuroimaging
Rosalie McDonough, Johanna M. Ospel, Charles B. L. M. Majoie, Jeffrey L. Saver, Philip White, Diederik W. J. Dippel, Scott B. Brown, Andrew M. Demchuk, Tudor G. Jovin, Peter J. Mitchell, Serge Bracard, Bruce C. Campbell, Keith W. Muir, Michael D. Hill, Francis Guillemin, Mayank Goyal
Summary: This study examined the effect of pre-stroke functional levels on the outcome of endovascular therapy. The results showed that patients with mild pre-existing disability/symptoms had worse outcomes compared to those without disability. However, within the subgroup of patients with mild disability/symptoms, endovascular therapy still had a significant benefit.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Infectious Diseases
Enagnon Kazali Alidjinou, Julie Demaret, Benedicte Corroyer-Simovic, Fanny Vuotto, Sophie Miczek, Julien Labreuche, Anne Goffard, Jacques Trauet, Daniela Lupau, Arnaud Dendooven, Dominique Huvent-Grelle, Juliette Podvin, Daniel Dreuil, Karine Faure, Dominique Deplanque, Laurence Bocket, Alain Duhamel, Annie Sobaszek, Didier Hober, Michael Hisbergues, Francois Puisieux, Brigitte Autran, Yazdan Yazdanpanah, Myriam Labalette, Guillaume Lefevre
Summary: The study investigated the serum neutralizing activity and T cell response against BA.1 and BA.2 sublineages before and after the administration of the booster vaccine in healthcare workers. The results showed that a low neutralizing activity was observed before the booster dose, but significant increases in neutralizing antibodies against Delta, BA.1, and BA.2 were observed after 3 months. Participants with recent infection maintained stable neutralizing antibody levels against Delta and BA.2, and showed an increase in neutralizing antibodies against BA.1.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Dominique Deplanque, Christine Fetro, Antoine Ferry, Philippe Lechat, Terence Beghyn, Claude Bernard, Antoine Bernasconi, Hugues Bienayme, Celine Cougoule, Joanie Del Bano, Claire Demiot, Benedicte Lebrun-Vignes
Summary: The repurposing of existing drugs for new indications can address unmet therapeutic needs, especially in the context of rare diseases and emergencies. However, there are challenges in accessing the drug and its data during preclinical and clinical stages, and clinical results may not guarantee marketing authorization or patient care. The round table proposed recommendations to overcome these obstacles, including the establishment of a well-funded public-private partnership to provide individualized support for projects until marketing application.
Article
Multidisciplinary Sciences
Christine Durier, Laetitia Ninove, Maeva Lefebvre, Anne Radenne, Corinne Desaint, Jacques Ropers, Rebecca Bauer, Said Lebbah, Diane Carette, Marie Lachatre, Anne-Sophie Lecompte, Dominique Deplanque, Elisabeth Botelho-Nevers, Anne Conrad, Bertrand Dussol, Zoha Maakaroun-Vermesse, Giovanna Melica, Jean-Francois Nicolas, Renaud Verdon, Jacques Kiladjian, Paul Loubet, Catherine Schmidt-Mutter, Christian Duale, Severine Ansart, Stephane Priet, Axel Levier, Diana Molino, Louis-Victorien Vieillard, Beatrice Parfait, Jean-Daniel Lelievre, Eric Tartour, Xavier de Lamballerie, Odile Launay
Summary: The immune response generated by a COVID-19 vaccine booster against delta and omicron variants was evaluated in 65 adults (aged 65-84) shortly after receiving the first booster dose. The study showed an increase in SARS-CoV-2 neutralizing antibodies in individuals who had not been previously infected, regardless of age, while a smaller increase was observed in those who had been infected before receiving a single dose of the primary vaccine. It is important to note that the humoral response was only observed starting from the 5th day after the booster dose.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Hakim Hocini, Aurelie Wiedemann, Fabiola Blengio, Cecile Lefebvre, Minerva Cervantes-Gonzalez, Emile Foucat, Pascaline Tisserand, Mathieu Surenaud, Severin Coleon, Melanie Prague, Lydia Guillaumat, Corinne Krief, Craig Fenwick, Cedric Laouenan, Lila Bouadma, Jade Ghosn, Giuseppe Pantaleo, Rodolphe Thiebaut, Yves Levy, Laurent Abel, Amal Abrous, Claire Andrejak, Francois Angoulvant, Delphine Bachelet, Marie Bartoli, Sylvie Behilill, Marine Beluze, Krishna Bhavsar, Anissa Chair, Charlotte Charpentier, Leo Chenard, Catherine Chirouze, Sandrine Couffin-cadiergues, Camille Couffignal, Nathalie D. E. Castro, Marie-Pierre Debray, Dominique Deplanque, Diane Descamps, Alpha Diallo, Fernanda Dias D. A. Silva, Celine Dorival, Xavier Duval, Philippine Eloy, Vincent Enouf, Helene Esperou, Marina Esposito-farese, Manuel Etienne, Aline-Marie Florence, Alexandre Gaymard, Tristan Gigante, Morgane Gilg, Francois Goehringer, Jeremie Guedj, Ikram Houas, Isabelle Hoffmann, Jean-Sebastien Hulot, Salma Jaafoura, Simon Jamard, Ouifiya Kafif, Antoine Khalil, Nadhem Lafhej, Samira Laribi, Minh Le, Quentin LE. Hingrat, Soizic LE. Mestre, Sophie Letrou, Bruno Lina, Guillaume Lingas, Denis Malvy, France Mentre, Hugo Mouquet, Nadege Neant, Christelle Paul, Aurelie Papadopoulos, Ventzislava Petrov-sanchez, Gilles Peytavin, Valentine Piquard, Olivier Picone, Manuel Rosa-calatrava, Benedicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Coralie Tardivon, Jean-Francois Timsit, Sarah Tubiana, Sylvie Van Der Werf, Benoit Visseaux
Summary: This study investigated the immunological dysfunction underlying the persistence of symptoms in individuals after severe COVID-19 infection. The analysis of cytokines, cell phenotypes, antibodies, and gene expression profiles revealed persistent abnormalities even up to 6 months after hospital discharge, including high levels of activation markers, T-cell abnormalities, decreased antibodies, and upregulation of genes related to blood components. These findings suggest the need for extended clinical follow-up and preventive measures for patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Dominique Deplanque
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Urology & Nephrology
Marina Wainstein, Nicholas Spyrison, Danyang Dai, Moji Ghadimi, Jonathan S. Chavez-Iniguez, Lilia Rizo-Topete, Barbara Wanjiru Citarella, Laura Merson, Jason D. Pole, Rolando Claure-Del Granado, David W. Johnson, S. Shrapnel
Summary: There is a lack of research on the relationship between COVID-19 and acute kidney injury (AKI) in low- and low-middle income countries. This study found that AKI incidence was highest in LLMIC, with lower rates of dialysis and poorer patient outcomes.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Nutrition & Dietetics
Lea Chantal Tran, Lucie Marousez, Marie De Lamballerie, Scott McCulloch, Emmanuel Hermann, Frederic Gottrand, Delphine Ley, Jean Lesage
Summary: The composition of the milk metabolome can be affected by different sterilization methods. High pressure sterilization has a greater impact on lipid compounds compared to pasteurization.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Tatiana Galperine, Ilka Engelmann, Sebastien Hantz, Deiborah Postil, Anny Dewilde, Dominique Deplanque, Renaud Martin, Julien Labreuche, Mouna Lazrek, Stephanie Somers, Elodie Ribot, Sophie Alain
Summary: Fecal Microbiota Transplantation (FMT) is the preferred treatment for recurrent Clostridioides difficile Infections (CDI). However, the donor screening process varies between countries and guidelines differ on the need for CMV testing. This study found that healthy donors with positive CMV serology do not shed CMV DNA in their stool, suggesting that CMV screening may not be necessary.
Article
Medicine, General & Internal
Florent Sauve, Sreekala Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coelho, Julie Dewisme, Edouard G. Mills, Gaetan Ternier, Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereno-Orbea, Maria Mercado-Gomez, Asis Palazon, Virginie Mattot, Florence Pasquier, Sophie Catteau-Jonard, Maria Martinez-Chantar, Erik Hrabovszky, Merce Jourdain, Dominique Deplanque, Annamaria Morelli, Giulia Guarnieri, Laurent Storme, Cyril Robil, Francois Trottein, Ruben Nogueiras, Markus Schwaninger, Pascal Pigny, Julien Poissy, Konstantina Chachlaki, Claude-Alain Maurage, Paolo Giacobini, Waljit Dhillo, S. Rasika, Vincent Prevot
Summary: There may be a connection between post-COVID symptoms and the loss of GnRH, which could lead to cognitive decline and other neurological symptoms. Research suggests that the decrease in testosterone levels in some COVID-19 patients may originate from the hypothalamus and be associated with cognitive or neurological symptoms. Infection of the olfactory sensory neurons and hypothalamic glia by the SARS-CoV-2 virus could result in abnormalities of the GnRH system. Furthermore, fetal olfactory and GnRH neurons may be susceptible to viral infection.
Article
Microbiology
Amilcar Flores, Cristina Alonso-Vega, Emmanuel Hermann, Mary-Cruz Torrico, Nair Alaide Montano Villarroel, Faustino Torrico, Yves Carlier, Carine Truyens
Summary: Monocytes from newborns born to Trypanosoma cruzi infected mothers are more activated and capable of controlling T. cruzi infection better than monocytes from newborns born to uninfected mothers.
Article
Multidisciplinary Sciences
Danye Lee, Jeremie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, Masato Ogishi, Remi Pescarmona, Estelle Talouarn, Darawan Rinchai, Peng Zhang, Magali Perret, Zhiyong Liu, Iolanda Jordan, Sefika Elmas Bozdemir, Gulsum Iclal Bayhan, Camille Beaufils, Lucy Bizien, Aurelie Bisiaux, Weite Lei, Milena Hasan, Jie Chen, Christina Gaughan, Abhishek Asthana, Valentina Libri, Joseph M. Luna, Fabrice Jaffre, H. -Heinrich Hoffmann, Eleftherios Michailidis, Marion Moreews, Yoann Seeleuthner, Kaya Bilguvar, Shrikant Mane, Carlos Flores, Yu Zhang, Andres A. Arias, Rasheed Bailey, Agatha Schlueter, Baptiste Milisavljevic, Benedetta Bigio, Tom Le Voyer, Marie Materna, Adrian Gervais, Marcela Moncada-Velez, Francesca Pala, Tomi Lazarov, Romain Levy, Anna-Lena Neehus, Jeremie Rosain, Jessica Peel, Yi-Hao Chan, Marie-Paule Morin, Rosa Maria Pino-Ramirez, Serkan Belkaya, Lazaro Lorenzo, Jordi Anton, Selket Delafontaine, Julie Toubiana, Fanny Bajolle, Victoria Furnado, Marta L. DeDiego, Nadhira Fidouh, Flore Rozenberg, Jordi Perez-Tur, Shuibing Chen, Todd Evans, Frederic Geissmann, Pierre Lebon, Susan R. Weiss, Damien Bonnet, Xavier Duval, Qiang Pan-Hammarstroem, Anna M. Planas, Isabelle Meyts, Filomeen Haerynck, Aurora Pujol, Vanessa Sancho-Shimizu, Clifford L. Dalgard, Jacinta Bustamante, Anne Puel, Stephanie Boisson-Dupuis, Bertrand Boisson, Tom Maniatis, Qian Zhang, Paul Bastard, Luigi Notarangelo, Vivien Beziat, Rebeca Perez de Diego, Carlos Rodriguez-Gallego, Helen C. Su, Richard P. Lifton, Emmanuelle Jouanguy, Aurelie Cobat, Laia Alsina, Sevgi Keles, Elie Haddad, Laurent Abel, Alexandre Belot, Lluis Quintana-Murci, Charles M. Rice, Robert H. Silverman, Shen-Ying Zhang, Jean-Laurent Casanova
Article
Gastroenterology & Hepatology
Alexandre Louvet, Julien Labreuche, Christophe Moreno, Claire Vanlemmens, Romain Moirand, Cyrille Feray, Jerome Dumortier, Georges-Philippe Pageaux, Christophe Bureau, Faiza Chermak, Christophe Duvoux, Dominique Thabut, Vincent Leroy, Nicolas Carbonell, Benjamin Rolland, Ephrem Salame, Rodolphe Anty, Jerome Gournay, Jean Delwaide, Christine Silvain, Valerio Lucidi, Guillaume Lassailly, Sebastien Dharancy, Eric Nguyen-Khac, Didier Samuel, Alain Duhamel, Philippe Mathurin
Summary: This study compared the effectiveness of early liver transplantation and standard liver transplantation in patients with alcohol-related hepatitis. The study found that early liver transplantation did not reduce the rate of alcohol relapse, but it improved the survival rate of patients. High alcohol intake was more common after early liver transplantation.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)