Harnessing the Helminth Secretome for Therapeutic Immunomodulators

Protective Mechanisms of Helminths Against Reactive Oxygen Species are Highly Promising Drug Targets

(2014) Markus Perbandt et al.   CURRENT MEDICINAL CHEMISTRY

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

(2014) C. Schnoeller et al.   JOURNAL OF IMMUNOLOGY

Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs

(2014) Dolores Bernal et al.   Journal of Proteomics

Proteomic analysis of the tegument and excretory–secretory products of Dicrocoelium dendriticum (Digenea) adult worms

(2013) A.M. Martínez-Ibeas et al.   EXPERIMENTAL PARASITOLOGY

Helminth-excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway

(2013) César A. Terrazas et al.   FASEB JOURNAL

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

(2013) Ivana Ferreira et al.   INFECTION AND IMMUNITY

Helminth therapies: Translating the unknown unknowns to known knowns

(2013) Adnan R. Khan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Prerequisites for the pharmaceutical industry to develop and commercialise helminths and helminth-derived product therapy

(2013) Cornelia Tilp et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Secretome Analysis of the Pine Wood Nematode Bursaphelenchus xylophilus Reveals the Tangled Roots of Parasitism and Its Potential for Molecular Mimicry

(2013) Ryoji Shinya et al.   PLoS One

Helminths and Immunological Tolerance

(2013) Chris J.C. Johnston et al.   TRANSPLANTATION

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

(2013) John P. Dalton et al.   VETERINARY PARASITOLOGY

Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity

(2013) James P. Hewitson et al.   PLoS Pathogens

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

(2013) Erich M Schwarz et al.   GENOME BIOLOGY

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?

(2013) Marc P. Hübner et al.   Pathogens and Disease

Glycoconjugates in Host-Helminth Interactions

(2013) Nina Salinger Prasanphanich et al.   Frontiers in Immunology

Reflex Principles of Immunological Homeostasis

(2012) Ulf Andersson et al.   Annual Review of Immunology

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Where are we on worms?

(2012) David E. Elliott et al.   CURRENT OPINION IN GASTROENTEROLOGY

The hookworm pharmacopoeia for inflammatory diseases

(2012) Severine Navarro et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Translatability of helminth therapy in inflammatory bowel diseases

(2012) Joel V. Weinstock et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth infection is associated with decreased basophil responsiveness in human beings

(2012) David Larson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic Helminth Infection Reduces Basophil Responsiveness in an IL-10-Dependent Manner

(2012) D. Larson et al.   JOURNAL OF IMMUNOLOGY

The worm returns

(2012) Joel V. Weinstock   NATURE

Trichinella spiralis-secreted products modulate DC functionality and expand regulatory T cells in vitro

(2012) C. ARANZAMENDI et al.   PARASITE IMMUNOLOGY

First analysis of the secretome of the canine heartworm, Dirofilaria immitis

(2012) James Geary et al.   Parasites & Vectors

Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

(2012) Antonio Marcilla et al.   PLoS One

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

New Paradigms in Type 2 Immunity

(2012) B. Pulendran et al.   SCIENCE

Immunopathogenesis of lymphatic filarial disease

(2012) Subash Babu et al.   Seminars in Immunopathology

How helminths use excretory secretory fractions to modulate dendritic cells

(2012) Rhiannon R. White et al.   Virulence

Chronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection

(2012) Marc P. Hübner et al.   PLoS Neglected Tropical Diseases

In silico secretome analysis approach for next generation sequencing transcriptomic data

(2011) Gagan Garg et al.   BMC GENOMICS

Parasitic worm therapy for allergy: Is this incongruous or avant-garde medicine?

(2011) D. I. Pritchard et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Protective Effect of the Recombinant 53-kDa Protein of Trichinella spiralis on Experimental Colitis in Mice

(2011) Linlin Du et al.   DIGESTIVE DISEASES AND SCIENCES

Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

(2011) Guilherme Grossi Lopes Cançado et al.   INFLAMMATORY BOWEL DISEASES

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Reconstitution of the human biome as the most reasonable solution for epidemics of allergic and autoimmune diseases

(2011) Staci D. Bilbo et al.   MEDICAL HYPOTHESES

Life Cycle Stage-resolved Proteomic Analysis of the Excretome/Secretome fromStrongyloides ratti—Identification of Stage-specific Proteases

(2011) Hanns Soblik et al.   MOLECULAR & CELLULAR PROTEOMICS

Ascaris suum draft genome

(2011) Aaron R. Jex et al.   NATURE

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation

(2010) T. Adjobimey et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

(2010) Hermelijn H. Smits et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Worms to the rescue: Can worm glycans protect from autoimmune diseases?

(2010) Loes M. Kuijk et al.   IUBMB LIFE

Dendritic Cells in the Gut: Interaction with Intestinal Helminths

(2010) Fela Mendlovic et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Immune Modulation bySchistosoma mansoniAntigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems

(2010) Paola Zaccone et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PAS-1, an Ascaris suum Protein, Modulates Allergic Airway Inflammation via CD8+ γδTCR+ and CD4+ CD25+ FoxP3+ T Cells

(2010) C. A. A. De Araújo et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages

(2009) Lidia Prieto-Lafuente et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth PathogenFasciola hepatica

(2009) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Immunomodulation by phosphocholine—Biosynthesis, structures and immunological implications of parasitic PC-epitopes

(2009) Julia Grabitzki et al.   MOLECULAR IMMUNOLOGY

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

(2009) Georgina S. Butler et al.   NATURE REVIEWS DRUG DISCOVERY

Immunological Interactions between 2 Common Pathogens, Th1-Inducing Protozoan Toxoplasma gondii and the Th2-Inducing Helminth Fasciola hepatica

(2009) Catherine M. D. Miller et al.   PLoS One

Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?

(2009) Klaus J. Erb   TRENDS IN IMMUNOLOGY

Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling

(2009) Sasisekhar Bennuru et al.   PLoS Neglected Tropical Diseases

The secretory omega-class glutathione transferase OvGST3 from the human pathogenic parasite Onchocerca volvulus

(2008) Eva Liebau et al.   FEBS Journal

Review series on helminths, immune modulation and the hygiene hypothesis: Nematode coevolution with adaptive immunity, regulatory networks and the growth of inflammatory diseases

(2008) Daniel M. Altmann   IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: How might infection modulate the onset of type 1 diabetes?

(2008) Anne Cooke   IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function

(2008) Lucas Carvalho et al.   IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

(2008) Graham A. W. Rook   IMMUNOLOGY

Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+regulatory T cells

(2008) Marc P. Hübner et al.   IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: Immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?

(2008) Joseph A. Jackson et al.   IMMUNOLOGY

Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice

(2008) Nathalie E. Ruyssers et al.   INFLAMMATORY BOWEL DISEASES

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm,Ancylostoma caninum

(2008) Jason Mulvenna et al.   MOLECULAR & CELLULAR PROTEOMICS

Excretory–secretory products of larval Fasciola hepatica investigated using a two-dimensional proteomic approach

(2008) Benjamin E.F. Gourbal et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The secretome of the filarial parasite, Brugia malayi: Proteomic profile of adult excretory–secretory products

(2008) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A

(2008) Justyna Rzepecka et al.   MOLECULAR IMMUNOLOGY

Proteomic analysis of excretory/secretory products released byTeladorsagia circumcinctalarvae early post-infection

(2008) S. K. SMITH et al.   PARASITE IMMUNOLOGY

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules

(2008) M. J. G. JOHNSTON et al.   PARASITOLOGY

Helminth infections and intestinal inflammation

(2008) Li Jian Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Proteomic Analysis of Skin Invasion by Blood Fluke Larvae

(2008) Elizabeth Hansell et al.   PLoS Neglected Tropical Diseases

Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

(2008) Yovany Moreno et al.   PLoS Neglected Tropical Diseases

Direct Identification of the Meloidogyne incognita Secretome Reveals Proteins with Host Cell Reprogramming Potential

(2008) Stéphane Bellafiore et al.   PLoS Pathogens

Interplay of parasite-driven immune responses and autoimmunity

(2007) Paola Zaccone et al.   TRENDS IN PARASITOLOGY