Knockdown of miRNA-134-5p rescues dendritic deficits by promoting AMPK-mediated mitophagy in a mouse model of depression

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue

(2021) Cheoljun Choi et al.   DIABETES

R (−)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine

(2021) Chrislean Jun Botanas et al.   NEUROPHARMACOLOGY

Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat

(2021) Ye Li et al.   NEUROPHARMACOLOGY

Mitophagy in depression: Pathophysiology and treatment targets

(2021) Ashutosh Tripathi et al.   MITOCHONDRION

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

(2020) Alex P. Seabright et al.   FASEB JOURNAL

Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus

(2020) Zhujin Song et al.   NEUROPHARMACOLOGY

The Stage of the Estrus Cycle Is Critical for Interpretation of Female Mouse Social Interaction Behavior

(2020) Trishala Chari et al.   Frontiers in Behavioral Neuroscience

Molecular correlates of mitochondrial dysfunctions in major depression: Evidence from clinical and rodent studies

(2020) Virginie Rappeneau et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor α-deficient female mice via BDNF-AKT/ERK1/2 signaling

(2020) Guoli Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

(2019) Nan Yao et al.   Cell Death & Disease

Plasticity of dendritic spines: Molecular function and dysfunction in neurodevelopmental disorders

(2019) Jun Nishiyama   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF–Trkb–CREB Pathway

(2019) Guoli Wang et al.   Frontiers in Pharmacology

The protective effort of GPCR kinase 2–interacting protein‐1 in neurons via promoting Beclin1‐Parkin induced mitophagy at the early stage of spinal cord ischemia‐reperfusion injury

(2019) Yi‐Fan Huang et al.   FASEB JOURNAL

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice

(2018) Jingqi Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

(2016) Chen-Song Zhang et al.   Cell Metabolism

Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

(2016) Andreas Mæchel Fritzen et al.   CELLULAR SIGNALLING

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Location-dependent synaptic plasticity rules by dendritic spine cooperativity

(2016) Jens P. Weber et al.   Nature Communications

Dendritic Spines in Depression: What We Learned from Animal Models

(2016) Hui Qiao et al.   NEURAL PLASTICITY

Emerging role of synaptic actin-regulatory pathway in the pathophysiology of mood disorders

(2015) Su-Yeon Choi et al.   Animal Cells and Systems

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Spine synapse remodeling in the pathophysiology and treatment of depression

(2015) Catharine H. Duman et al.   NEUROSCIENCE LETTERS

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

(2015) Xue-Yu Fan et al.   Scientific Reports

BECN1 is involved in the initiation of mitophagy

(2014) Vinay Choubey et al.   Autophagy

MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression

(2014) R. Fiore et al.   EMBO JOURNAL

Omega-3 polyunsaturated fatty acids and chronic stress-induced modulations of glutamatergic neurotransmission in the hippocampus

(2014) Marie Hennebelle et al.   NUTRITION REVIEWS

Hippocampus Atrophy and the Longitudinal Course of Late-life Depression

(2013) Warren D. Taylor et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

ULK1 targets Beclin-1 in autophagy

(2013) Volodymyr Y. Nazarko et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls

(2012) Kathryn Sawyer et al.   AGING & MENTAL HEALTH

Mitochondrial Alterations and Neuropsychiatric Disorders

(2012) D. Marazziti et al.   CURRENT MEDICINAL CHEMISTRY

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

MicroRNA networks direct neuronal development and plasticity

(2011) N. F. M. Olde Loohuis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Activity-Dependent Dendritic Release of BDNF and Biological Consequences

(2009) Nicola Kuczewski et al.   MOLECULAR NEUROBIOLOGY

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

(2009) Gabriele Siegel et al.   NATURE CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY