Molecular correlates of mitochondrial dysfunctions in major depression: Evidence from clinical and rodent studies

Proteomic Profiling as a Diagnostic Biomarker for Discriminating Between Bipolar and Unipolar Depression

(2020) Sarah Kittel-Schneider et al.   Frontiers in Psychiatry

Social isolation stress-resilient rats reveal energy shift from glycolysis to oxidative phosphorylation in hippocampal nonsynaptic mitochondria

(2020) Dragana Filipović et al.   LIFE SCIENCES

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

(2020) Christina A. Castellani et al.   MITOCHONDRION

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Environmental Programming of Susceptibility and Resilience to Stress in Adulthood in Male Mice

(2019) Catherine Jensen Peña et al.   Frontiers in Behavioral Neuroscience

Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder

(2019) Noa Tsujii et al.   Frontiers in Psychiatry

Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior

(2019) Zuzanna Misiewicz et al.   PLoS Genetics

Investigation of mitochondrial DNA copy number in patients with major depressive disorder

(2019) Jae Kyung Chung et al.   PSYCHIATRY RESEARCH

Multiple trial inhibitory avoidance acquisition and retrieval are resistant to chronic stress

(2018) J. Raya et al.   BEHAVIOURAL PROCESSES

Mitochondrial Etiology of Neuropsychiatric Disorders

(2018) Liming Pei et al.   BIOLOGICAL PSYCHIATRY

Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder

(2018) Enzo Scifo et al.   BIOLOGICAL PSYCHIATRY

Differential mitochondrial DNA copy number in three mood states of bipolar disorder

(2018) Dong Wang et al.   BMC Psychiatry

Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly

(2018) Gregory J. Tranah et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression

(2018) Olga Tymofiyeva et al.   JOURNAL OF AFFECTIVE DISORDERS

The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression

(2018) Yuki Kageyama et al.   JOURNAL OF AFFECTIVE DISORDERS

Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review

(2018) Mario F. Juruena et al.   JOURNAL OF AFFECTIVE DISORDERS

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

(2018) Joram D Mul   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

(2018) Daniel Lindqvist et al.   NEUROPSYCHOPHARMACOLOGY

Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors

(2018) Hannah E. Lapp et al.   NEUROTOXICOLOGY AND TERATOLOGY

Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment

(2018) Katarzyna Głombik et al.   Pharmacological Reports

Cardiac oxidative stress following maternal separation stress was mitigated following adolescent voluntary exercise in adult male rat

(2018) Ehtramolsadat Sahafi et al.   PHYSIOLOGY & BEHAVIOR

Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts

(2018) Magdalena Sowa-Kućma et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Psychological Stress and Mitochondria

(2018) Martin Picard et al.   PSYCHOSOMATIC MEDICINE

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

(2018) Kathryn K. Ridout et al.   BIOESSAYS

Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise

(2018) Laura Micheli et al.   BRAIN RESEARCH BULLETIN

Stress and glucocorticoid receptor regulation of mitochondrial gene expression

(2018) Hannah E. Lapp et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

(2018) Ashley L. Heck et al.   NEUROPSYCHOPHARMACOLOGY

Identification of depression subtypes and relevant brain regions using a data-driven approach

(2018) Tomoki Tokuda et al.   Scientific Reports

MITOCHONDRIA, METABOLISM AND REDOX MECHANISMS IN PSYCHIATRIC DISORDERS

(2018) Yeni Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology

(2018) Emily L. Belleau et al.   BIOLOGICAL PSYCHIATRY

Mitochondrial genetic medicine

(2018) Douglas C. Wallace   NATURE GENETICS

iTRAQ-Based Quantitative Proteomics Suggests Synaptic Mitochondrial Dysfunction in the Hippocampus of Rats Susceptible to Chronic Mild Stress

(2018) Hong Xie et al.   NEUROCHEMICAL RESEARCH

The Mitochondrion as Potential Interface in Early-Life Stress Brain Programming

(2018) Anke Hoffmann et al.   Frontiers in Behavioral Neuroscience

Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression

(2018) Hayato Akimoto et al.   BEHAVIOURAL BRAIN RESEARCH

Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines

(2017) Ivana Perić et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Moving forward: how depression heterogeneity hinders progress in treatment and research

(2017) EI Fried   Expert Review of Neurotherapeutics

Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1

(2017) Masakazu Ibi et al.   JOURNAL OF NEUROSCIENCE

Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids

(2017) Jaewoo Choi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study

(2017) J E Verhoeven et al.   MOLECULAR PSYCHIATRY

Mitochondrial energy metabolism of rat hippocampus after treatment with the antidepressants desipramine and fluoxetine

(2017) Roberto Federico Villa et al.   NEUROPHARMACOLOGY

Prefrontal cortical glutathione-dependent defense and proinflammatory mediators in chronically isolated rats: Modulation by fluoxetine or clozapine

(2017) Nevena Todorović et al.   NEUROSCIENCE

Reconsidering depression as a risk factor for substance use disorder: Insights from rodent models

(2017) Virginie Rappeneau et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia

(2017) Magdalena Sowa-Kućma et al.   NEUROTOXICITY RESEARCH

Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria – A proteomic study in an animal model of depression

(2017) Katarzyna Głombik et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Sex-dependent mental illnesses and mitochondria

(2017) Akiko Shimamoto et al.   SCHIZOPHRENIA RESEARCH

Neurobiology of depression: A neurodevelopmental approach

(2017) Juan M. Lima-Ojeda et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity

(2017) Silja McIlwrick et al.   Frontiers in Cellular Neuroscience

Aberrant telomere length and mitochondrial DNA copy number in suicide completers

(2017) Ikuo Otsuka et al.   Scientific Reports

Moving forward: how depression heterogeneity hinders progress in treatment and research

(2017) EI Fried   Expert Review of Neurotherapeutics

Gene—Environment Interactions in Major Depressive Disorder

(2017) Torsten Klengel et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Imaging Adenosine Triphosphate (ATP)

(2016) Megha Rajendran et al.   BIOLOGICAL BULLETIN

The Amount of Mitochondrial DNA in Blood Reflects the Course of a Depressive Episode

(2016) Jérôme Nicod et al.   BIOLOGICAL PSYCHIATRY

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

(2016) Audrey R. Tyrka et al.   BIOLOGICAL PSYCHIATRY

The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression

(2016) Aneta Stachowicz et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System

(2016) Vyara Todorova et al.   Current Neuropharmacology

Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders

(2016) Miroslav Adzic et al.   DRUG DEVELOPMENT RESEARCH

Early Stress History Alters Serum Insulin-Like Growth Factor-1 and Impairs Muscle Mitochondrial Function in Adult Male Rats

(2016) S. Ghosh et al.   JOURNAL OF NEUROENDOCRINOLOGY

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress

(2016) Christina Boeck et al.   MITOCHONDRION

Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder

(2016) Marcin Siwek et al.   MOLECULAR NEUROBIOLOGY

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

(2016) S P Pantazatos et al.   MOLECULAR PSYCHIATRY

Effect of desipramine and fluoxetine on energy metabolism of cerebral mitochondria

(2016) Roberto Federico Villa et al.   NEUROSCIENCE

The impact of childhood maltreatment on redox state: Relationship with oxidative damage and antioxidant defenses in adolescents with no psychiatric disorder

(2016) Carine Hartmann do Prado et al.   NEUROSCIENCE LETTERS

Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts

(2016) Yamilee Hurtado-Roca et al.   PLoS One

Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder

(2016) Meng-Chang Tsai et al.   PSYCHIATRY RESEARCH

Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort

(2016) C. N. Black et al.   PSYCHOLOGICAL MEDICINE

Genetic predisposition for high stress reactivity amplifies effects of early-life adversity

(2016) Silja McIlwrick et al.   PSYCHONEUROENDOCRINOLOGY

Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder

(2016) Qingzhong Wang et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine

(2016) Nazanin Sonei et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity

(2016) D Lindqvist et al.   Translational Psychiatry

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus

(2015) Yuan Shao et al.   BEHAVIOURAL BRAIN RESEARCH

How many different ways do patients meet the diagnostic criteria for major depressive disorder?

(2015) Mark Zimmerman et al.   COMPREHENSIVE PSYCHIATRY

Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder

(2015) Na Cai et al.   CURRENT BIOLOGY

Molecular Signatures of Major Depression

(2015) Na Cai et al.   CURRENT BIOLOGY

Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study

(2015) Eiko I. Fried et al.   JOURNAL OF AFFECTIVE DISORDERS

Divergent Urinary Metabolic Phenotypes between Major Depressive Disorder and Bipolar Disorder Identified by a Combined GC–MS and NMR Spectroscopic Metabonomic Approach

(2015) Jian-jun Chen et al.   JOURNAL OF PROTEOME RESEARCH

Synaptic mitochondria: A brain mitochondria cluster with a specific proteome

(2015) Katalin Völgyi et al.   Journal of Proteomics

Behavioural and biochemical changes in maternally separated Sprague–Dawley rats exposed to restraint stress

(2015) P. J. van Zyl et al.   METABOLIC BRAIN DISEASE

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis

(2015) Sarah E Daniel et al.   NEUROPSYCHOPHARMACOLOGY

Stress Effects on Neuronal Structure: Hippocampus, Amygdala and Prefrontal Cortex

(2015) Bruce S McEwen et al.   NEUROPSYCHOPHARMACOLOGY

Which instruments to support diagnosis of depression have sufficient accuracy? A systematic review

(2015) Agneta Pettersson et al.   NORDIC JOURNAL OF PSYCHIATRY

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

(2015) Magdaléna Vaváková et al.   Oxidative Medicine and Cellular Longevity

Biochemical markers subtyping major depressive disorder

(2015) Hiroshi Kunugi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats

(2015) Katarzyna Głombik et al.   PSYCHONEUROENDOCRINOLOGY

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA

(2015) Vinai C. Bhagirath et al.   SHOCK

Mitochondrial Mutations in Subjects with Psychiatric Disorders

(2015) Adolfo Sequeira et al.   PLoS One

Comparison of pro-inflammatory cytokines among patients with bipolar disorder and unipolar depression and normal controls

(2014) Ya-Mei Bai et al.   BIPOLAR DISORDERS

The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder

(2014) Karim Malki et al.   BMC Medicine

Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies

(2014) Liang Su et al.   BMC Psychiatry

Sex differences in animal models of psychiatric disorders

(2014) N Kokras et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches

(2014) Fabian Sanchis-Gomar et al.   CURRENT PHARMACEUTICAL DESIGN

A mitochondrial bioenergetic basis of depression

(2014) N. Jennifer Klinedinst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids

(2014) Martin Picard et al.   Nature Reviews Endocrinology

Oxidative & nitrosative stress in depression: Why so much stress?

(2014) Steven Moylan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence

(2014) Yash B. Joshi et al.   Oxidative Medicine and Cellular Longevity

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment

(2014) Piotr Gałecki et al.   Pharmacological Reports

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls–preliminary findings

(2014) Daniel Lindqvist et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: A translational approach

(2014) Jan-Michael Heinzmann et al.   PSYCHONEUROENDOCRINOLOGY

Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: Gene expression profiles, MtDNA content and presence of the MtDNA common deletion

(2013) Helena Torrell et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

(2013) Joanna Rybka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of Hsp70i against chronic social isolation stress in the rat hippocampus

(2013) Jelena Zlatković et al.   JOURNAL OF NEURAL TRANSMISSION

Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats

(2013) Milos Mitic et al.   NEUROPHARMACOLOGY

Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model

(2013) Helena M. Abelaira et al.   NEUROSCIENCE RESEARCH

Lipid Peroxidation and Depressed Mood in Community-Dwelling Older Men and Women

(2013) Yuri Milaneschi et al.   PLoS One

Glucocorticoids and their receptors: Insights into specific roles in mitochondria

(2013) Sung-Ryul Lee et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

(2013) Adrian L. Lopresti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Association between erythrocyte n-3 polyunsaturated fatty acids and biomarkers of inflammation and oxidative stress in patients with and without depression

(2013) Dawon Baek et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: Effects on energy metabolism

(2013) Miroslav Adzic et al.   PSYCHONEUROENDOCRINOLOGY

Depression and Oxidative Stress

(2013) Priya Palta et al.   PSYCHOSOMATIC MEDICINE

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Lower CSF Amyloid Beta Peptides and Higher F2-Isoprostanes in Cognitively Intact Elderly Individuals With Major Depressive Disorder

(2012) Nunzio Pomara et al.   AMERICAN JOURNAL OF PSYCHIATRY

Data-driven subtypes of major depressive disorder: a systematic review

(2012) Hanna M van Loo et al.   BMC Medicine

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine

(2012) Marisa Möller et al.   BRAIN BEHAVIOR AND IMMUNITY

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function

(2012) Daniel Martins-de-Souza et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism

(2012) Alana Knapman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex

(2012) Ana Djordjevic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The relevance of oxidative stress status in first episode and recurrent depression

(2012) Cristinel Stefanescu et al.   JOURNAL OF AFFECTIVE DISORDERS

From Sirtuin Biology to Human Diseases: An Update

(2012) Carlos Sebastián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Psychiatric Manifestations of Mitochondrial Disorders

(2012) Rebecca E. Anglin et al.   JOURNAL OF CLINICAL PSYCHIATRY

NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice

(2012) J.-S. Seo et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress and glutathione response in tissue cultures from persons with major depression

(2012) Sara A. Gibson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

Synergist effects of n-acetylcysteine and deferoxamine treatment on behavioral and oxidative parameters induced by chronic mild stress in rats

(2012) Camila O. Arent et al.   NEUROCHEMISTRY INTERNATIONAL

Bax and B-cell-lymphoma 2 mediate proapoptotic signaling following chronic isolation stress in rat brain

(2012) J. ZLATKOVIĆ et al.   NEUROSCIENCE

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

(2012) Guilherme A. Behr et al.   Oxidative Medicine and Cellular Longevity

Tianeptine exerts neuroprotective effects in the brain tissue of rats exposed to the chronic stress model

(2012) Franciela P. Della et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Increased oxidative stress in patients with depression and its relationship to treatment

(2012) Cecilia P. Chung et al.   PSYCHIATRY RESEARCH

Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning

(2012) Weina Liu et al.   PSYCHONEUROENDOCRINOLOGY

Neonatal handling prevents anxiety-like symptoms in rats exposed to chronic mild stress: Behavioral and oxidative parameters

(2012) Nardeli Boufleur et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress

(2012) Sam W. Chan et al.   Biomed Research International

Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients

(2012) D Martins-de-Souza et al.   Translational Psychiatry

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study

(2011) Cheng-Ta Li et al.   BRITISH JOURNAL OF PSYCHIATRY

A COMPARISON OF MELANCHOLIC AND NONMELANCHOLIC RECURRENT MAJOR DEPRESSION IN HAN CHINESE WOMEN

(2011) Ning Sun et al.   DEPRESSION AND ANXIETY

Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study

(2011) Pedro V. S. Magalhães et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Chronic isolation stress predisposes the frontal cortex but not the hippocampus to the potentially detrimental release of cytochrome c from mitochondria and the activation of caspase-3

(2011) D. Filipović et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress

(2011) Morgana Moretti et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

Stress-induced alternations in CuZnSOD and MnSOD activity in cellular compartments of rat liver

(2011) Jelena Zlatković et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of Octreotide in Chronically Mild Stressed Rats: Possible Role of Immune and Oxidative Stress Pathways

(2011) Mona F. Schaalan et al.   NEUROCHEMICAL RESEARCH

Increased apoptosis and different regulation of pro-apoptosis protein bax and anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression

(2011) Deyu Yang et al.   NEUROSCIENCE LETTERS

Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects

(2011) Esther Nederhof et al.   PHYSIOLOGY & BEHAVIOR

Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

(2011) Vahap Ozan Kotan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats

(2011) Ana Djordjevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

(2010) Moo-Young Kim et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

(2010) Marisa Möller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

(2010) Jeremy W. Gawryluk et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

Oxidative stress in anxiety and comorbid disorders

(2010) Iiris Hovatta et al.   NEUROSCIENCE RESEARCH

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

(2010) Ann Gardner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression and oxidative damage to lipids

(2010) Sarah Yager et al.   PSYCHONEUROENDOCRINOLOGY

Overview of the Genetics of Major Depressive Disorder

(2010) Falk W. Lohoff   Current Psychiatry Reports

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

(2009) Stefania Schiavone et al.   BIOLOGICAL PSYCHIATRY

Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress

(2009) Gislaine T. Rezin et al.   BRAIN RESEARCH BULLETIN

Antioxidative enzymes and increased oxidative stress in depressive women

(2009) Jana Kodydková et al.   CLINICAL BIOCHEMISTRY

The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats

(2009) Miroslav Adzic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Antidepressant effect of Shudihuang on mice exposed to unpredictable chronic mild stress

(2009) Di Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Number matters: control of mammalian mitochondrial DNA copy number

(2009) Laura L. Clay Montier et al.   Journal of Genetics and Genomics

Chronic social isolation is related to both upregulation of plasticity genes and initiation of proapoptotic signaling in Wistar rat hippocampus

(2009) Ana Djordjevic et al.   JOURNAL OF NEURAL TRANSMISSION

Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice

(2009) M.L. Palumbo et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Effects of chronic mild stress on the oxidative parameters in the rat brain

(2009) Giancarlo Lucca et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2009) Brandi Rollins et al.   PLoS One

Rhythmicity in Mice Selected for Extremes in Stress Reactivity: Behavioural, Endocrine and Sleep Changes Resembling Endophenotypes of Major Depression

(2009) Chadi Touma et al.   PLoS One

Dynamic regulation of mitochondrial function by glucocorticoids

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial involvement in psychiatric disorders

(2008) Ling Shao et al.   ANNALS OF MEDICINE

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder

(2008) Dan V. Iosifescu et al.   BIOLOGICAL PSYCHIATRY

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

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Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm

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Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

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Mitochondria in Neuroplasticity and Neurological Disorders

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Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

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Mice selected for high versus low stress reactivity: A new animal model for affective disorders

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HPA axis and sleep: Identifying subtypes of major depression

(2008) Irina Antonijevic et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Platelet contamination causes large variation as well as overestimation of mitochondrial DNA content of peripheral blood mononuclear cells

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Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study

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