HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

(2020) Mark M. Pomerantz et al.   NATURE GENETICS

The DNA methylation landscape of advanced prostate cancer

(2020) Shuang G. Zhao et al.   NATURE GENETICS

MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

(2020) Calvin VanOpstall et al.   eLife

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

(2019) Michael A. Augello et al.   CANCER CELL

Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

(2019) Bohan Xu et al.   CELL RESEARCH

Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA

(2019) Shu Yi Shen et al.   Nature Protocols

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors

(2019) Parisa Mazrooei et al.   CANCER CELL

The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization

(2019) Yin Li et al.   Epigenetics & Chromatin

Genetics of lipid metabolism in prostate cancer

(2018) Ninu Poulose et al.   NATURE GENETICS

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

(2018) Jingjing Chen et al.   NATURE GENETICS

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

(2018) Zhong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

(2018) Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

(2018) Giorgia Zadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer

(2018) Dorhyun Johng et al.   PROSTATE

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

(2018) Ka-wing Fong et al.   Nature Communications

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer

(2017) W Han et al.   ONCOGENE

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics

(2017) Holly M. Nguyen et al.   PROSTATE

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

(2017) Timothy S. Heuer et al.   EBioMedicine

Androgen control of lipid metabolism in prostate cancer: novel insights and future applications

(2016) Lisa M Butler et al.   ENDOCRINE-RELATED CANCER

Gene regulatory mechanisms underpinning prostate cancer susceptibility

(2016) Thomas Whitington et al.   NATURE GENETICS

Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes

(2015) Z. Kote-Jarai et al.   ANNALS OF ONCOLOGY

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

(2015) Mark M Pomerantz et al.   NATURE GENETICS

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

(2015) Sándor Spisák et al.   NATURE MEDICINE

Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer

(2015) Anna Díez-Villanueva et al.   Epigenetics & Chromatin

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

(2015) Richard Ventura et al.   EBioMedicine

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

(2014) Qilai Huang et al.   NATURE GENETICS

Whole-Genome Methylation Sequencing Reveals Distinct Impact of Differential Methylations on Gene Transcription in Prostate Cancer

(2013) Yan P. Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Androgen Receptor-Independent Function of FoxA1 in Prostate Cancer Metastasis

(2013) H.-J. Jin et al.   CANCER RESEARCH

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

Target analysis by integration of transcriptome and ChIP-seq data with BETA

(2013) Su Wang et al.   Nature Protocols

Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo

(2013) Seo-Hee You et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Detection of Lipid-Rich Prostate Circulating Tumour Cells with Coherent Anti-Stokes Raman Scattering Microscopy

(2012) Ranjana Mitra et al.   BMC CANCER

Regulated Clearance of Histone Deacetylase 3 Protects Independent Formation of Nuclear Receptor Corepressor Complexes

(2012) Chun Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Germline Mutations inHOXB13and Prostate-Cancer Risk

(2012) Charles M. Ewing et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction

(2011) Hideyuki Takeshima et al.   GENOMICS

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

The role of histone deacetylases in prostate cancer

(2010) Ata Abbas et al.   Epigenetics

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

The Homeodomain Protein HOXB13 Regulates the Cellular Response to Androgens

(2009) John D. Norris et al.   MOLECULAR CELL

Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences

(2008) Michael F. Berger et al.   CELL

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

(2008) Sarah K Knutson et al.   EMBO JOURNAL