Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

Population-specific causal disease effect sizes in functionally important regions impacted by selection

(2021) Huwenbo Shi et al.   Nature Communications

The Heterogeneity of Mental Health Assessment

(2020) Jennifer J. Newson et al.   Frontiers in Psychiatry

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

(2020) Na Cai et al.   NATURE GENETICS

Multivariate genome-wide analyses of the well-being spectrum

(2019) Bart M. L. Baselmans et al.   NATURE GENETICS

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

(2019) Dongmei Yu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species

(2019) Margaux L.A. Hujoel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Genetic Variants Associated With Anxiety and Stress-Related Disorders

(2019) Sandra M. Meier et al.   JAMA Psychiatry

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

(2019) Henry R. Kranzler et al.   Nature Communications

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

(2019) Andrew D. Grotzinger et al.   Nature Human Behaviour

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

A major role for common genetic variation in anxiety disorders

(2019) Kirstin L. Purves et al.   MOLECULAR PSYCHIATRY

A resource-efficient tool for mixed model association analysis of large-scale data

(2019) Longda Jiang et al.   NATURE GENETICS

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

(2019) Bingxin Zhao et al.   NATURE GENETICS

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

(2019) Phil H. Lee et al.   CELL

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive

(2018) Sanghee Yun et al.   NATURE MEDICINE

The impact of parental mental illness across the full diagnostic spectrum on externalising and internalising vulnerabilities in young offspring

(2018) Kimberlie Dean et al.   PSYCHOLOGICAL MEDICINE

Analysis of shared heritability in common disorders of the brain

(2018) et al.   SCIENCE

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

(2018) David M. Howard et al.   Nature Communications

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

(2018) Raymond K. Walters et al.   NATURE NEUROSCIENCE

A polygenic p factor for major psychiatric disorders

(2018) Saskia Selzam et al.   Translational Psychiatry

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

(2017) Paul D Arnold et al.   MOLECULAR PSYCHIATRY

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study

(2017) New Fei Ho et al.   NEUROPSYCHOPHARMACOLOGY

Generalized Network Psychometrics: Combining Network and Latent Variable Models

(2017) Sacha Epskamp et al.   PSYCHOMETRIKA

A network theory of mental disorders

(2017) Denny Borsboom   World Psychiatry

GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies

(2017) Jeroen C. de Jonge et al.   Frontiers in Psychiatry

Meta-analysis of genome-wide association studies of anxiety disorders

(2016) T Otowa et al.   MOLECULAR PSYCHIATRY

Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders

(2016) D. W. Volk et al.   PSYCHOLOGICAL MEDICINE

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

(2015) Wei Li et al.   AMERICAN JOURNAL OF PSYCHIATRY

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population

(2015) E Pettersson et al.   MOLECULAR PSYCHIATRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Links between Circadian Rhythms and Psychiatric Disease

(2014) Ilia N. Karatsoreos   Frontiers in Behavioral Neuroscience

Linking the SWI/SNF complex to prostate cancer

(2013) Ryan S Lee et al.   NATURE GENETICS

Parent psychopathology and offspring mental disorders: Results from the WHO World Mental Health Surveys

(2012) Katie A. McLaughlin et al.   BRITISH JOURNAL OF PSYCHIATRY

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hippocampal Interneurons in Bipolar Disorder

(2010) Christine Konradi et al.   ARCHIVES OF GENERAL PSYCHIATRY

Antidepressants increase neural progenitor cells in the human hippocampus

(2009) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY